Hippo pathway and cross-talk with other signaling pathways in mammals

Schematic model of the Hippo pathway and cross-talk with other signaling pathways in mammals. The Hippo pathway is a kinase cascade that consists of MST1/2-LATS1/2 and can be activated by diverse stimuli including cell density, polarity and mechanical cues to suppress YAP/TAZ transcriptional activity. Many modulators in the Hippo pathway have been added via multiple approaches (left panel). The crosstalk of the Hippo pathway with other signaling pathways such as Wnt/β-catenin, Notch and TGF-β to regulate YAP/TAZ activity (right panel).
Hippo pathway and cross-talk with other signaling pathways in mammals
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Publication

The history and regulatory mechanism of the Hippo pathway. (2018) Wantae Kim, et al. BMB Rep. 2018 Mar;51(3):106-118. Figure: F3.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Mus musculus Rodents GPCR GPCR ncbigene_synonym Gpbar1 227289
Mus musculus Rodents TGF-B TGFB ncbigene_synonym Tgfb1 21803
Mus musculus Rodents TGF-B TGFB ncbigene_synonym Ltbp1 268977
Mus musculus Rodents Das DAS ncbigene_symbol Das 107419
Mus musculus Rodents Cll CLI ncbigene_synonym Clu 12759
Mus musculus Rodents Cll C11 ncbigene_synonym Polr3k 67005
Mus musculus Rodents Cll C11 ncbigene_synonym Pip4k2b 108083
Mus musculus Rodents KIBRA KIBRA ncbigene_synonym Wwc1 211652
Mus musculus Rodents Rho RHO ncbigene_symbol Rho 212541
Mus musculus Rodents Rho RHO ncbigene_synonym Rhod 11854
Mus musculus Rodents Rho RHO ncbigene_synonym Ea2 104194
Mus musculus Rodents NF2 NF2 ncbigene_symbol Nf2 18016
Mus musculus Rodents AMOT AMOT ncbigene_symbol Amot 27494
Mus musculus Rodents APC APC ncbigene_symbol Apc 11789
Mus musculus Rodents AXIN AXIN ncbigene_synonym Axin1 12005
Mus musculus Rodents MST1 MST1 ncbigene_symbol Mst1 15235
Mus musculus Rodents MST1 MST1 ncbigene_synonym Stk4 58231
Mus musculus Rodents MST1/2 MST2 ncbigene_synonym Stk3 56274
Mus musculus Rodents SAV SAV ncbigene_synonym Sav1 64010
Mus musculus Rodents LATS1 LATS1 ncbigene_symbol Lats1 16798
Mus musculus Rodents LATS1/2 LATS2 ncbigene_symbol Lats2 50523
Mus musculus Rodents B-Catenin CTNNB1 ncbigene_symbol Ctnnb1 12387
Mus musculus Rodents MOB1 MOB1 ncbigene_synonym Cxcl10 15945
Mus musculus Rodents MOB1 MOB1 ncbigene_synonym Mobq1 112052
Mus musculus Rodents MOB1 MOB1 ncbigene_synonym Mob1a 232157
Mus musculus Rodents YAP/TAZ YAP ncbigene_synonym Yap1 22601
Mus musculus Rodents YAP/TAZ TAZ ncbigene_synonym Tafazzin 66826
Mus musculus Rodents YAP/TAZ TAZ ncbigene_synonym Wwtr1 97064
Mus musculus Rodents OGT OGT ncbigene_symbol Ogt 108155
Mus musculus Rodents NLK NLK ncbigene_symbol Nlk 18099
Mus musculus Rodents NLK NLK ncbigene_synonym Gpi1 14751
Mus musculus Rodents PTPN14 PTPN14 ncbigene_symbol Ptpn14 19250
Mus musculus Rodents JAG1 JAG1 ncbigene_symbol Jag1 16449
Mus musculus Rodents VGLL4 VGLL4 ncbigene_symbol Vgll4 232334
Mus musculus Rodents AREG AREG ncbigene_symbol Areg 11839
Homo sapiens Primates GPCR GPCR ncbigene_synonym FZD4 8322
Homo sapiens Primates GPCR GPCR ncbigene_synonym NMUR1 10316
Homo sapiens Primates GPCR GPCR ncbigene_synonym LPAR3 23566
