Response to immunotherapy in pancreatic ductal adenocarcinoma (PDAC) relies on destroying cancer cells as well as on breaking the stromal barrier and flaring up immune function

The response to immunotherapy in pancreatic ductal adenocarcinoma (PDAC) relies on destroying cancer cells as well as on breaking the stromal barrier and flaring up immune function. Immunotherapy targeting the PD-1/PD-L1 pathway and TME has disrupted the traditional method of cancer treatment and countered the immune-related adverse events in patients. In addition to direct cytotoxicity on cancer cells, it is important to dissect the immunosuppressive microenvironment with various cytokines and immune cells. Furthermore, recognition of mechanisms modulating the PD-1/PD-L1 pathway and TME will identify more potential therapeutic targets in the future.
Response to immunotherapy in pancreatic ductal adenocarcinoma (PDAC) relies on destroying cancer cells as well as on breaking the stromal barrier and flaring up immune function
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Publication

From Friend to Enemy: Dissecting the Functional Alteration of Immunoregulatory Components during Pancreatic Tumorigenesis. (2018) Hui-Ching Wang, et al. Int J Mol Sci. 2018 Nov;19(11):3584. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Mus musculus Rodents Hot HOT ncbigene_synonym Adhfe1 76187
Mus musculus Rodents PSCS PSCS ncbigene_symbol Pscs 107810
Mus musculus Rodents DCs DCS ncbigene_synonym Mthfd1 108156
Mus musculus Rodents GLI1, GLI1 ncbigene_symbol Gli1 14632
Mus musculus Rodents SHH,GLI1,VEGF SHH ncbigene_symbol Shh 20423
Mus musculus Rodents SHH,GLI1,VEGF VEGF ncbigene_synonym Vegfa 22339
Mus musculus Rodents 2.Chemokines(ex.TGF-B,ILs,CSF,CCRSand CSF ncbigene_synonym Csf2 12981
Mus musculus Rodents TGF-B, TGFB ncbigene_synonym Tgfb1 21803
Mus musculus Rodents TGF-B, TGFB ncbigene_synonym Ltbp1 268977
Mus musculus Rodents ARG-1, ARG-1 ncbigene_synonym Arg1 11846
Mus musculus Rodents EMT EMT ncbigene_synonym Itk 16428
Mus musculus Rodents EMT EMT ncbigene_synonym Slc22a3 20519
Mus musculus Rodents CTLA-4 CTLA-4 ncbigene_synonym Ctla4 12477
Mus musculus Rodents PD-L1 PDL1 ncbigene_synonym Cd274 60533
Mus musculus Rodents CXCR4 CXCR4 ncbigene_symbol Cxcr4 12767
Homo sapiens Primates Hot HOT ncbigene_synonym ADHFE1 137872
Homo sapiens Primates GLI1, GLI1 ncbigene_symbol GLI1 2735
Homo sapiens Primates SHH,GLI1,VEGF SHH ncbigene_symbol SHH 6469
Homo sapiens Primates SHH,GLI1,VEGF VEGF ncbigene_synonym VEGFA 7422
Homo sapiens Primates SHH,GLI1,VEGF VEGF famplex_relations VEGFB 7423
Homo sapiens Primates SHH,GLI1,VEGF VEGF famplex_relations VEGFC 7424
Homo sapiens Primates SHH,GLI1,VEGF VEGF famplex_relations VEGFD 2277
Homo sapiens Primates SHH,GLI1,VEGF VEGF famplex_relations PGF 5228
Homo sapiens Primates Chemokines CHEMOKINE famplex_relations CXCL10 3627
Homo sapiens Primates Chemokines CHEMOKINE famplex_relations CXCL11 6373
Homo sapiens Primates Chemokines CHEMOKINE famplex_relations CXCL12 6387
Homo sapiens Primates Chemokines CHEMOKINE famplex_relations CXCL13 10563
Homo sapiens Primates Chemokines CHEMOKINE famplex_relations CXCL14 9547
