mRNA decay pathways in the cytoplasm

mRNA decay pathways in the cytoplasm. There are two major cytoplasmic pathways to degrade mRNA that both start with the shortening of the poly(A) tail by one of the deadenylase complexes (Ccr4-Not or Pan2/3). The exosome can degrade the deadenylated mRNA in the 3′-to-5′ direction, and the scavenger decapping enzyme, Dcs1, degrades the remaining cap. The most prominent pathway involves decapping by Dcp1 and Dcp2 and subsequent degradation by the 5′-to-3′ exonuclease, Xrn1.

Publication

Coupling mRNA Synthesis and Decay. (2014) Katherine A. Braun, et al. Mol Cell Biol. 2014 Nov;34(22):4078-4087. Figure: F2. All organisms Homo sapiens Drosophila melanogaster

Disease mentions