Diagram of core components in the Wg pathway

Diagram of core components in the Wg pathway. (A) In the absence of Wg signaling, Arm is presented by Apc and Axin to CK1 and Zw3/GSK for phosphorylation, targeting it for ubiquitination and degradation by the proteasome. Tcf binds target genes and, with the Gro transcriptional corepressor, keeps expression repressed. (B) Wg, concentrated at the cell surface by glycosaminoglycans on the glypican Dally, binds the Fz and Arrow receptors and causes them to cluster. This allows polymerization of Dsh and Axin at the plasma membrane, inactivating the kinase complex so that it cannot target Arm for destruction. Stabilized Arm translocates into the nucleus, binds to Tcf, and recruits the transcriptional activation complex, which includes Lgs and Pygo. Structural features of proteins depicted here are based on data from , .
Diagram of core components in the Wg pathway
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Publication

Wingless Signaling: A Genetic Journey from Morphogenesis to Metastasis. (2018) Amy Bejsovec. Genetics. 2018 Apr;208(4):1311-1336. Figure: F5.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Drosophila melanogaster Invertebrates ON ON ncbigene_symbol On 252296
Drosophila melanogaster Invertebrates Wg WG ncbigene_symbol wg 34009
Drosophila melanogaster Invertebrates Dally DALLY ncbigene_symbol dally 39013
Drosophila melanogaster Invertebrates OFF OFF ncbigene_symbol Off 249997
Drosophila melanogaster Invertebrates Fz FZ ncbigene_symbol fz 45307
Drosophila melanogaster Invertebrates Dsh DSH ncbigene_symbol dsh 32078
Drosophila melanogaster Invertebrates DEP DEP ncbigene_symbol dep 248306
Drosophila melanogaster Invertebrates DEP DEP ncbigene_synonym DptA 37183
Drosophila melanogaster Invertebrates DEP DEP ncbigene_synonym dve 37546
Drosophila melanogaster Invertebrates Axin AXIN ncbigene_synonym Axn 43565
Drosophila melanogaster Invertebrates Apc APC ncbigene_symbol Apc 44642
Drosophila melanogaster Invertebrates Apc APC ncbigene_synonym Apc2 42871
Drosophila melanogaster Invertebrates Apc APC ncbigene_synonym Fs(3)Apc 49116
Drosophila melanogaster Invertebrates GSK GSK ncbigene_synonym sgg 31248
Drosophila melanogaster Invertebrates CK1 CK1 ncbigene_synonym CkIalpha 32221
Drosophila melanogaster Invertebrates CK1 CK1 ncbigene_synonym gish 49701
Drosophila melanogaster Invertebrates Arm ARM ncbigene_symbol arm 31151
Drosophila melanogaster Invertebrates and AND ncbigene_synonym CkIIbeta 32132
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Andorra 32798
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Anp 43595
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Acam 44913
Drosophila melanogaster Invertebrates Pygo PYGO ncbigene_symbol pygo 43718
Drosophila melanogaster Invertebrates Lgs LGS ncbigene_symbol lgs 43791
Drosophila melanogaster Invertebrates Gro GRO ncbigene_symbol gro 43162
Drosophila melanogaster Invertebrates HMGC HMGC ncbigene_synonym Hmgcr 42803
Drosophila melanogaster Invertebrates Tcf TCF ncbigene_synonym pan 43769
Drosophila melanogaster Invertebrates HMG HMG ncbigene_synonym Dsp1 117294
Homo sapiens Primates Wg WG ncbigene_symbol WG 474168
Homo sapiens Primates Dsh DSH ncbigene_synonym ADAR 103
Homo sapiens Primates Dsh DSH ncbigene_synonym DVL1P1 8215
Homo sapiens Primates Axin AXIN ncbigene_synonym AXIN1 8312
Homo sapiens Primates Axin AXIN famplex_relations AXIN2 8313
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMA1 5682
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMA2 5683
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMA3 5684
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMA4 5685
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMA5 5686
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMA6 5687
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMA7 5688
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMA8 143471
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMB1 5689
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMB10 5699
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMB2 5690
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMB3 5691
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMB4 5692
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMB5 5693
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMB6 5694
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMB7 5695
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMB8 5696
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMB9 5698
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMC1 5700
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMC2 5701
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMC3 5702
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMC4 5704
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMC5 5705
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMC6 5706
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMD1 5707
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMD10 5716
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMD11 5717
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMD12 5718
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMD13 5719
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMD14 10213
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMD2 5708
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMD3 5709
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMD4 5710
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMD5 5711
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMD6 9861
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMD7 5713
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMD8 5714
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMD9 5715
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSME1 5720
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSME2 5721
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSME3 10197
Homo sapiens Primates proteasome PROTEASOME famplex_relations PSMF1 9491
Homo sapiens Primates proteasome PROTEASOME famplex_relations SEM1 7979
Homo sapiens Primates proteasome PROTEASOME famplex_relations USP5 8078
Homo sapiens Primates RGS: RGS ncbigene_synonym PITX2 5308
Homo sapiens Primates Apc APC ncbigene_symbol APC 324
Homo sapiens Primates Apc APC ncbigene_synonym PROC 5624
Homo sapiens Primates CK1 CK1 ncbigene_synonym CSNK1A1 1452
Homo sapiens Primates CK1 CK1 ncbigene_synonym KRT1 3848
Homo sapiens Primates CK1 CK1 ncbigene_synonym CSNK1A1L 122011
Homo sapiens Primates Arm ARM ncbigene_synonym AKR1A1 10327
Homo sapiens Primates Arm ARM ncbigene_synonym ARMC9 80210
Homo sapiens Primates Lgs LGS ncbigene_synonym BCL9 607
Homo sapiens Primates Lgs LGS ncbigene_synonym EXT1 2131
Homo sapiens Primates Lgs LGS ncbigene_synonym LGSN 51557
Homo sapiens Primates Tcf TCF ncbigene_synonym HNF4A 3172
Arabidopsis thaliana Plants and Fungi DEP DEP ncbigene_symbol DEP 843430
Arabidopsis thaliana Plants and Fungi CK1 CK1 ncbigene_symbol CK1 828716
Arabidopsis thaliana Plants and Fungi CK1 CK1 ncbigene_symbol CK1 843500
Arabidopsis thaliana Plants and Fungi HMG HMG ncbigene_symbol HMG 822505

Chemical mentions

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Disease mentions

Word Match MeSH Name DOID