Transcriptional regulation of cranial sensory placode development

During gastrulation, early, high BMP levels activate several NB-specifying genes and low BMP levels, controlled by the secretion of BMP antagonists, allow the expression of neural genes (e.g., SoxB1 transcription factors). The NB-specifying genes interact with each other to promote (black arrows) the formation of the NB zone, and they repress (red bars) the expression of neural genes. Indicated are the various interactions, described in the text, that result in the separation of the NB zone into the neural crest and the pre-placodal ectoderm (PPE). Contributing to this separation are several signaling pathways. Later, high levels of BMP promote an epidermal fate, but this pathway must be attenuated to produce neural crest and PPE. An FGF pulse is required for PPE formation. Wnt postitively regulates neural crest formation and represses PPE formation.
Transcriptional regulation of cranial sensory placode development
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Publication

Transcriptional regulation of cranial sensory placode development. () Sally A. Moody, et al. Curr Top Dev Biol. ;111:301-350. Figure: F3.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates BMP BMP famplex_relations BMP1 649
Homo sapiens Primates BMP BMP famplex_relations BMP2 650
Homo sapiens Primates BMP BMP famplex_relations BMP3 651
Homo sapiens Primates BMP BMP famplex_relations BMP4 652
Homo sapiens Primates BMP BMP famplex_relations BMP5 653
Homo sapiens Primates BMP BMP famplex_relations BMP6 654
Homo sapiens Primates BMP BMP famplex_relations BMP7 655
Homo sapiens Primates BMP BMP famplex_relations BMP8A 353500
Homo sapiens Primates BMP BMP famplex_relations BMP8B 656
Homo sapiens Primates BMP BMP famplex_relations BMP10 27302
Homo sapiens Primates BMP BMP famplex_relations BMP15 9210
Homo sapiens Primates BMP BMP famplex_relations GDF1 2657
Homo sapiens Primates BMP BMP famplex_relations GDF2 2658
Homo sapiens Primates BMP BMP famplex_relations GDF3 9573
Homo sapiens Primates BMP BMP famplex_relations GDF5 8200
Homo sapiens Primates BMP BMP famplex_relations GDF6 392255
Homo sapiens Primates BMP BMP famplex_relations GDF7 151449
Homo sapiens Primates Msx1 MSX1 ncbigene_symbol MSX1 4487
Homo sapiens Primates Foxi1 FOXI1 ncbigene_symbol FOXI1 2299
Homo sapiens Primates TFAP2 TFAP2 ncbigene_synonym TFAP2A 7020
Homo sapiens Primates TFAP2 TFAP2 famplex_relations TFAP2B 7021
Homo sapiens Primates TFAP2 TFAP2 famplex_relations TFAP2C 7022
Homo sapiens Primates TFAP2 TFAP2 famplex_relations TFAP2D 83741
Homo sapiens Primates TFAP2 TFAP2 famplex_relations TFAP2E 339488
Homo sapiens Primates Zic1 ZIC1 ncbigene_symbol ZIC1 7545
Homo sapiens Primates crest CREST ncbigene_synonym SS18L1 26039
Homo sapiens Primates Wnt WNT famplex_relations WNT1 7471
Homo sapiens Primates Wnt WNT famplex_relations WNT2 7472
Homo sapiens Primates Wnt WNT famplex_relations WNT2B 7482
Homo sapiens Primates Wnt WNT famplex_relations WNT3 7473
Homo sapiens Primates Wnt WNT famplex_relations WNT3A 89780
Homo sapiens Primates Wnt WNT famplex_relations WNT4 54361
Homo sapiens Primates Wnt WNT famplex_relations WNT6 7475
Homo sapiens Primates Wnt WNT famplex_relations WNT7A 7476
Homo sapiens Primates Wnt WNT famplex_relations WNT7B 7477
Homo sapiens Primates Wnt WNT famplex_relations WNT8A 7478
Homo sapiens Primates Wnt WNT famplex_relations WNT8B 7479
Homo sapiens Primates Wnt WNT famplex_relations WNT9A 7483
Homo sapiens Primates Wnt WNT famplex_relations WNT9B 7484
Homo sapiens Primates Wnt WNT famplex_relations WNT10A 80326
