Therapeutic targeting of oncogenic transcription factors by natural products in eye cancer

Retinoblastoma is characterized by the lack of pRB or the overexpression of MYCN. (A) BET inhibitors target MYCN (blue). (B) Wortmannin, β-lapachone, and paclitaxel target ARF/MDM2-MDMX/p53 (pink). (C) Trichostatin and topotecan target HIF-1 (purple). (D) Celastrol and chebulagic acid target NFκB pathway (green).
Therapeutic targeting of oncogenic transcription factors by natural products in eye cancer
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Publication

Therapeutic targeting of oncogenic transcription factors by natural products in eye cancer. (2018) Michelle G Zhang, et al. Pharmacol Res. 2018 Mar;129:365-374. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates Cdk4/6 CDK6 ncbigene_symbol CDK6 1021
Homo sapiens Primates Cdk4/6 CDK4 ncbigene_symbol CDK4 1019
Homo sapiens Primates HDAC HDAC ncbigene_synonym HDAC9 9734
Homo sapiens Primates HDAC HDAC famplex_relations HDAC1 3065
Homo sapiens Primates HDAC HDAC famplex_relations HDAC2 3066
Homo sapiens Primates HDAC HDAC famplex_relations HDAC3 8841
Homo sapiens Primates HDAC HDAC famplex_relations HDAC8 55869
Homo sapiens Primates HDAC HDAC famplex_relations HDAC4 9759
Homo sapiens Primates HDAC HDAC famplex_relations HDAC5 10014
Homo sapiens Primates HDAC HDAC famplex_relations HDAC7 51564
Homo sapiens Primates HDAC HDAC famplex_relations HDAC6 10013
Homo sapiens Primates HDAC HDAC famplex_relations HDAC10 83933
Homo sapiens Primates HDAC HDAC famplex_relations SIRT1 23411
Homo sapiens Primates HDAC HDAC famplex_relations SIRT2 22933
Homo sapiens Primates HDAC HDAC famplex_relations SIRT3 23410
Homo sapiens Primates HDAC HDAC famplex_relations SIRT4 23409
Homo sapiens Primates HDAC HDAC famplex_relations SIRT5 23408
Homo sapiens Primates HDAC HDAC famplex_relations SIRT6 51548
Homo sapiens Primates HDAC HDAC famplex_relations SIRT7 51547
Homo sapiens Primates HDAC HDAC famplex_relations HDAC11 79885
Homo sapiens Primates MDM4 MDM4 ncbigene_symbol MDM4 4194
Homo sapiens Primates IKK IKK famplex_relations CHUK 1147
Homo sapiens Primates IKK IKK famplex_relations IKBKB 3551
Homo sapiens Primates IKK IKK famplex_relations IKBKG 8517
Homo sapiens Primates IKK IKK famplex_relations IKBKE 9641
Homo sapiens Primates IKK IKK famplex_relations TBK1 29110
Homo sapiens Primates PVHL PVHL ncbigene_synonym VHL 7428
Homo sapiens Primates MDM2 MDM2 ncbigene_symbol MDM2 4193
Homo sapiens Primates p53 P53 ncbigene_synonym TP53 7157
Homo sapiens Primates p53 P53 famplex_relations TP63 8626
Homo sapiens Primates p53 P53 famplex_relations TP73 7161
Homo sapiens Primates PRB PRB ncbigene_synonym RB1 5925
Homo sapiens Primates P14ARF P14ARF ncbigene_synonym CDKN2A 1029
Homo sapiens Primates HIF HIF famplex_relations HIF1A 3091
Homo sapiens Primates HIF HIF famplex_relations EPAS1 2034
Homo sapiens Primates HIF HIF famplex_relations HIF3A 64344
Homo sapiens Primates HIF HIF famplex_relations ARNT 405
Homo sapiens Primates HIF HIF famplex_relations ARNT2 9915
