The gamma secretase (Gamma-secretase) complex: It is comprised of presenilin enhancer (PEN-2), anterior pharynx-defective 1 (APH1) and nicastrin

(a) The gamma secretase (γ-secretase) complex: It is comprised of presenilin enhancer (PEN-2), anterior pharynx-defective 1 (APH1) and nicastrin. Presenilins (PS1/PS2) are the catalytic components. (b) The five step canonical Notch pathway: (1) ADAM 10/17-mediated cleavage frees the Notch extracellular domain (NECD); (2) the receptor-NECD complex is endocytosed by epsin-mediated endocytosis; this initiates the Notch cascade; (3) γ-secretase mediated cleavage releases the transcriptionally active nuclear bound Notch intracellular domain (NICD); (4) NICD enters into the nucleus; and finally (5), NICD forms a complex with the DNA binding protein RBPj and a member of the mastermind-like (MAML) family of transcriptional co-activators to facilitate the transcription of Notch target genes. (c) Numerous genes are regulated by the Notch pathway that could play a role in epithelial–mesenchymal transitions (EMTs). CSL, CBF1, Suppressor of Hairless, Lag-1 transcription factor.
The gamma secretase (Gamma-secretase) complex: It is comprised of presenilin enhancer (PEN-2), anterior pharynx-defective 1 (APH1) and nicastrin
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Publication

