Possible pathways of Cd-induced MAPK/ERK signaling

Possible pathways of Cd-induced MAPK/ERK signaling. (1) The interaction of Cd with membrane ERα leads to EGFR-mediated activation of MAPK with the assistance of G-proteins, Src kinase, MMP-9/-2, and HB-EGF. (2) ERα regulates adaptor protein Gab2 which enhances MAPK/ERK signaling. (3) Cd interacts with an un-identified membrane receptor that sends signal to Raf whose activity is controlled by the basal activities of EGFR and Src kinase.
Possible pathways of Cd-induced MAPK/ERK signaling
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Publication

Requirement of ERα and Basal Activities of EGFR and Src Kinase in Cd-induced Activation of MAPK/ERK Pathway in Human Breast Cancer MCF-7 Cells. () Xiulong Song, et al. Toxicol Appl Pharmacol. ;287(1):26-34. Figure: F10.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Oryctolagus cuniculus Mammals HB-EGF HBEGF ncbigene_symbol HBEGF 100008809
Oryctolagus cuniculus Mammals Cd2+ CD2 ncbigene_symbol CD2 100348754
Oryctolagus cuniculus Mammals MMP-9 MMP9 ncbigene_symbol MMP9 100008993
Oryctolagus cuniculus Mammals MMP-2 MMP2 ncbigene_symbol MMP2 100009000
Oryctolagus cuniculus Mammals EGFR EGFR ncbigene_symbol EGFR 100008806
Oryctolagus cuniculus Mammals Grb2 GRB2 ncbigene_symbol GRB2 100342500
Oryctolagus cuniculus Mammals Src. SRC ncbigene_symbol SRC 100341599
Oryctolagus cuniculus Mammals SRF SRF ncbigene_symbol SRF 100354695
Oryctolagus cuniculus Mammals ELK-1 ELK1 ncbigene_symbol ELK1 100340952
Oryctolagus cuniculus Mammals Gab2 GAB2 ncbigene_symbol GAB2 100349301
Bos taurus Mammals HB-EGF HB-EGF ncbigene_synonym HBEGF 522921
Bos taurus Mammals Cd2+ CD2 ncbigene_symbol CD2 497022
Bos taurus Mammals MMP-9 MMP9 ncbigene_symbol MMP9 282871
Bos taurus Mammals MMP-2 MMP2 ncbigene_symbol MMP2 282872
Bos taurus Mammals EGFR EGFR ncbigene_symbol EGFR 407217
Bos taurus Mammals Grb2 GRB2 ncbigene_symbol GRB2 535298
Bos taurus Mammals Src. SRC ncbigene_symbol SRC 535742
Bos taurus Mammals ERK1/2 ERK1 ncbigene_synonym MAPK3 531391
Bos taurus Mammals ERK1/2 ERK2 ncbigene_synonym MAPK1 327672
Bos taurus Mammals SRF SRF ncbigene_symbol SRF 533039
Bos taurus Mammals ELK-1 ELK1 ncbigene_symbol ELK1 786886
Bos taurus Mammals Gab2 GAB2 ncbigene_symbol GAB2 529346
Homo sapiens Primates HB-EGF HBEGF ncbigene_symbol HBEGF 1839
Homo sapiens Primates Cd2+ CD2 ncbigene_symbol CD2 914
Homo sapiens Primates MMP-9 MMP-9 ncbigene_synonym MMP9 4318
Homo sapiens Primates MMP-2 MMP-2 ncbigene_synonym MMP2 4313
Homo sapiens Primates EGFR EGFR ncbigene_symbol EGFR 1956
Homo sapiens Primates Shc SHC ncbigene_synonym SHC1 6464
Homo sapiens Primates Shc SHC famplex_relations SHC2 25759
Homo sapiens Primates Shc SHC famplex_relations SHC3 53358
Homo sapiens Primates Shc SHC famplex_relations SHC4 399694
Homo sapiens Primates Grb2 GRB2 ncbigene_symbol GRB2 2885
Homo sapiens Primates ERa ERA ncbigene_synonym ESR1 2099
Homo sapiens Primates ERa ERA ncbigene_synonym ERAL1 26284
Homo sapiens Primates Src. SRC ncbigene_symbol SRC 6714
Homo sapiens Primates Src. SRC famplex_relations FGR 2268