Homo sapiens Primates GPCR GPCR ncbigene_synonym LGR6 59352
Homo sapiens Primates GPCR GPCR ncbigene_synonym MRGPRX3 117195
Homo sapiens Primates GPCR GPCR ncbigene_synonym MRGPRX4 117196
Homo sapiens Primates GPCR GPCR ncbigene_synonym GPR151 134391
Homo sapiens Primates GPCR GPCR ncbigene_synonym OXER1 165140
Homo sapiens Primates GPCR GPCR ncbigene_synonym GPRC6A 222545
Homo sapiens Primates GPCR GPCR ncbigene_synonym MRGPRX1 259249
Homo sapiens Primates GPCR GPCR ncbigene_synonym VN1R17P 441931
Homo sapiens Primates GPCR GPCR ncbigene_synonym GPR166P 442206
Homo sapiens Primates GPCR GPCR famplex_relations GRM1 2911
Homo sapiens Primates GPCR GPCR famplex_relations GRM2 2912
Homo sapiens Primates GPCR GPCR famplex_relations GRM3 2913
Homo sapiens Primates GPCR GPCR famplex_relations GRM4 2914
Homo sapiens Primates GPCR GPCR famplex_relations GRM5 2915
Homo sapiens Primates GPCR GPCR famplex_relations GRM6 2916
Homo sapiens Primates GPCR GPCR famplex_relations GRM7 2917
Homo sapiens Primates GPCR GPCR famplex_relations GRM8 2918
Homo sapiens Primates GPCR GPCR famplex_relations CASR 846
Homo sapiens Primates GPCR GPCR famplex_relations GABBR1 2550
Homo sapiens Primates GPCR GPCR famplex_relations GABBR2 9568
Homo sapiens Primates GPCR GPCR famplex_relations GPR156 165829
Homo sapiens Primates GPCR GPCR famplex_relations GPR158 57512
Homo sapiens Primates GPCR GPCR famplex_relations GPR179 440435
Homo sapiens Primates GPCR GPCR famplex_relations GPRC5A 9052
Homo sapiens Primates GPCR GPCR famplex_relations GPRC5B 51704
Homo sapiens Primates GPCR GPCR famplex_relations GPRC5C 55890
Homo sapiens Primates GPCR GPCR famplex_relations GPRC5D 55507
Homo sapiens Primates NOTCH NOTCH famplex_relations NOTCH1 4851
Homo sapiens Primates NOTCH NOTCH famplex_relations NOTCH2 4853
Homo sapiens Primates NOTCH NOTCH famplex_relations NOTCH3 4854
Homo sapiens Primates NOTCH NOTCH famplex_relations NOTCH4 4855
Homo sapiens Primates TGF-B TGFB ncbigene_synonym TGFB1 7040
Homo sapiens Primates TGF-B TGFB famplex_relations TGFB2 7042
Homo sapiens Primates TGF-B TGFB famplex_relations TGFB3 7043
Homo sapiens Primates WNT WNT famplex_relations WNT1 7471
Homo sapiens Primates WNT WNT famplex_relations WNT2 7472
Homo sapiens Primates WNT WNT famplex_relations WNT2B 7482
Homo sapiens Primates WNT WNT famplex_relations WNT3 7473
Homo sapiens Primates WNT WNT famplex_relations WNT3A 89780
Homo sapiens Primates WNT WNT famplex_relations WNT4 54361
Homo sapiens Primates WNT WNT famplex_relations WNT6 7475
Homo sapiens Primates WNT WNT famplex_relations WNT7A 7476
Homo sapiens Primates WNT WNT famplex_relations WNT7B 7477
Homo sapiens Primates WNT WNT famplex_relations WNT8A 7478
Homo sapiens Primates WNT WNT famplex_relations WNT8B 7479
Homo sapiens Primates WNT WNT famplex_relations WNT9A 7483
Homo sapiens Primates WNT WNT famplex_relations WNT9B 7484
Homo sapiens Primates WNT WNT famplex_relations WNT10A 80326
Homo sapiens Primates WNT WNT famplex_relations WNT10B 7480
Homo sapiens Primates WNT WNT famplex_relations WNT11 7481
Homo sapiens Primates WNT WNT famplex_relations WNT16 51384
Homo sapiens Primates WNT WNT famplex_relations WNT5A 7474
