Inactivation of Sag/Rbx2/Roc2 E3 Ubiquitin Ligase Triggers Senescence and Inhibits Kras-Induced Immortalization

Mechanism of Sag action in senescence and immortalization: Sag prevents senescence by promoting Jun-B ubiquitylation and degradation to block p16 expression, and Sag cooperates with KrasG12D to induce immortalization by maintaining active Kras activity and Mapk signaling pathway. Sag deletion induces senescence by causing Jun-B accumulation to increase p16 expression, and Sag deletion abrogates immortalization by inactivating Kras activity and Mapk signaling pathway (see text for details).
Inactivation of Sag/Rbx2/Roc2 E3 Ubiquitin Ligase Triggers Senescence and Inhibits Kras-Induced Immortalization
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Publication

Inactivation of Sag/Rbx2/Roc2 E3 Ubiquitin Ligase Triggers Senescence and Inhibits Kras-Induced Immortalization. (2015) Mingjia Tan, et al. Neoplasia. 2015 Jan;17(1):114-123. Figure: F8.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates Nedd8 NEDD8 ncbigene_symbol NEDD8 4738
Homo sapiens Primates Skp1 SKP1 ncbigene_symbol SKP1 6500
Homo sapiens Primates Kras KRAS ncbigene_symbol KRAS 3845
Homo sapiens Primates Kras KRAS ncbigene_synonym NRAS 4893
Homo sapiens Primates Fbxw7 FBXW7 ncbigene_symbol FBXW7 55294
Homo sapiens Primates GTP GTP ncbigene_synonym MTG1 92170
Homo sapiens Primates Raf RAF ncbigene_synonym ZHX2 22882
Homo sapiens Primates Raf RAF famplex_relations ARAF 369
Homo sapiens Primates Raf RAF famplex_relations BRAF 673
Homo sapiens Primates Raf RAF famplex_relations RAF1 5894
Homo sapiens Primates Mek MEK ncbigene_synonym MAP2K7 5609
Homo sapiens Primates Mek MEK famplex_relations MAP2K1 5604
Homo sapiens Primates Mek MEK famplex_relations MAP2K2 5605
Homo sapiens Primates p16 P16 ncbigene_synonym CDKN2A 1029
Homo sapiens Primates p16 P16 ncbigene_synonym H3P10 115482713
Homo sapiens Primates Erk ERK ncbigene_synonym EPHB2 2048
Homo sapiens Primates Erk ERK ncbigene_synonym MAPK1 5594
Homo sapiens Primates Erk ERK famplex_relations MAPK3 5595
Danio rerio Vertebrates Nedd8 NEDD8 ncbigene_symbol nedd8 368667
Danio rerio Vertebrates Skp1 SKP1 ncbigene_symbol skp1 393716
Danio rerio Vertebrates Kras KRAS ncbigene_symbol kras 445289
Danio rerio Vertebrates Fbxw7 FBXW7 ncbigene_symbol fbxw7 564991
Danio rerio Vertebrates p16 P16 ncbigene_synonym cdkn2a/b 100329528

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID
Cancer NA
Cardiomyopathy NA