MAPK pathway has been invoked in phospholipase A2 activity that could release arachidonic acid, perhaps in concert with VEGF, and thereby amplify 20-HETE formation ()

The MAPK pathway has been invoked in phospholipase A2 activity that could release arachidonic acid, perhaps in concert with VEGF, and thereby amplify 20-HETE formation (). Other critical elements of CYP4:20-HETE cancer signaling include activation of PI3K/Akt (), as well as roles for HIF-1α and reactive oxygen species (ROS) (). Very recently, Zeldin and coworkers generated a CYP4F2 transgenic mouse with selective endothelial cell expression (). Endothelial cells from transgenic animals exhibited twofold increases in levels of 20-HETE, increased growth and tube formation with upregulation of VEGF and the prooxidant enzyme NADPH oxidase, further underlining the importance of the MAPK pathway and ROS in cellular proliferation. attempts to capture essential elements of the complex signaling pathways of CYP4:20-HETE in cancer progression. More detailed mechanistic proposals can be found in two excellent recent reviews (; )

Publication

Cytochrome P450 ω-Hydroxylases in Inflammation and Cancer. () Amanda L. Johnson, et al. Adv Pharmacol. ;74:223-262. Figure: F5. All organisms Homo sapiens Bos taurus Mus musculus Rattus norvegicus Drosophila melanogaster

Disease mentions