Homo sapiens Primates WNT WNT famplex_relations WNT5B 81029
Homo sapiens Primates Cll CL1 ncbigene_synonym DCLK1 9201
Homo sapiens Primates Cll CL1 ncbigene_synonym ADGRL1 22859
Homo sapiens Primates Cll CLI ncbigene_synonym CLU 1191
Homo sapiens Primates Cll C11 ncbigene_synonym AKR1C4 1109
Homo sapiens Primates Cll C11 ncbigene_synonym GZMB 3002
Homo sapiens Primates Cll C11 ncbigene_synonym POLR3K 51728
Homo sapiens Primates KIBRA KIBRA ncbigene_synonym WWC1 23286
Homo sapiens Primates Rho RHO ncbigene_symbol RHO 6010
Homo sapiens Primates Rho RHO ncbigene_synonym RHOD 29984
Homo sapiens Primates Rho RHO famplex_relations RHOA 387
Homo sapiens Primates Rho RHO famplex_relations RHOB 388
Homo sapiens Primates Rho RHO famplex_relations RHOC 389
Homo sapiens Primates NF2 NF2 ncbigene_symbol NF2 4771
Homo sapiens Primates TAOK TAOK famplex_relations TAOK1 57551
Homo sapiens Primates TAOK TAOK famplex_relations TAOK2 9344
Homo sapiens Primates TAOK TAOK famplex_relations TAOK3 51347
Homo sapiens Primates AMOT AMOT ncbigene_symbol AMOT 154796
Homo sapiens Primates APC APC ncbigene_symbol APC 324
Homo sapiens Primates APC APC ncbigene_synonym PROC 5624
Homo sapiens Primates AXIN AXIN ncbigene_synonym AXIN1 8312
Homo sapiens Primates AXIN AXIN famplex_relations AXIN2 8313
Homo sapiens Primates MST1 MST1 ncbigene_symbol MST1 4485
Homo sapiens Primates MST1 MST1 ncbigene_synonym STK4 6789
Homo sapiens Primates MST1/2 MST2 ncbigene_synonym STK3 6788
Homo sapiens Primates SAV SAV ncbigene_synonym SAV1 60485
Homo sapiens Primates LATS1 LATS1 ncbigene_symbol LATS1 9113
Homo sapiens Primates LATS1/2 LATS2 ncbigene_symbol LATS2 26524
Homo sapiens Primates B-Catenin CTNNB1 ncbigene_symbol CTNNB1 1499
Homo sapiens Primates SMAD SMAD famplex_relations SMAD1 4086
Homo sapiens Primates SMAD SMAD famplex_relations SMAD4 4089
Homo sapiens Primates SMAD SMAD famplex_relations SMAD5 4090
Homo sapiens Primates SMAD SMAD famplex_relations SMAD6 4091
Homo sapiens Primates SMAD SMAD famplex_relations SMAD7 4092
Homo sapiens Primates SMAD SMAD famplex_relations SMAD9 4093
Homo sapiens Primates SMAD SMAD famplex_relations SMAD2 4087
Homo sapiens Primates SMAD SMAD famplex_relations SMAD3 4088
Homo sapiens Primates MOB1 MOB1 ncbigene_synonym CXCL10 3627
Homo sapiens Primates MOB1 MOB1 ncbigene_synonym MOB4 25843
Homo sapiens Primates MOB1 MOB1 ncbigene_synonym MOB1A 55233
Homo sapiens Primates MOB1 MOB1 ncbigene_synonym SGMS1 259230
Homo sapiens Primates MOB1 MOB1 famplex_relations MOB1B 92597
Homo sapiens Primates YAP/TAZ YAP ncbigene_synonym YAP1 10413
Homo sapiens Primates YAP/TAZ TAZ ncbigene_synonym TAFAZZIN 6901
Homo sapiens Primates YAP/TAZ TAZ ncbigene_synonym WWTR1 25937
Homo sapiens Primates OGT OGT ncbigene_symbol OGT 8473
Homo sapiens Primates OGT OGT famplex_relations EOGT 285203
Homo sapiens Primates OGT OGT famplex_relations POMGNT1 55624
Homo sapiens Primates OGT OGT famplex_relations POMGNT2 84892
Homo sapiens Primates NLK NLK ncbigene_symbol NLK 51701
Homo sapiens Primates NLK NLK ncbigene_synonym GPI 2821
Homo sapiens Primates PTPN14 PTPN14 ncbigene_symbol PTPN14 5784
Homo sapiens Primates JAG1 JAG1 ncbigene_symbol JAG1 182
