Probable metabolic pathway for the biosynthesis of 3-methylbutanal from l-leucine degradation by B

Probable metabolic pathway for the biosynthesis of 3-methylbutanal from l-leucine degradation by B. thermosphacta. All the genes encoding the necessary enzymes for the direct (dark line) and the indirect (gray line) pathways were present. Alcohol dehydrogenase was also present. BCAA refrers to branched-chain amino acids. *The kdcA gene is fragmented in B. thermosphacta CD 337. The underlined gene bkdAB is fragmented in BSAS1 3
Probable metabolic pathway for the biosynthesis of 3-methylbutanal from l-leucine degradation by B
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Publication

One complete and three draft genome sequences of four Brochothrix thermosphacta strains, CD 337, TAP 175, BSAS1 3 and EBP 3070. (2018) Nassima Illikoud, et al. Stand Genomic Sci. 2018;13:22. Figure: F5.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Brochothrix thermosphacta Bacteria gdha GDHA ncbigene_symbol gdhA 66537698
Brochothrix thermosphacta Bacteria plsx PLSX ncbigene_symbol plsX 66536234
Brochothrix thermosphacta Bacteria buk BUK ncbigene_symbol buk 66536671
Brochothrix thermosphacta Bacteria buk BUK ncbigene_symbol buk 66538143
Brochothrix thermosphacta Bacteria adhP ADHP ncbigene_symbol adhP 66536303
Drosophila melanogaster Invertebrates EC EC ncbigene_symbol ec 31339
Drosophila melanogaster Invertebrates E1-B: E1B ncbigene_synonym Pdhb 43437
Drosophila melanogaster Invertebrates bkd BKD ncbigene_symbol Bkd 5656852
Drosophila melanogaster Invertebrates E3: E3 ncbigene_symbol E3 5658048
Drosophila melanogaster Invertebrates PI PI ncbigene_symbol pi 5656965
Drosophila melanogaster Invertebrates ADP ADP ncbigene_symbol adp 37073
Drosophila melanogaster Invertebrates ATP ATP ncbigene_synonym ATPsynbeta 43829
Drosophila melanogaster Invertebrates ATP ATP ncbigene_synonym Atpalpha 48971
Escherichia coli str. K-12 substr. MG1655 Bacteria ilvE ILVE ncbigene_symbol ilvE 948278
Escherichia coli str. K-12 substr. MG1655 Bacteria gdha GDHA ncbigene_symbol gdhA 946802
Escherichia coli str. K-12 substr. MG1655 Bacteria plsx PLSX ncbigene_symbol plsX 946165
Escherichia coli str. K-12 substr. MG1655 Bacteria alda ALDA ncbigene_symbol aldA 945672
Escherichia coli str. K-12 substr. MG1655 Bacteria alda AIDA ncbigene_synonym alkA 947371
Escherichia coli str. K-12 substr. MG1655 Bacteria adhP ADHP ncbigene_symbol adhP 946036
Homo sapiens Primates BCAA BCAA ncbigene_synonym ARID4B 51742
Homo sapiens Primates BTCD BTCD ncbigene_synonym KIN 22944
Homo sapiens Primates E1-a: E1A ncbigene_synonym PDHA1 5160
Homo sapiens Primates E1-a: E1A ncbigene_synonym DHTKD1 55526
Homo sapiens Primates E1-B: E1B ncbigene_synonym BCKDHB 594
Homo sapiens Primates E1-B: E1B ncbigene_synonym PDHB 5162
Homo sapiens Primates E1-B: E1B ncbigene_synonym SNORA73A 6080
Homo sapiens Primates ADP ADP ncbigene_synonym WDTC1 23038
Homo sapiens Primates alda ALDA ncbigene_synonym ALDOA 226
Homo sapiens Primates alda AIDA ncbigene_symbol AIDA 64853
Homo sapiens Primates alda AIDA ncbigene_synonym ANKS1B 56899
Homo sapiens Primates ATP ATP ncbigene_synonym ATP8A2 51761

Chemical mentions

Word Match MeSH Name ChEBI
Leucine NA mesh:C038361
leucine NA mesh:C038361
Glutamate NA
Ketoisocaproate NA mesh:C013082
Isovaleryl-CoA isovaleryl-CoA mesh:C017447 isovaleryl-coenzyme A chebi:15487
NAD NAD mesh:D009243 NAD(+) chebi:15846
NADH NAD mesh:D009243 NAD(+) chebi:15846
Phosphate NA mesh:D010710
Isovaleryl isovaleryl-CoA mesh:C017447 isovaleryl-coenzyme A chebi:15487
ADP NA mesh:D000244
Alcohol Ethanol mesh:D000431 ethanol chebi:16236
Aldehyde Aldehydes mesh:D000447 aldehyde chebi:17478
Methylbutanol NA mesh:D000439
3-Methylbutanal NA mesh:C032251
Isovalerate ethyl isovalerate mesh:C475857 ethyl isovalerate chebi:31571
3-Methylbutanol NA mesh:D000439

Disease mentions

Word Match MeSH Name DOID