Homo sapiens Primates Wnt WNT famplex_relations WNT10B 7480
Homo sapiens Primates Wnt WNT famplex_relations WNT11 7481
Homo sapiens Primates Wnt WNT famplex_relations WNT16 51384
Homo sapiens Primates Wnt WNT famplex_relations WNT5A 7474
Homo sapiens Primates Wnt WNT famplex_relations WNT5B 81029
Homo sapiens Primates FGF FGF famplex_relations FGF1 2246
Homo sapiens Primates FGF FGF famplex_relations FGF2 2247
Homo sapiens Primates FGF FGF famplex_relations FGF3 2248
Homo sapiens Primates FGF FGF famplex_relations FGF4 2249
Homo sapiens Primates FGF FGF famplex_relations FGF5 2250
Homo sapiens Primates FGF FGF famplex_relations FGF6 2251
Homo sapiens Primates FGF FGF famplex_relations FGF7 2252
Homo sapiens Primates FGF FGF famplex_relations FGF8 2253
Homo sapiens Primates FGF FGF famplex_relations FGF9 2254
Homo sapiens Primates FGF FGF famplex_relations FGF10 2255
Homo sapiens Primates FGF FGF famplex_relations FGF11 2256
Homo sapiens Primates FGF FGF famplex_relations FGF12 2257
Homo sapiens Primates FGF FGF famplex_relations FGF13 2258
Homo sapiens Primates FGF FGF famplex_relations FGF14 2259
Homo sapiens Primates FGF FGF famplex_relations FGF16 8823
Homo sapiens Primates FGF FGF famplex_relations FGF17 8822
Homo sapiens Primates FGF FGF famplex_relations FGF18 8817
Homo sapiens Primates FGF FGF famplex_relations FGF19 9965
Homo sapiens Primates FGF FGF famplex_relations FGF20 26281
Homo sapiens Primates FGF FGF famplex_relations FGF21 26291
Homo sapiens Primates FGF FGF famplex_relations FGF22 27006
Homo sapiens Primates FGF FGF famplex_relations FGF23 8074
Mus musculus Rodents Msx1 MSX1 ncbigene_symbol Msx1 17701
Mus musculus Rodents Dlx DLX ncbigene_synonym Dlx1 13390
Mus musculus Rodents Foxi1 FOXI1 ncbigene_symbol Foxi1 14233
Mus musculus Rodents Zic1 ZIC1 ncbigene_symbol Zic1 22771
Mus musculus Rodents crest CREST ncbigene_synonym Ss18l1 269397
Gallus gallus Vertebrates Msx1 MSX1 ncbigene_symbol MSX1 396484
Gallus gallus Vertebrates Foxi1 FOXI1 ncbigene_symbol FOXI1 427613
Gallus gallus Vertebrates TFAP2 TFAP2 ncbigene_synonym TFAP2A 395982
Gallus gallus Vertebrates Zic1 ZIC1 ncbigene_symbol ZIC1 374103
Gallus gallus Vertebrates FGF FGF ncbigene_synonym FGF10 395432
Drosophila melanogaster Invertebrates BMP BMP ncbigene_synonym dpp 33432
Drosophila melanogaster Invertebrates BMP BMP ncbigene_synonym gbb 37778
Drosophila melanogaster Invertebrates BMP BMP ncbigene_synonym wit 44096
Drosophila melanogaster Invertebrates early EARLY ncbigene_synonym lds 45894
Drosophila melanogaster Invertebrates SoxB1 SOXB1 ncbigene_synonym SoxN 44275
Drosophila melanogaster Invertebrates Dlx DLX ncbigene_synonym dx 31589
Drosophila melanogaster Invertebrates TFAP2 TFAP2 ncbigene_symbol TfAP-2 40398
Drosophila melanogaster Invertebrates Wnt WNT ncbigene_synonym Wnt5 32838
Drosophila melanogaster Invertebrates Wnt WNT ncbigene_synonym Wnt4 34007
Drosophila melanogaster Invertebrates Wnt WNT ncbigene_synonym wg 34009
Drosophila melanogaster Invertebrates Wnt WNT ncbigene_synonym Wnt2 35975
Drosophila melanogaster Invertebrates FGF FGF ncbigene_synonym bnl 42356
Xenopus laevis Vertebrates Msx1 MSX1 ncbigene_synonym msx1.S 399464
Xenopus laevis Vertebrates Msx1 MSX1 ncbigene_synonym msx1.L 100125666
Xenopus laevis Vertebrates Foxi1 FOXI1 ncbigene_synonym foxi1.L 380059
Xenopus laevis Vertebrates Zic1 ZIC1 ncbigene_synonym zic5.S 373661
Xenopus laevis Vertebrates Zic1 ZIC1 ncbigene_synonym zic1.S 399124
Xenopus laevis Vertebrates crest CREST ncbigene_synonym ss18l1.S 446990
Xenopus laevis Vertebrates crest CREST ncbigene_synonym ss18l1.L 108700928

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID
Cancer NA