Homo sapiens Primates Src. SRC famplex_relations FYN 2534
Homo sapiens Primates Src. SRC famplex_relations YES1 7525
Homo sapiens Primates Sos SOS ncbigene_synonym XYLT2 64132
Homo sapiens Primates Sos SOS famplex_relations SOS1 6654
Homo sapiens Primates Sos SOS famplex_relations SOS2 6655
Homo sapiens Primates Raf RAF ncbigene_synonym ZHX2 22882
Homo sapiens Primates Raf RAF famplex_relations ARAF 369
Homo sapiens Primates Raf RAF famplex_relations BRAF 673
Homo sapiens Primates Raf RAF famplex_relations RAF1 5894
Homo sapiens Primates Ras RAS famplex_relations KRAS 3845
Homo sapiens Primates Ras RAS famplex_relations HRAS 3265
Homo sapiens Primates Ras RAS famplex_relations NRAS 4893
Homo sapiens Primates MEK MEK ncbigene_synonym MAP2K7 5609
Homo sapiens Primates MEK MEK famplex_relations MAP2K1 5604
Homo sapiens Primates MEK MEK famplex_relations MAP2K2 5605
Homo sapiens Primates ERK ERK ncbigene_synonym EPHB2 2048
Homo sapiens Primates ERK ERK ncbigene_synonym MAPK1 5594
Homo sapiens Primates ERK ERK famplex_relations MAPK3 5595
Homo sapiens Primates SRF SRF ncbigene_symbol SRF 6722
Homo sapiens Primates ELK-1 ELK1 ncbigene_symbol ELK1 2002
Homo sapiens Primates ELK-1 ELK1 ncbigene_synonym KCNH4 23415
Homo sapiens Primates ELK-1 ELK1 ncbigene_synonym KCNH8 131096
Homo sapiens Primates Gab2 GAB2 ncbigene_symbol GAB2 9846
Drosophila melanogaster Invertebrates Cd CD ncbigene_symbol cd 42681
Drosophila melanogaster Invertebrates MMP-2 MMP2 ncbigene_symbol Mmp2 35997
Drosophila melanogaster Invertebrates EGFR EGFR ncbigene_symbol Egfr 37455
Drosophila melanogaster Invertebrates Shc SHC ncbigene_symbol Shc 44052
Drosophila melanogaster Invertebrates Grb2 GRB2 ncbigene_synonym drk 36497
Drosophila melanogaster Invertebrates ERa ERA ncbigene_symbol era 5658294
Drosophila melanogaster Invertebrates Src. SRC ncbigene_synonym Src42A 35524
Drosophila melanogaster Invertebrates Src. SRC ncbigene_synonym Csk 41398
Drosophila melanogaster Invertebrates Src. SRC ncbigene_synonym Src64B 48973
Drosophila melanogaster Invertebrates Gai GAI ncbigene_symbol Galphai 38765
Drosophila melanogaster Invertebrates Sos SOS ncbigene_symbol Sos 34790
Drosophila melanogaster Invertebrates Raf RAF ncbigene_symbol Raf 31221
Drosophila melanogaster Invertebrates Ras RAS ncbigene_symbol ras 43873
Drosophila melanogaster Invertebrates Ras RAS ncbigene_synonym Ras64B 38494
Drosophila melanogaster Invertebrates Ras RAS ncbigene_synonym Ras85D 41140
Drosophila melanogaster Invertebrates MEK MEK ncbigene_synonym Dsor1 31872
Drosophila melanogaster Invertebrates MEK MEK ncbigene_synonym Mtk 36708
Drosophila melanogaster Invertebrates ERK ERK ncbigene_synonym Erk7 31877
Drosophila melanogaster Invertebrates ERK ERK ncbigene_synonym rl 3354888
Drosophila melanogaster Invertebrates SRF SRF ncbigene_symbol Srf 252723
Drosophila melanogaster Invertebrates SRF SRF ncbigene_synonym mal 33045
Drosophila melanogaster Invertebrates SRF SRF ncbigene_synonym bs 37890

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID
Cancer NA
Cardiomyopathy NA
Lung cancer NA
Noonan syndrome NA