A “NOTCH” Deeper into the Epithelial-To-Mesenchymal Transition (EMT) Program in Breast Cancer. (2019) Rohan Kar, et al. Genes (Basel). 2019 Dec;10(12):961. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Mus musculus Rodents PEN-2 PEN-2 ncbigene_synonym Psenen 66340
Mus musculus Rodents PS1/PS2 PS2 ncbigene_synonym Pdcd6 18570
Mus musculus Rodents PS1/PS2 PS2 ncbigene_synonym Psen2 19165
Mus musculus Rodents PS1/PS2 PS2 ncbigene_synonym Tff1 21784
Mus musculus Rodents PS1/PS2 PS1 ncbigene_synonym Psen1 19164
Mus musculus Rodents ADAM10 ADAM10 ncbigene_symbol Adam10 11487
Mus musculus Rodents ADAM10/17 ADAM17 ncbigene_symbol Adam17 11491
Mus musculus Rodents HES1 HES1 ncbigene_symbol Hes1 15205
Mus musculus Rodents HES1 HES1 ncbigene_synonym Hesx1 15209
Mus musculus Rodents HES1&HEY1 HEY1 ncbigene_symbol Hey1 15213
Mus musculus Rodents CSL CSL ncbigene_symbol Csl 71832
Mus musculus Rodents CSL CSL ncbigene_synonym Smpx 66106
Mus musculus Rodents Slug SLUG ncbigene_synonym Snai2 20583
Mus musculus Rodents Snail SNAIL ncbigene_synonym Snai1 20613
Mus musculus Rodents NF-KB NF-KB ncbigene_synonym Nfkb1 18033
Mus musculus Rodents E-cadherin CDH1 ncbigene_symbol Cdh1 12550
Mus musculus Rodents E-cadherin CDH1 ncbigene_synonym Fzr1 56371
Gallus gallus Vertebrates PS1/PS2 PS2 ncbigene_synonym PSEN2 374188
Gallus gallus Vertebrates PS1/PS2 PS1 ncbigene_synonym PSEN1 373977
Gallus gallus Vertebrates ADAM10 ADAM10 ncbigene_symbol ADAM10 374113
Gallus gallus Vertebrates ADAM10/17 ADAM17 ncbigene_symbol ADAM17 421931
Gallus gallus Vertebrates HES1 HES1 ncbigene_symbol HES1 769039
Gallus gallus Vertebrates HES1 HES1 ncbigene_synonym HES4 395128
Gallus gallus Vertebrates HES1&HEY1 HEY1 ncbigene_symbol HEY1 428365
Gallus gallus Vertebrates Snail SNAI1 ncbigene_symbol SNAI1 396047
Gallus gallus Vertebrates E-cadherin CDH1 ncbigene_symbol CDH1 415860
Homo sapiens Primates PEN-2 PEN-2 ncbigene_synonym PSENEN 55851
Homo sapiens Primates (APH1) APH1 ncbigene_synonym APH1A 51107
Homo sapiens Primates PS1/PS2 PS2 ncbigene_synonym PSEN2 5664
Homo sapiens Primates PS1/PS2 PS2 ncbigene_synonym TFF1 7031
Homo sapiens Primates PS1/PS2 PS2 ncbigene_synonym TAS2R64P 338412
Homo sapiens Primates PS1/PS2 PS1 ncbigene_synonym PSEN1 5663
Homo sapiens Primates PS1/PS2 PS1 ncbigene_synonym TAS2R62P 338399
Homo sapiens Primates Delta→ DELTA ncbigene_synonym PSMB6 5694
Homo sapiens Primates Delta→ DELTA ncbigene_synonym YY1 7528
Homo sapiens Primates Delta→ DELTA ncbigene_synonym DLL1 28514
Homo sapiens Primates +Serrate SERRATE ncbigene_synonym SRRT 51593
Homo sapiens Primates ADAM10 ADAM10 ncbigene_symbol ADAM10 102
Homo sapiens Primates ADAM10/17 ADAM17 ncbigene_symbol ADAM17 6868
Homo sapiens Primates Notch NOTCH famplex_relations NOTCH1 4851
Homo sapiens Primates Notch NOTCH famplex_relations NOTCH2 4853
Homo sapiens Primates Notch NOTCH famplex_relations NOTCH3 4854
Homo sapiens Primates Notch NOTCH famplex_relations NOTCH4 4855
Homo sapiens Primates HES1 HES1 ncbigene_symbol HES1 3280
Homo sapiens Primates HES1 HES1 ncbigene_synonym GATD3 8209
Homo sapiens Primates HES1&HEY1 HEY1 ncbigene_symbol HEY1 23462
Homo sapiens Primates CSL CSL ncbigene_synonym CSHL1 1444
Homo sapiens Primates CSL CSL ncbigene_synonym RBPJ 3516
Homo sapiens Primates CSL CSL ncbigene_synonym SMPX 23676
Homo sapiens Primates Slug SLUG ncbigene_synonym SNAI2 6591
Homo sapiens Primates Snail SNAIL ncbigene_synonym SNAI1 6615
Homo sapiens Primates NF-KB NF-KB ncbigene_synonym NFKB1 4790
Homo sapiens Primates E-cadherin CDH1 ncbigene_symbol CDH1 999
Homo sapiens Primates E-cadherin CDH1 ncbigene_synonym FZR1 51343
Arabidopsis thaliana Plants and Fungi PEN-2 PEN2 ncbigene_symbol PEN2 819056
Arabidopsis thaliana Plants and Fungi PEN-2 PEN2 ncbigene_symbol PEN2 821476
Arabidopsis thaliana Plants and Fungi PEN-2 PEN2 ncbigene_synonym BARS1 827203
Arabidopsis thaliana Plants and Fungi PS1/PS2 PS2 ncbigene_symbol PS2 817540
Arabidopsis thaliana Plants and Fungi PS1/PS2 PS2 ncbigene_symbol PS2 843632
Arabidopsis thaliana Plants and Fungi PS1/PS2 PS1 ncbigene_symbol PS1 837391
Arabidopsis thaliana Plants and Fungi PS1/PS2 PS1 ncbigene_symbol PS1 840337
Arabidopsis thaliana Plants and Fungi +Serrate SERRATE ncbigene_synonym SE 817252
Arabidopsis thaliana Plants and Fungi MAML MAML ncbigene_synonym IMS2 832366

Chemical mentions

Word Match MeSH Name ChEBI
PEN-2 NA mesh:C035086
Serrate NA mesh:C066820

Disease mentions

Word Match MeSH Name DOID