Schematic illustrating the G protein-independent role of RGS6 in doxorubicin-induced apoptosis and antiproliferative signaling in the breast

Schematic illustrating the G protein-independent role of RGS6 in doxorubicin-induced apoptosis and antiproliferative signaling in the breast. a RGS6 is induced by doxorubicin (Dox) treatment and functions as a critical upstream mediator of reactive oxygen species (ROS)-dependent activation of the ataxia telangiectasia-mutated (ATM)-p53-apoptotic pathway in both mouse embryonic fibroblasts and breast cancer cells. Whether the RGS6-dependent upregulation of p53 in response to Dox induces autophagy by DNA-damage regulated autophagy modulator 1 (DRAM1) is unknown. b RGS6 is also a multifunctional tumor suppressor that simultaneously inhibits cell cycle progression and pro-growth signal downstream of human epidermal growth factor receptor 2 (HER2) and the estrogen receptor (ER). In addition, RGS6 functions as a scaffold protein to promote Tip60-mediated DNA (cytosine-5)-methyltransferase 1 (DNMT1) acetylation leading to its degradation and preventing DNMT1 silencing of pro-apoptotic genes. This represents an essential role of RGS6 in preventing reticular activating system (Ras)-induced oncogenesis. R7BP R7 family-binding protein, DMAP1 DNA methyltransferase1 associated protein 1, Met methylation, Ub ubiquitin, Ac acetylation, ERE estrogen response element. Image adapted from references (, , )
Schematic illustrating the G protein-independent role of RGS6 in doxorubicin-induced apoptosis and antiproliferative signaling in the breast

Publication

RGS6 as a Novel Therapeutic Target in CNS Diseases and Cancer. (2016) Katelin E. Ahlers, et al. AAPS J. 2016 May;18(3):560-572. Figure: F6.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Drosophila melanogaster Invertebrates DOX DOX ncbigene_synonym Rpn3 35176
Drosophila melanogaster Invertebrates DOX DOX ncbigene_synonym Dox-3 8680163
Drosophila melanogaster Invertebrates Ras RAS ncbigene_symbol ras 43873
Drosophila melanogaster Invertebrates Ras RAS ncbigene_synonym Ras64B 38494
Drosophila melanogaster Invertebrates Ras RAS ncbigene_synonym Ras85D 41140
Drosophila melanogaster Invertebrates ATM ATM ncbigene_synonym tefu 41839
Drosophila melanogaster Invertebrates p53 P53 ncbigene_symbol p53 2768677
Drosophila melanogaster Invertebrates p53 P53 ncbigene_synonym betaTub60D 37888
Drosophila melanogaster Invertebrates p53 P53 ncbigene_synonym hth 41273
Drosophila melanogaster Invertebrates DEP DEP ncbigene_symbol dep 248306
Drosophila melanogaster Invertebrates DEP DEP ncbigene_synonym DptA 37183
Drosophila melanogaster Invertebrates DEP DEP ncbigene_synonym dve 37546
Drosophila melanogaster Invertebrates GB, GB ncbigene_symbol gb 43265
Drosophila melanogaster Invertebrates GB, GB ncbigene_synonym Gbeta5 31744
Drosophila melanogaster Invertebrates GB, GB ncbigene_synonym Gbeta13F 32544
Drosophila melanogaster Invertebrates GB, GB ncbigene_synonym Gbeta76C 40148
Drosophila melanogaster Invertebrates Caspase3 CASPASE3 ncbigene_synonym Decay 42008
Drosophila melanogaster Invertebrates Tip60 TIP60 ncbigene_symbol Tip60 31362
Homo sapiens Primates HER2 HER2 ncbigene_synonym ERBB2 2064
Homo sapiens Primates Ras RAS famplex_relations KRAS 3845
Homo sapiens Primates Ras RAS famplex_relations HRAS 3265
Homo sapiens Primates Ras RAS famplex_relations NRAS 4893
Homo sapiens Primates RGS6 RGS6 ncbigene_symbol RGS6 9628
Homo sapiens Primates ATM ATM ncbigene_symbol ATM 472
Homo sapiens Primates p53 P53 ncbigene_synonym TP53 7157
Homo sapiens Primates p53 P53 famplex_relations TP63 8626
Homo sapiens Primates p53 P53 famplex_relations TP73 7161
Homo sapiens Primates Bax BAX ncbigene_symbol BAX 581
Homo sapiens Primates DRAM1 DRAM1 ncbigene_symbol DRAM1 55332
Homo sapiens Primates R7BP R7BP ncbigene_synonym RGS7BP 401190
Homo sapiens Primates GB, GB ncbigene_synonym SUCLG2 8801
Homo sapiens Primates GB, GB famplex_relations GNB1 2782
Homo sapiens Primates GB, GB famplex_relations GNB2 2783
Homo sapiens Primates GB, GB famplex_relations GNB3 2784
Homo sapiens Primates GB, GB famplex_relations GNB4 59345
Homo sapiens Primates GB, GB famplex_relations GNB5 10681
Homo sapiens Primates Caspase CASPASE famplex_relations CASP1 834
Homo sapiens Primates Caspase CASPASE famplex_relations CASP2 835
Homo sapiens Primates Caspase CASPASE famplex_relations CASP4 837
Homo sapiens Primates Caspase CASPASE famplex_relations CASP5 838
Homo sapiens Primates Caspase CASPASE famplex_relations CASP6 839
Homo sapiens Primates Caspase CASPASE famplex_relations CASP8 841
Homo sapiens Primates Caspase CASPASE famplex_relations CASP9 842
Homo sapiens Primates Caspase CASPASE famplex_relations CASP10 843
Homo sapiens Primates Caspase CASPASE famplex_relations CASP12 100506742
Homo sapiens Primates Caspase CASPASE famplex_relations CASP14 23581
Homo sapiens Primates Caspase CASPASE famplex_relations CASP3 836
Homo sapiens Primates Caspase CASPASE famplex_relations CASP7 840
Homo sapiens Primates Tip60 TIP60 ncbigene_synonym KAT5 10524
Homo sapiens Primates RGS RGS ncbigene_synonym PITX2 5308

Chemical mentions

Word Match MeSH Name ChEBI
Met Met NA mesh:D008715

Disease mentions

Word Match MeSH Name DOID
Cancer NA
Lung cancer NA