Signaling pathways interconnecting V-ATPase and glycolysis

Signaling pathways interconnecting V-ATPase and glycolysis. V-ATPase assembly, activity, and cellular membrane distribution reflect glucose and energy levels within the cell. PKA, AMPK, and PI3K are the common glucose-sensitive signaling pathways that regulate assembly (i, ii) and trafficking (iii) of V-ATPase in fungi and mammals. Reciprocal regulation of glycolysis by V-ATPase (iv) appears to be unique to mammals and is modulated by alterations in HIF-1. V-ATPase is also crucial for metabolic reprogramming (v); this entails assembly of V-ATPase, aldolase, mTORC1, and AMPK into evolutionarily-conserved super-complexes.
Signaling pathways interconnecting V-ATPase and glycolysis
Download JPG
View figure at PMC Read paper at PMC Open at NDEx
PMC
NDEx

Publication

Reciprocal Regulation of V-ATPase and Glycolytic Pathway Elements in Health and Disease. (2019) Summer R. Hayek, et al. Front Physiol. 2019;10:127. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates Ras/PKA RAS famplex_relations KRAS 3845
Homo sapiens Primates Ras/PKA RAS famplex_relations HRAS 3265
Homo sapiens Primates Ras/PKA RAS famplex_relations NRAS 4893
Homo sapiens Primates Ras/PKA PKA famplex_relations PRKAR1A 5573
Homo sapiens Primates Ras/PKA PKA famplex_relations PRKAR1B 5575
Homo sapiens Primates Ras/PKA PKA famplex_relations PRKAR2A 5576
Homo sapiens Primates Ras/PKA PKA famplex_relations PRKAR2B 5577
Homo sapiens Primates Ras/PKA PKA famplex_relations PRKACA 5566
Homo sapiens Primates Ras/PKA PKA famplex_relations PRKACB 5567
Homo sapiens Primates Ras/PKA PKA famplex_relations PRKACG 5568
Homo sapiens Primates HIF-1a HIF-1A ncbigene_synonym HIF1A 3091
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAA1 5562
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAA2 5563
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAB1 5564
Homo sapiens Primates AMPK AMPK famplex_relations PRKAB2 5565
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG1 5571
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG2 51422
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG3 53632
Homo sapiens Primates PFK-1 PFK-1 ncbigene_synonym PFKM 5213
Homo sapiens Primates Vps34 VPS34 ncbigene_synonym PIK3C3 5289
Homo sapiens Primates V-ATPase ATPASE ncbigene_synonym DNAH8 1769
Homo sapiens Primates TORC1 TORC1 ncbigene_synonym CRTC1 23373
Homo sapiens Primates MTORC1 MTORC1 famplex_relations MTOR 2475
Homo sapiens Primates MTORC1 MTORC1 famplex_relations RPTOR 57521
Saccharomyces cerevisiae S288C Plants and Fungi PFK-1 PFK1 ncbigene_symbol PFK1 853155
Saccharomyces cerevisiae S288C Plants and Fungi Vps34 VPS34 ncbigene_symbol VPS34 850941
Saccharomyces cerevisiae S288C Plants and Fungi SNF1 SNF1 ncbigene_symbol SNF1 852088

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID