Polyunsaturated fatty acid (PUFA) metabolic pathway
Polyunsaturated fatty acid (PUFA) metabolic pathway. Animals are unable to endogenously synthesise linoleic (LA) or α-linolenic acid (LNA) and therefore these essential fatty acids must be consumed from dietary sources. Endogenous desaturases and elongases are responsible for conversion of LA and LNA to the key metabolites: arachidonic acid (AA), docosapentaenoic acid (DPA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Desaturase enzymes are the same for both omega-3 and omega-6 pathways, and therefore DHA production may be limited when the LA to LNA ratio of the diet is high.
Publication
Review on docosahexaenoic acid in poultry and swine nutrition: Consequence of enriched animal products on performance and health characteristics. (2019) Sophie A. Lee, et al. Anim Nutr. 2019 Mar;5(1):11-21. Figure: F1.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Drosophila melanogaster | Invertebrates | (LA) | LA | ncbigene_symbol | La | 35305 |
| Drosophila melanogaster | Invertebrates | (AA) | AA | ncbigene_symbol | aa | 44792 |
| Drosophila melanogaster | Invertebrates | (EPA) | EPA | ncbigene_synonym | Pka-R2 | 36041 |
| Drosophila melanogaster | Invertebrates | (DPA) | DPA | ncbigene_symbol | dpa | 35679 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| Omega-6 PUFA | Fatty Acids, Omega-3 | mesh:D015525 | omega-3 fatty acid | chebi:25681 |
| Omega-3 PUFA | Fatty Acids, Omega-3 | mesh:D015525 | omega-3 fatty acid | chebi:25681 |
| Linoleic acid | NA | mesh:D008041 | ||
| linolenic acid | Linolenic Acids | mesh:D008042 | linolenic acid | chebi:25048 |
| Arachidonic acid | NA | mesh:D001095 | ||
| Eicosapentaenoic | Eicosapentaenoic Acid | mesh:D015118 | all-cis-5,8,11,14,17-icosapentaenoic acid | chebi:28364 |
| EPA | NA | mesh:C062422 | ||
| Docosapentaenoic acid | NA | mesh:C026219 | ||
| DPA | NA | mesh:C502590 | ||
| Docosahexaenoic acid | Docosahexaenoic Acids | mesh:D004281 | docosahexaenoic acid | chebi:36005 |
| DHA | NA | mesh:C111716 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
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