G protein-coupled receptor 91 signaling in diabetic retinopathy and hypoxic retinal diseases

Working hypothesis of succinate-mediated GPR91 activation pathway in the retinal ganglion cells during the development of DR, ROP, and hypoxic retinal diseases ( adopted from doctoral dissertation of Jianyan Hu, School of Medicine, Shanghai Jiaotong University )
G protein-coupled receptor 91 signaling in diabetic retinopathy and hypoxic retinal diseases
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Publication

G protein-coupled receptor 91 signaling in diabetic retinopathy and hypoxic retinal diseases. () Jianyan Hu, et al. Vision Res. ;139:59-64. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates ERK1 ERK1 ncbigene_synonym MAPK3 5595
Homo sapiens Primates ERK1/2 ERK2 ncbigene_synonym MAPK1 5594
Homo sapiens Primates MAPK MAPK famplex_relations MAPK11 5600
Homo sapiens Primates MAPK MAPK famplex_relations MAPK12 6300
Homo sapiens Primates MAPK MAPK famplex_relations MAPK13 5603
Homo sapiens Primates MAPK MAPK famplex_relations MAPK14 1432
Homo sapiens Primates MAPK MAPK famplex_relations MAPK8 5599
Homo sapiens Primates MAPK MAPK famplex_relations MAPK9 5601
Homo sapiens Primates MAPK MAPK famplex_relations MAPK10 5602
Homo sapiens Primates p38 P38 ncbigene_synonym CRK 1398
Homo sapiens Primates p38 P38 ncbigene_synonym AIMP2 7965
Homo sapiens Primates p38 P38 ncbigene_synonym GRAP2 9402
Homo sapiens Primates p38 P38 ncbigene_synonym AHSA1 10598
Homo sapiens Primates p38 P38 ncbigene_synonym POLDIP2 26073
Homo sapiens Primates AP1 AP1 ncbigene_synonym FOS 2353
Homo sapiens Primates AP1 AP1 ncbigene_synonym FOSB 2354
Homo sapiens Primates AP1 AP1 ncbigene_synonym JUN 3725
Homo sapiens Primates AP1 AP1 ncbigene_synonym JUNB 3726
Homo sapiens Primates AP1 AP1 ncbigene_synonym JUND 3727
Homo sapiens Primates AP1 AP1 famplex_relations FOSL1 8061
Homo sapiens Primates AP1 AP1 famplex_relations FOSL2 2355
Homo sapiens Primates EBP EBP ncbigene_symbol EBP 10682
Homo sapiens Primates EBP EBP ncbigene_synonym GLB1 2720
Homo sapiens Primates EBP EBP ncbigene_synonym SH3D19 152503
Homo sapiens Primates VEGF VEGF ncbigene_synonym VEGFA 7422
Homo sapiens Primates VEGF VEGF famplex_relations VEGFB 7423
Homo sapiens Primates VEGF VEGF famplex_relations VEGFC 7424
Homo sapiens Primates VEGF VEGF famplex_relations VEGFD 2277
Homo sapiens Primates VEGF VEGF famplex_relations PGF 5228
Mus musculus Rodents ERK1 ERK1 ncbigene_synonym Mapk3 26417
Mus musculus Rodents ERK1/2 ERK2 ncbigene_synonym Mapk1 26413
Mus musculus Rodents p38MAPK P38MAPK ncbigene_synonym Mapk14 26416
Mus musculus Rodents p38 P38 ncbigene_synonym Crk 12928
Mus musculus Rodents p38 P38 ncbigene_synonym Grap2 17444
Mus musculus Rodents p38 P38 ncbigene_synonym Syp 20977
Mus musculus Rodents p38 P38 ncbigene_synonym Ahsa1 217737
Mus musculus Rodents JNK JNK ncbigene_synonym Mapk8 26419
Mus musculus Rodents AP1 AP1 ncbigene_synonym Jun 16476
Mus musculus Rodents EBP EBP ncbigene_symbol Ebp 13595
Mus musculus Rodents VEGF VEGF ncbigene_synonym Vegfa 22339
Rattus norvegicus Rodents ERK1 ERK1 ncbigene_synonym Mapk3 50689
Rattus norvegicus Rodents ERK1/2 ERK2 ncbigene_synonym Mapk1 116590
Rattus norvegicus Rodents p38 P38 ncbigene_synonym Mapk14 81649
Rattus norvegicus Rodents JNK JNK ncbigene_synonym Mapk8 116554
Rattus norvegicus Rodents C/EBP C/EBP ncbigene_synonym Cebpg 25301
Rattus norvegicus Rodents EBP EBP ncbigene_symbol Ebp 117278
Rattus norvegicus Rodents VEGF VEGF ncbigene_synonym Vegfa 83785
Arabidopsis thaliana Plants and Fungi Нуроxia XIA ncbigene_symbol XIA 839480
Arabidopsis thaliana Plants and Fungi AP1 AP1 ncbigene_symbol AP1 843244
Arabidopsis thaliana Plants and Fungi EBP EBP ncbigene_symbol EBP 820929

Chemical mentions

Word Match MeSH Name ChEBI
U0126 U0126 mesh:C113580 U 0126 chebi:90693
PGE Prostaglandins E mesh:D011458 prostaglandins E chebi:26338
Retinal Retinaldehyde mesh:D012172 all-trans-retinal chebi:17898

Disease mentions

Word Match MeSH Name DOID