Homo sapiens Primates BMP BMP famplex_relations BMP1 649
Homo sapiens Primates BMP BMP famplex_relations BMP2 650
Homo sapiens Primates BMP BMP famplex_relations BMP3 651
Homo sapiens Primates BMP BMP famplex_relations BMP4 652
Homo sapiens Primates BMP BMP famplex_relations BMP5 653
Homo sapiens Primates BMP BMP famplex_relations BMP6 654
Homo sapiens Primates BMP BMP famplex_relations BMP7 655
Homo sapiens Primates BMP BMP famplex_relations BMP8A 353500
Homo sapiens Primates BMP BMP famplex_relations BMP8B 656
Homo sapiens Primates BMP BMP famplex_relations BMP10 27302
Homo sapiens Primates BMP BMP famplex_relations BMP15 9210
Homo sapiens Primates BMP BMP famplex_relations GDF1 2657
Homo sapiens Primates BMP BMP famplex_relations GDF2 2658
Homo sapiens Primates BMP BMP famplex_relations GDF3 9573
Homo sapiens Primates BMP BMP famplex_relations GDF5 8200
Homo sapiens Primates BMP BMP famplex_relations GDF6 392255
Homo sapiens Primates BMP BMP famplex_relations GDF7 151449
Homo sapiens Primates VGLL4 VGLL4 ncbigene_symbol VGLL4 9686
Homo sapiens Primates AREG AREG ncbigene_symbol AREG 374
Homo sapiens Primates TEAD TEAD famplex_relations TEAD1 7003
Homo sapiens Primates TEAD TEAD famplex_relations TEAD2 8463
Homo sapiens Primates TEAD TEAD famplex_relations TEAD3 7005
Homo sapiens Primates TEAD TEAD famplex_relations TEAD4 7004
Homo sapiens Primates DA3 DA3 ncbigene_synonym PIEZO2 63895
Drosophila melanogaster Invertebrates GPCR GPCR ncbigene_synonym Oamb 43982
Drosophila melanogaster Invertebrates NOTCH NOTCH ncbigene_synonym NA 31293
Drosophila melanogaster Invertebrates TGF-B TGF-B ncbigene_synonym dpp 33432
Drosophila melanogaster Invertebrates TGF-B TGF-B ncbigene_synonym gbb 37778
Drosophila melanogaster Invertebrates TGF-B TGF-B ncbigene_synonym put 41772
Drosophila melanogaster Invertebrates TGF-B TGF-B ncbigene_synonym mav 43804
Drosophila melanogaster Invertebrates WNT WNT ncbigene_synonym Wnt5 32838
Drosophila melanogaster Invertebrates WNT WNT ncbigene_synonym Wnt4 34007
Drosophila melanogaster Invertebrates WNT WNT ncbigene_synonym wg 34009
Drosophila melanogaster Invertebrates WNT WNT ncbigene_synonym Wnt2 35975
Drosophila melanogaster Invertebrates Das DAS ncbigene_synonym nAChRalpha6 34304
Drosophila melanogaster Invertebrates Das DAS ncbigene_synonym Ube3a 39266
Drosophila melanogaster Invertebrates Cll CLL ncbigene_synonym C15 42544
Drosophila melanogaster Invertebrates Cll CLI ncbigene_symbol Cli 5657022
Drosophila melanogaster Invertebrates Cll CLI ncbigene_synonym eya 33916
Drosophila melanogaster Invertebrates KIBRA KIBRA ncbigene_symbol kibra 41783
Drosophila melanogaster Invertebrates Rho RHO ncbigene_symbol rho 38168
Drosophila melanogaster Invertebrates Rho RHO ncbigene_synonym Bx 32846
Drosophila melanogaster Invertebrates Rho RHO ncbigene_synonym Rho1 36775
Drosophila melanogaster Invertebrates Rho RHO ncbigene_synonym Lcp65Ab1 48382
Drosophila melanogaster Invertebrates NF2 NF2 ncbigene_synonym Mer 32979
Drosophila melanogaster Invertebrates APC APC ncbigene_symbol Apc 44642
Drosophila melanogaster Invertebrates APC APC ncbigene_synonym Apc2 42871
Drosophila melanogaster Invertebrates APC APC ncbigene_synonym Axn 43565
