Overview of the IDO metabolic pathway
Overview of the IDO metabolic pathway. Approximately 95% of L-tryptophan (Trp) is catabolized into kynurenine (Kyn) through three rate-limiting enzymes: tryptophan 2,3-dioxygenase (TDO) in the liver and indoleamine 2, 3-dioxygenase 1/2 (IDO1/2) in peripheral tissues. Kyn is converted to 3-hydroxykynurenine (3-HK) by kynurenine 3-monooxygenase (KMO), to anthranilic acid (AA) by kynureninase (KYNase), or to kynurenic acid (KYNA) by kynurenine aminotransferase (KAT). Next, catalyzed by KYNase, 3-HK is converted to 3-hydroxyanthranilic acid (3-HAA), which is further converted to quinolinic acid (QA), picolinic acid, nicotinamide adenine dinucleotide (NAD+), and other molecules
Publication
Targeting the IDO1 pathway in cancer: from bench to bedside. (2018) Ming Liu, et al. J Hematol Oncol. 2018;11:100. Figure: F1.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | IDO1/2 | IDO2 | ncbigene_symbol | IDO2 | 169355 |
| Homo sapiens | Primates | IDO1/2 | IDO1 | ncbigene_symbol | IDO1 | 3620 |
| Homo sapiens | Primates | IDO1/2 | ID2 | ncbigene_symbol | ID2 | 3398 |
| Homo sapiens | Primates | &TDO | TDO | ncbigene_synonym | DLX3 | 1747 |
| Homo sapiens | Primates | &TDO | TDO | ncbigene_synonym | TDO2 | 6999 |
| Homo sapiens | Primates | КАТ | KAT | ncbigene_synonym | KATNB1 | 10300 |
| Homo sapiens | Primates | КАТ | KAT | ncbigene_synonym | F11R | 50848 |
| Homo sapiens | Primates | КАТ | KAT | ncbigene_synonym | TSTD1 | 100131187 |
| Homo sapiens | Primates | KMO | KMO | ncbigene_symbol | KMO | 8564 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| Trp | NA | mesh:C509690 | ||
| Anthranilic | NA | mesh:C031385 | ||
| 3-NAA | Niacinamide | mesh:D009536 | nicotinamide | chebi:17154 |
| Picolinic Acid | picolinic acid | mesh:C030614 | picolinic acid | chebi:28747 |
| NAD | NAD | mesh:D009243 | NAD(+) | chebi:15846 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|