PKA and Epac1 Reduce Nek7 to Block the NLRP3 Inflammasome Proteins in the Retinal Vasculature

PKA and Epac1 regulated Nek7/NLRP3 signaling proteins. The schematic depicts the signaling pathway of PKA and Epac1 inhibition of Nek7 and NLRP3 signaling proteins to reduce retinal inflammation.
PKA and Epac1 Reduce Nek7 to Block the NLRP3 Inflammasome Proteins in the Retinal Vasculature
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Publication

PKA and Epac1 Reduce Nek7 to Block the NLRP3 Inflammasome Proteins in the Retinal Vasculature. (2022) Li Liu, et al. Invest Ophthalmol Vis Sci. 2022 Jan;63(1):14. Figure: F9.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates Nek7 NEK7 ncbigene_symbol NEK7 140609
Homo sapiens Primates PKA PKA famplex_relations PRKAR1A 5573
Homo sapiens Primates PKA PKA famplex_relations PRKAR1B 5575
Homo sapiens Primates PKA PKA famplex_relations PRKAR2A 5576
Homo sapiens Primates PKA PKA famplex_relations PRKAR2B 5577
Homo sapiens Primates PKA PKA famplex_relations PRKACA 5566
Homo sapiens Primates PKA PKA famplex_relations PRKACB 5567
Homo sapiens Primates PKA PKA famplex_relations PRKACG 5568
Homo sapiens Primates NLRP3 NLRP3 ncbigene_symbol NLRP3 114548
Homo sapiens Primates Caspase CASPASE famplex_relations CASP1 834
Homo sapiens Primates Caspase CASPASE famplex_relations CASP2 835
Homo sapiens Primates Caspase CASPASE famplex_relations CASP4 837
Homo sapiens Primates Caspase CASPASE famplex_relations CASP5 838
Homo sapiens Primates Caspase CASPASE famplex_relations CASP6 839
Homo sapiens Primates Caspase CASPASE famplex_relations CASP8 841
Homo sapiens Primates Caspase CASPASE famplex_relations CASP9 842
Homo sapiens Primates Caspase CASPASE famplex_relations CASP10 843
Homo sapiens Primates Caspase CASPASE famplex_relations CASP12 100506742
Homo sapiens Primates Caspase CASPASE famplex_relations CASP14 23581
Homo sapiens Primates Caspase CASPASE famplex_relations CASP3 836
Homo sapiens Primates Caspase CASPASE famplex_relations CASP7 840
Homo sapiens Primates IL-1b IL1B ncbigene_symbol IL1B 3553
Danio rerio Vertebrates Nek7 NEK7 ncbigene_symbol nek7 445223
Danio rerio Vertebrates NLRP3 NLRP3 ncbigene_symbol nlrp3 567964
Danio rerio Vertebrates IL-1b IL1B ncbigene_symbol il1b 405770

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID
Diabetic Retinopathy NA mesh:D003920