Drosophila melanogaster Invertebrates APC APC ncbigene_synonym Fs(3)Apc 49116
Drosophila melanogaster Invertebrates MST1 MST1 ncbigene_synonym Mst57Dc 43121
Drosophila melanogaster Invertebrates MST1 MST1 ncbigene_synonym Mst57Db 43122
Drosophila melanogaster Invertebrates MST1 MST1 ncbigene_synonym Mst57Da 47954
Drosophila melanogaster Invertebrates MST1/2 MST1/2 ncbigene_synonym mst 33119
Drosophila melanogaster Invertebrates MST1/2 MST1/2 ncbigene_synonym hpo 37247
Drosophila melanogaster Invertebrates SAV SAV ncbigene_symbol sav 252554
Drosophila melanogaster Invertebrates LATS1 LATS1 ncbigene_synonym wts 43651
Drosophila melanogaster Invertebrates B-Catenin B-CATENIN ncbigene_synonym arm 31151
Drosophila melanogaster Invertebrates a-Catenin A-CATENIN ncbigene_synonym alpha-Cat 40517
Drosophila melanogaster Invertebrates SMAD SMAD ncbigene_synonym Smox 31738
Drosophila melanogaster Invertebrates SMAD SMAD ncbigene_synonym Mad 33529
Drosophila melanogaster Invertebrates MOB1 MOB1 ncbigene_synonym Mob2 39293
Drosophila melanogaster Invertebrates MOB1 MOB1 ncbigene_synonym mats 42634
Drosophila melanogaster Invertebrates YAP/TAZ YAP/TAZ ncbigene_synonym yki 37851
Drosophila melanogaster Invertebrates TAZ TAZ ncbigene_symbol Taz 36405
Drosophila melanogaster Invertebrates TAZ TAZ ncbigene_synonym Dis3 42900
Drosophila melanogaster Invertebrates OGT OGT ncbigene_synonym sxc 35486
Drosophila melanogaster Invertebrates NLK NLK ncbigene_synonym nmo 38890
Drosophila melanogaster Invertebrates BMP BMP ncbigene_synonym wit 44096
Drosophila melanogaster Invertebrates TEAD TEAD ncbigene_synonym sd 32536
Drosophila melanogaster Invertebrates Jan JAN ncbigene_synonym janB 43568
Drosophila melanogaster Invertebrates Jan JAN ncbigene_synonym janA 43569
Drosophila melanogaster Invertebrates DA3 DA3 ncbigene_synonym nAChRalpha3 31767
Drosophila melanogaster Invertebrates DA3 DA3 ncbigene_synonym Kap-alpha3 41158
Danio rerio Vertebrates Contact CONTACT ncbigene_synonym gdf5 100334210
Danio rerio Vertebrates Rho RHO ncbigene_symbol rho 30295
Danio rerio Vertebrates Rho RHO ncbigene_synonym rnd2 751645
Danio rerio Vertebrates NF2 NF2 ncbigene_synonym nf2b 405887
Danio rerio Vertebrates AMOT AMOT ncbigene_symbol amot 563421
Danio rerio Vertebrates APC APC ncbigene_symbol apc 386762
Danio rerio Vertebrates MST1 MST1 ncbigene_symbol mst1 259260
Danio rerio Vertebrates LATS1 LATS1 ncbigene_symbol lats1 553164
Danio rerio Vertebrates LATS1/2 LATS2 ncbigene_symbol lats2 567674
Danio rerio Vertebrates B-Catenin CTNNB1 ncbigene_symbol ctnnb1 30265
Danio rerio Vertebrates MOB1 MOB1 ncbigene_synonym mob1bb 407654
Danio rerio Vertebrates YAP/TAZ TAZ ncbigene_synonym tafazzin 321965
Danio rerio Vertebrates OGT OGT ncbigene_synonym ogt.1 337685
Danio rerio Vertebrates NLK NLK ncbigene_synonym nlk1 405892
Danio rerio Vertebrates PTPN14 PTPN14 ncbigene_synonym ptpn21 799627
Danio rerio Vertebrates JAG1 JAG1 ncbigene_synonym jag1a 140421
Danio rerio Vertebrates VGLL4 VGLL4 ncbigene_synonym vgll4b 406560
Danio rerio Vertebrates AREG AREG ncbigene_symbol areg 101884611

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID