Mitochondrial sulfide-oxidizing pathway

Mitochondrial sulfide-oxidizing pathway. Scheme depicting the enzymatic components and metabolites involved in sulfide oxidation in the mitochondria. H2S is initially oxidized by sulfide:quinone oxidoreductase (SQR), which transfers electron equivalents to quinones and generates glutathione persulfide (GSSH) as coproduct. Electrons are transferred to O2 via complex III (c.III), cytochrome c (Cc), and complex IV (c.IV), contributing to membrane energization and ATP synthesis. GSSH, with O2 as cosubstrate, is then converted by persulfide dioxygenase (ETHE1) to sulfite (SO32−) and GSH. Sulfite can be converted, with GSSH as cosubstrate, into thiosulfate (S2O32−) by rhodanese (Rhod), or oxidized into sulfate (SO42−) by sulfite oxidase (SOx).

Publication

Hydrogen Sulfide Biochemistry and Interplay with Other Gaseous Mediators in Mammalian Physiology. (2018) Alessandro Giuffrè, et al. Oxid Med Cell Longev. 2018;2018:6290931. Figure: F7. Homo sapiens

Disease mentions