Siglec-G/10 in the immune regulation of sepsis

Siglec-G/10 in the immune regulation of sepsis. (A) Siglec-G decreases the inflammation induced by DAMPs through NF-κB signal pathway with the help of CD24. (B) Siglec-G inhibits CD 8T cells proliferation through impairing MHC class I-peptide complexes formation. (C) Siglec-10 increases IL-10 production through MyD88 and p38 MAPK signaling pathways in Campylobacter jejuni infection. DAMPs, danger-associated molecular patterns; TLRs, toll-like receptors; NF-κB, nuclear factor-kappa B; MHC, major histocompatibility complex; MyD, myeloid differentiation factor; MAPK, mitogen-activated protein kinase; IL-10, interleukin 10.
Siglec-G/10 in the immune regulation of sepsis
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Publication

Sialic Acids in the Immune Response during Sepsis. (2017) Yan-Cun Liu, et al. Front Immunol. 2017;8:1601. Figure: F3.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Drosophila melanogaster Invertebrates MHC MHC ncbigene_symbol Mhc 35007
Drosophila melanogaster Invertebrates MHC MHC ncbigene_synonym zip 38001
Drosophila melanogaster Invertebrates MYD88 MYD88 ncbigene_symbol Myd88 35956
Drosophila melanogaster Invertebrates NF-KB NF-KB ncbigene_synonym Dif 35045
Drosophila melanogaster Invertebrates NF-KB NF-KB ncbigene_synonym dl 35047
Drosophila melanogaster Invertebrates NF-KB NF-KB ncbigene_synonym Rel 41087
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym MKP-4 32963
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym p38b 34780
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym rl 3354888
Drosophila melanogaster Invertebrates P38 P38 ncbigene_synonym lic 32257
Drosophila melanogaster Invertebrates P38 P38 ncbigene_synonym Nurf-38 37922
Drosophila melanogaster Invertebrates P38 P38 ncbigene_synonym Ebp 38009
Drosophila melanogaster Invertebrates P38 P38 ncbigene_synonym AIMP2 39690
Drosophila melanogaster Invertebrates P38 P38 ncbigene_synonym p38a 42866
Drosophila melanogaster Invertebrates P38 P38 ncbigene_synonym Hrb87F 48535
Drosophila melanogaster Invertebrates P38 P38 ncbigene_synonym p38c 2768679
Drosophila melanogaster Invertebrates SHP- SHP ncbigene_symbol shp 252637
Homo sapiens Primates CD8 CD8 ncbigene_synonym CD8A 925
Homo sapiens Primates CD8 CD8 famplex_relations CD8B 926
Homo sapiens Primates CD24 CD24 ncbigene_symbol CD24 100133941
Homo sapiens Primates Siglec-10 SIGLEC-10 ncbigene_synonym SIGLEC10 89790
Homo sapiens Primates MHC MHC ncbigene_synonym HLA-C 3107
Homo sapiens Primates SHP-1 SHP-1 ncbigene_synonym PTPN6 5777
Homo sapiens Primates MYD88 MYD88 ncbigene_symbol MYD88 4615
Homo sapiens Primates NF-KB NF-KB ncbigene_synonym NFKB1 4790
Homo sapiens Primates MAPK MAPK famplex_relations MAPK1 5594
Homo sapiens Primates MAPK MAPK famplex_relations MAPK3 5595
Homo sapiens Primates MAPK MAPK famplex_relations MAPK11 5600
Homo sapiens Primates MAPK MAPK famplex_relations MAPK12 6300
Homo sapiens Primates MAPK MAPK famplex_relations MAPK13 5603
Homo sapiens Primates MAPK MAPK famplex_relations MAPK14 1432
Homo sapiens Primates MAPK MAPK famplex_relations MAPK8 5599
Homo sapiens Primates MAPK MAPK famplex_relations MAPK9 5601
Homo sapiens Primates MAPK MAPK famplex_relations MAPK10 5602
Homo sapiens Primates P38 P38 ncbigene_synonym CRK 1398
Homo sapiens Primates P38 P38 ncbigene_synonym AIMP2 7965
Homo sapiens Primates P38 P38 ncbigene_synonym GRAP2 9402
Homo sapiens Primates P38 P38 ncbigene_synonym AHSA1 10598
Homo sapiens Primates P38 P38 ncbigene_synonym POLDIP2 26073
Homo sapiens Primates PHỊ PHI ncbigene_synonym GPI 2821
Homo sapiens Primates SHP- SHP ncbigene_synonym NR0B2 8431
Homo sapiens Primates p47phox P47PHOX ncbigene_synonym NCF1 653361

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID