Scheme of the phenylpropanoid pathway
Scheme of the phenylpropanoid pathway. Direct interactions between particular biosynthetic enzymes, demonstrated by means of co-immunoprecipitation, BiFC or FRET, are illustrated by red arrows. Discontinuous lines indicate that certain steps along the pathway are not included in the figure. The enzymes are: PAL, phenylalanine ammonia-lyase; C4H, cinnamic acid 4-hydroxylase; 4CL, 4-coumarate:CoA ligase; CCR, cinnamoyl CoA reductase; CAD, cinnamoyl alcohol dehydrogenase; PER/LAC, peroxidase/laccase; HCT, shikimate hydroxycinnamoyl transferase; C3H/C4H, 4-coumarylshikimate 3-hydroxylase/cinnamate 4-hydroxylase; CHS, chalcone synthase; CHR, chalcone reductase; CHI, chalcone isomerase; IFS, isoflavone synthase; IOMT, isoflavone O-methyltransferase; HID, hydroxyisoflavanone dehydratase; F3H, flavanone 3 hydroxylase; DFR, dihydroflavonol 4-reductase; FNSII, flavanone synthase II; FLS, flavonol synthase.
Publication
The Phenylpropanoid Case – It Is Transport That Matters. (2018) Wanda Biała, et al. Front Plant Sci. 2018;9:1610. Figure: F1.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Vitis vinifera | Plants and Fungi | 4CL | 4CL | ncbigene_symbol | 4CL | 100245991 |
| Vitis vinifera | Plants and Fungi | CHS | CHS | ncbigene_symbol | CHS | 100232843 |
| Vitis vinifera | Plants and Fungi | CHS | CHS | ncbigene_symbol | CHS | 100263443 |
| Vitis vinifera | Plants and Fungi | CHI | CHI | ncbigene_symbol | CHI | 100233078 |
| Vitis vinifera | Plants and Fungi | F3H | F3H | ncbigene_symbol | F3H | 100233079 |
| Vitis vinifera | Plants and Fungi | DFR | DFR | ncbigene_symbol | DFR | 100233141 |
| Arabidopsis thaliana | Plants and Fungi | C4H | C4H | ncbigene_symbol | C4H | 817599 |
| Arabidopsis thaliana | Plants and Fungi | CHS | CHS | ncbigene_synonym | TT4 | 831241 |
| Arabidopsis thaliana | Plants and Fungi | HCT | HCT | ncbigene_symbol | HCT | 834951 |
| Arabidopsis thaliana | Plants and Fungi | CHI | CHI | ncbigene_symbol | CHI | 818959 |
| Arabidopsis thaliana | Plants and Fungi | CHI | CHI | ncbigene_synonym | TT5 | 824678 |
| Arabidopsis thaliana | Plants and Fungi | CAD| | CAD | ncbigene_synonym | ATCAD4 | 821479 |
| Arabidopsis thaliana | Plants and Fungi | F3H | F3H | ncbigene_symbol | F3H | 824287 |
| Arabidopsis thaliana | Plants and Fungi | FLS, | FLS | ncbigene_synonym | FLS1 | 830765 |
| Arabidopsis thaliana | Plants and Fungi | FLS, | FLS | ncbigene_synonym | FLS3 | 836478 |
| Arabidopsis thaliana | Plants and Fungi | DFR | DFR | ncbigene_symbol | DFR | 834291 |
| Glycine max | Plants and Fungi | C4H | C4H | ncbigene_symbol | C4H | 100499623 |
| Glycine max | Plants and Fungi | 4CL | 4CL | ncbigene_symbol | 4CL | 100797843 |
| Glycine max | Plants and Fungi | 4CL | 4CL | ncbigene_synonym | 4CL4 | 547930 |
| Glycine max | Plants and Fungi | CHS | CHS | ncbigene_synonym | CHS10 | 100788048 |