Homo sapiens Primates HIF HIF famplex_relations BMAL1 406
Homo sapiens Primates HIF-1 HIF-1 ncbigene_synonym SETD2 29072
Homo sapiens Primates MYCN MYCN ncbigene_symbol MYCN 4613
Homo sapiens Primates E2F E2F famplex_relations E2F1 1869
Homo sapiens Primates E2F E2F famplex_relations E2F2 1870
Homo sapiens Primates E2F E2F famplex_relations E2F3 1871
Homo sapiens Primates E2F E2F famplex_relations E2F4 1874
Homo sapiens Primates E2F E2F famplex_relations E2F5 1875
Homo sapiens Primates E2F E2F famplex_relations E2F6 1876
Homo sapiens Primates E2F E2F famplex_relations E2F7 144455
Homo sapiens Primates E2F E2F famplex_relations E2F8 79733
Homo sapiens Primates NFKB NFKB ncbigene_synonym NFKB1 4790
Homo sapiens Primates NFKB NFKB famplex_relations RELA 5970
Homo sapiens Primates NFKB NFKB famplex_relations RELB 5971
Homo sapiens Primates NFKB NFKB famplex_relations REL 5966
Homo sapiens Primates NFKB NFKB famplex_relations NFKB2 4791
Homo sapiens Primates BET BET ncbigene_synonym DNER 92737
Homo sapiens Primates PDK1 PDK1 ncbigene_symbol PDK1 5163
Homo sapiens Primates PDK1 PDK1 ncbigene_synonym PDPK1 5170
Mus musculus Rodents PI3K PI3K ncbigene_synonym Pik3r1 18708
Mus musculus Rodents Cdk4/6 CDK6 ncbigene_symbol Cdk6 12571
Mus musculus Rodents Cdk4/6 CDK4 ncbigene_symbol Cdk4 12567
Mus musculus Rodents MDM4 MDM4 ncbigene_symbol Mdm4 17248
Mus musculus Rodents PVHL PVHL ncbigene_synonym Vhl 22346
Mus musculus Rodents MDM2 MDM2 ncbigene_symbol Mdm2 17246
Mus musculus Rodents p53 P53 ncbigene_synonym Trp53 22059
Mus musculus Rodents PRB PRB ncbigene_synonym Pgr 18667
Mus musculus Rodents PRB PRB ncbigene_synonym Rb1 19645
Mus musculus Rodents IKB IKB ncbigene_synonym Nfkbib 18036
Mus musculus Rodents MYCN MYCN ncbigene_symbol Mycn 18109
Mus musculus Rodents NFKB NFKB ncbigene_synonym Nfkb1 18033
Mus musculus Rodents BET BET ncbigene_synonym Ptprj 19271
Mus musculus Rodents BET BET ncbigene_synonym Dner 227325
Mus musculus Rodents PDK1 PDK1 ncbigene_symbol Pdk1 228026
Mus musculus Rodents PDK1 PDK1 ncbigene_synonym Pdpk1 18607
Gallus gallus Vertebrates Cdk4/6 CDK6 ncbigene_symbol CDK6 420558
Gallus gallus Vertebrates MDM4 MDM4 ncbigene_symbol MDM4 419823
Gallus gallus Vertebrates MDM2 MDM2 ncbigene_symbol MDM2 395609
Gallus gallus Vertebrates MYCN MYCN ncbigene_symbol MYCN 421948
Gallus gallus Vertebrates PDK1 PDK1 ncbigene_symbol PDK1 425972
Danio rerio Vertebrates Cdk4/6 CDK6 ncbigene_symbol cdk6 100034507
Danio rerio Vertebrates Cdk4/6 CDK4 ncbigene_symbol cdk4 777730
Danio rerio Vertebrates MDM4 MDM4 ncbigene_symbol mdm4 334932
Danio rerio Vertebrates MDM2 MDM2 ncbigene_symbol mdm2 30637
Danio rerio Vertebrates p53 P53 ncbigene_synonym tp53 30590
Danio rerio Vertebrates MYCN MYCN ncbigene_symbol mycn 252851
Danio rerio Vertebrates PDK1 PDK1 ncbigene_symbol pdk1 555840

Chemical mentions

Word Match MeSH Name ChEBI
Wortmannin NA mesh:C009687
Trichostatin NA mesh:C012589
B-lapachone NA mesh:C415043
Paclitaxel Paclitaxel mesh:D017239 paclitaxel chebi:45863
Celastrol NA mesh:C050414

Disease mentions

Word Match MeSH Name DOID
Cancer NA