Homo sapiens Primates Chemokines CHEMOKINE famplex_relations CXCL9 4283
Homo sapiens Primates Chemokines CHEMOKINE famplex_relations PF4 5196
Homo sapiens Primates Chemokines CHEMOKINE famplex_relations CXCL1 2919
Homo sapiens Primates Chemokines CHEMOKINE famplex_relations CXCL2 2920
Homo sapiens Primates Chemokines CHEMOKINE famplex_relations CXCL3 2921
Homo sapiens Primates Chemokines CHEMOKINE famplex_relations CXCL5 6374
Homo sapiens Primates Chemokines CHEMOKINE famplex_relations CXCL6 6372
Homo sapiens Primates Chemokines CHEMOKINE famplex_relations CXCL8 3576
Homo sapiens Primates Chemokines CHEMOKINE famplex_relations PPBP 5473
Homo sapiens Primates 2.Chemokines(ex.TGF-B,ILs,CSF,CCRSand CSF ncbigene_synonym CSF2 1437
Homo sapiens Primates 2.Chemokines(ex.TGF-B,ILs,CSF,CCRSand CSF ncbigene_synonym LAMC2 3918
Homo sapiens Primates TGF-B, TGFB ncbigene_synonym TGFB1 7040
Homo sapiens Primates TGF-B, TGFB famplex_relations TGFB2 7042
Homo sapiens Primates TGF-B, TGFB famplex_relations TGFB3 7043
Homo sapiens Primates ARG-1, ARG1 ncbigene_symbol ARG1 383
Homo sapiens Primates ARG-1, ARG1 ncbigene_synonym TINAGL1 64129
Homo sapiens Primates EMT EMT ncbigene_synonym ITK 3702
Homo sapiens Primates EMT EMT ncbigene_synonym SLC22A3 6581
Homo sapiens Primates CTLA-4 CTLA-4 ncbigene_synonym CTLA4 1493
Homo sapiens Primates PD-L1 PD-L1 ncbigene_synonym CD274 29126
Homo sapiens Primates CXCR4 CXCR4 ncbigene_symbol CXCR4 7852
Drosophila melanogaster Invertebrates Cold COLD ncbigene_symbol cold 33237
Drosophila melanogaster Invertebrates SHH,GLI1,VEGF VEGF ncbigene_synonym Pvf1 32876
Drosophila melanogaster Invertebrates SHH,GLI1,VEGF VEGF ncbigene_synonym Pvf2 33994
Drosophila melanogaster Invertebrates SHH,GLI1,VEGF VEGF ncbigene_synonym Pvf3 33995
Drosophila melanogaster Invertebrates SHH,GLI1,VEGF VEGF ncbigene_synonym Pvr 34127
Drosophila melanogaster Invertebrates and AND ncbigene_synonym CkIIbeta 32132
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Andorra 32798
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Anp 43595
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Acam 44913
Drosophila melanogaster Invertebrates TGF-B, TGF-B ncbigene_synonym dpp 33432
Drosophila melanogaster Invertebrates TGF-B, TGF-B ncbigene_synonym gbb 37778
Drosophila melanogaster Invertebrates TGF-B, TGF-B ncbigene_synonym put 41772
Drosophila melanogaster Invertebrates TGF-B, TGF-B ncbigene_synonym mav 43804
Drosophila melanogaster Invertebrates cycle CYCLE ncbigene_synonym CycE 34924
Drosophila melanogaster Invertebrates cycle CYCLE ncbigene_synonym cyc 40162

Chemical mentions

Word Match MeSH Name ChEBI
ATRA Tretinoin mesh:D014212 all-trans-retinoic acid chebi:15367
pexidartinib NA
lenalidomide NA mesh:C467567
acalabrutinib NA
paricalcitol paricalcitol mesh:C084656 paricalcitol chebi:7931
paclitaxel Paclitaxel mesh:D017239 paclitaxel chebi:45863
cyclophosphamide Cyclophosphamide mesh:D003520 cyclophosphamide chebi:4027
cyclophosphamide Cyclophosphamide mesh:D003520 cyclophosphamide hydrate chebi:4026
ARG NA mesh:C545206
gemcitabine gemcitabine mesh:C056507 gemcitabine chebi:175901

Disease mentions

Word Match MeSH Name DOID