| Glycine max | Plants and Fungi | CHS | CHS | ncbigene_synonym | CHS3 | 100791524 |
| Glycine max | Plants and Fungi | CHI | CHI | ncbigene_synonym | CHI1A | 547602 |
| Glycine max | Plants and Fungi | CHI | CHI | ncbigene_synonym | CHI2-A | 732546 |
| Glycine max | Plants and Fungi | CCR | CCR | ncbigene_symbol | CCR | 100796771 |
| Glycine max | Plants and Fungi | IFS | IFS | ncbigene_synonym | IFS1 | 100037450 |
| Glycine max | Plants and Fungi | F3H | F3H | ncbigene_symbol | F3H | 732548 |
| Homo sapiens | Primates | PAL | PAL | ncbigene_synonym | PAM | 5066 |
| Homo sapiens | Primates | PAL | PAL | ncbigene_synonym | LRIT1 | 26103 |
| Homo sapiens | Primates | PAL | PAL | ncbigene_synonym | SHCBP1 | 79801 |
| Homo sapiens | Primates | CHS | CHS | ncbigene_synonym | LYST | 1130 |
| Homo sapiens | Primates | CAD| | CAD | ncbigene_symbol | CAD | 790 |
| Homo sapiens | Primates | CAD| | CAD | ncbigene_synonym | DFFB | 1677 |
| Homo sapiens | Primates | CAD| | CAD | ncbigene_synonym | ACOD1 | 730249 |
| Homo sapiens | Primates | LAC| | LAC | ncbigene_synonym | LCT | 3938 |
| Homo sapiens | Primates | PER/LAC| | PER | ncbigene_synonym | PER1 | 5187 |
| Homo sapiens | Primates | HID | HID | ncbigene_synonym | GJB2 | 2706 |
| Zea mays | Plants and Fungi | 4CL | 4CL | ncbigene_synonym | LOC542166 | 542166 |
| Zea mays | Plants and Fungi | CCR | CCR | ncbigene_synonym | LOC542463 | 542463 |
| Zea mays | Plants and Fungi | CAD| | CAD | ncbigene_synonym | LOC542663 | 542663 |
| Zea mays | Plants and Fungi | F3H | F3H | ncbigene_synonym | LOC542712 | 542712 |
| Zea mays | Plants and Fungi | DFR | DFR | ncbigene_synonym | A1 | 100286107 |
| Populus trichocarpa | Plants and Fungi | PAL | PAL | ncbigene_synonym | LOC18100180 | 18100180 |
| Populus trichocarpa | Plants and Fungi | CHS | CHS | ncbigene_synonym | LOC7466313 | 7466313 |
| Populus trichocarpa | Plants and Fungi | CHI | CHI | ncbigene_synonym | LOC7462014 | 7462014 |
| Populus trichocarpa | Plants and Fungi | CCR | CCR | ncbigene_synonym | LOC7493223 | 7493223 |
| Populus trichocarpa | Plants and Fungi | CAD| | CAD | ncbigene_synonym | LOC7490064 | 7490064 |
| Drosophila melanogaster | Invertebrates | PAL | PAL | ncbigene_symbol | pal | 45912 |
| Drosophila melanogaster | Invertebrates | PAL | PAL | ncbigene_synonym | Pal2 | 37746 |
| Drosophila melanogaster | Invertebrates | HD | HD | ncbigene_symbol | hd | 40642 |
| Drosophila melanogaster | Invertebrates | CHI | CHI | ncbigene_symbol | Chi | 37837 |
| Drosophila melanogaster | Invertebrates | CHI | CHI | ncbigene_synonym | chic | 33834 |
| Drosophila melanogaster | Invertebrates | CHR | CHR | ncbigene_symbol | chr | 250498 |
| Drosophila melanogaster | Invertebrates | CHR | CHR | ncbigene_synonym | Chro | 40508 |
| Drosophila melanogaster | Invertebrates | CHR | CHR | ncbigene_synonym | RabX1 | 44172 |
| Drosophila melanogaster | Invertebrates | CCR | CCR | ncbigene_synonym | Cpr | 33883 |
