Wnt/Beta-catenin signaling
Wnt/β-catenin signaling. Upon ligation with Wnt to frizzled receptor, Wnt/β-catenin signaling pathway gets activated. This results in breakdown of the destruction complex thereby stabilizing β-catenin. Accumulated β-catenin in nucleus acts as a co-activator of TCF family of transcription factors and initiate transcription of Wnt related genes
Publication
Wnt Signaling: Role in Regulation of Haematopoiesis. (2016) Ram Babu Undi, et al. Indian J Hematol Blood Transfus. 2016 Jun;32(2):123-134. Figure: F3.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | Dvl | DVL | ncbigene_synonym | DVL1 | 1855 |
| Homo sapiens | Primates | Dvl | DVL | ncbigene_synonym | DVL1P1 | 8215 |
| Homo sapiens | Primates | Dvl | DVL | famplex_relations | DVL2 | 1856 |
| Homo sapiens | Primates | Dvl | DVL | famplex_relations | DVL3 | 1857 |
| Homo sapiens | Primates | Dvl | DV1 | ncbigene_synonym | IFT81 | 28981 |
| Homo sapiens | Primates | Axin | AXIN | ncbigene_synonym | AXIN1 | 8312 |
| Homo sapiens | Primates | Axin | AXIN | famplex_relations | AXIN2 | 8313 |
| Homo sapiens | Primates | APC | APC | ncbigene_symbol | APC | 324 |
| Homo sapiens | Primates | APC | APC | ncbigene_synonym | PROC | 5624 |
| Homo sapiens | Primates | GSK-3ß | GSK3 | famplex_relations | GSK3A | 2931 |
| Homo sapiens | Primates | GSK-3ß | GSK3 | famplex_relations | GSK3B | 2932 |
| Homo sapiens | Primates | B-Catenin | CTNNB1 | ncbigene_symbol | CTNNB1 | 1499 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT1 | 7471 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT2 | 7472 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT2B | 7482 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT3 | 7473 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT3A | 89780 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT4 | 54361 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT6 | 7475 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT7A | 7476 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT7B | 7477 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT8A | 7478 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT8B | 7479 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT9A | 7483 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT9B | 7484 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT10A | 80326 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT10B | 7480 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT11 | 7481 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT16 | 51384 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT5A | 7474 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT5B | 81029 |
| Homo sapiens | Primates | TCF1 | TCF1 | ncbigene_synonym | HNF1A | 6927 |
| Homo sapiens | Primates | TCF1 | TCF1 | ncbigene_synonym | TCF7 | 6932 |
| Word | Match | MeSH | Name | ChEBI |
|---|
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|