| Drosophila melanogaster | Invertebrates | CAD| | CAD | ncbigene_symbol | cad | 35341 |
| Drosophila melanogaster | Invertebrates | CAD| | CAD | ncbigene_synonym | NA | 32640 |
| Drosophila melanogaster | Invertebrates | CAD| | CAD | ncbigene_synonym | Drep4 | 34734 |
| Drosophila melanogaster | Invertebrates | CAD| | CAD | ncbigene_synonym | Ca-alpha1D | 34950 |
| Drosophila melanogaster | Invertebrates | CAD| | CAD | ncbigene_synonym | shg | 37386 |
| Drosophila melanogaster | Invertebrates | DFR | DFR | ncbigene_synonym | ppk | 34843 |
| Drosophila melanogaster | Invertebrates | DFR | DFR | ncbigene_synonym | vvl | 38752 |
| Drosophila melanogaster | Invertebrates | LAC| | LAC | ncbigene_symbol | Lac | 36363 |
| Drosophila melanogaster | Invertebrates | LAC| | LAC | ncbigene_synonym | lacquered | 44521 |
| Drosophila melanogaster | Invertebrates | PER/LAC| | PER | ncbigene_symbol | per | 31251 |
| Drosophila melanogaster | Invertebrates | HID | HID | ncbigene_symbol | hid | 40009 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| trans-cinnamic acid | NA | mesh:C426667 | ||
| L-phenylalanine | Leu-Phe | mesh:C119108 | leucyl-phenylalanine | chebi:73585 |
| 4-coumarate | NA | mesh:C573280 | ||
| p-coumarylo-CoA | NA | mesh:C065987 | ||
| 3 malonylo-CoA -p-coumarylo-CoA | NA | mesh:C065987 | ||
| 3 malonylo-CoA CHS | NA | mesh:C544694 | ||
| CH scopoletin | Scopoletin | mesh:D012603 | scopoletin | chebi:17488 |
| naringenin chalcone | NA | mesh:C027329 | ||
| CHI | NA | mesh:C084533 | ||
| naringenin | NA | mesh:C005273 | ||
| Ip-coumaryl-shikimate | NA | mesh:C453473 | ||
| isoliquiritigenin | NA | mesh:C040920 | ||
| apigenin | Apigenin | mesh:D047310 | apigenin | chebi:18388 |
| p-coumaryl-aldehyde | NA | mesh:C495469 | ||
| liquiritigenin | liquiritigenin | mesh:C083152 | liquiritigenin | chebi:28777 |
| genistein | NA | mesh:D019833 | ||
| caffeyol | NA | |||
| trihydroxyisoflavanone | 2,4',7-trihydroxyisoflavanone | mesh:C420227 | 2,7,4'-trihydroxyisoflavanone | chebi:52047 |
| 2,7-dihydroxy 4methoxy | NA | mesh:C063423 | ||
| isoflavanone | NA | mesh:C065753 | ||
| coumaryl alcohol | NA | mesh:C495469 | ||
| flavonols | Flavonols | mesh:D044948 | flavonols | chebi:28802 |
| dihydroflavonols | NA | mesh:C436146 | ||
| caffeyol-CoA | NA | mesh:C065987 | ||
| H monolignol | NA | mesh:C434470 | ||
| leucoanthocyanidins | Anthocyanins | mesh:D000872 | anthocyanin | chebi:38697 |
| coniferyl alcohol sinapyl alcohol | Ethanol | mesh:D000431 | ethanol | chebi:16236 |
| formononetin | NA | mesh:C007768 | ||
| malvidin 3-0-glucoside cyanidin 3-0-glucoside | malvidin 3-O-beta-D-glucoside | mesh:C458419 | malvidin-3-glucoside | chebi:31799 |
| monolignol | NA | mesh:C434470 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|---|---|---|---|
| CHS | NA | mesh:D002609 | ||
| CHS CHR | NA | mesh:D002609 | ||
| HID | NA | mesh:C566528 |