CD147 plays an important role in a variety of cells and tissues regardless of health or disease

CD147 plays an important role in a variety of cells and tissues regardless of health or disease. (A) T cell-mediated immune response; (1) The regulatory role of CD147; (2) The “negative” regulatory role of CD147 as shown by CD147 knockdown (KD), leading to increased T cell proliferation; (3) CD147 regulates the ABCG2-driven transport of methotrexate; (B) Regulating the expression, dimerization and drug transporter function of ABCG2; (4) CD147–ABCG2 complex on the lymphoma cell membrane; (5) CD147 and ABCG2 mediate multidrug resistance in breast cancer (BC); (6) EGFR promotes multidrug resistance; (7) CD147, CD44 and EGFR signaling pathways cooperate to regulate invasiveness; (8) The phospholipase A2- and 5-lipoxygenase-catalyzed pathway and CD147 stimulate fibroblast MMP-2 release; (C) Tumor cell-Mφ interactions promote angiogenesis; (9) CD147 enhances the monocytic secretion of MMP-9 and VEGF, while inhibition of its expression decreases the induction of these two pro-angiogenic proteins; (10) KSHV activation of CD147 induces P13K/Akt- and MAPK-dependent secretion of VEGF; (D) The effects of CD147 on trophoblastic function; (11) Under progesterone-rich conditions, CD147 regulates MMPs and PLGF during gestation; (E) Regulating the proliferation, anoikis, migration and metastasis of HCCs; (12) Caveolin-1 promotes HCC invasion by up-regulating the glycosylation of CD147; (13) CD147 mediates resistance to anoikis in HCC cells by activating the PI3K/Akt pathway; (14) The key role of GnT–IVa in the migration and metastasis of HCCs involves alteration of the antennary oligosaccharide structures on glycosylated CD147; (F) Regulating the metastasis and chemoresistance of PCa cells; (15) CD147 expression is mediated by the PI3K and MAPK pathways; (16) CD147 KD decreases MCT4 and multi-drug resistance protein-2(Mdrp2) expression and reduces the invasive potential and proliferation of PCa while enhancing docetaxel sensitivity; (17) CD147 KD down-regulates p-Akt and p-Erk, the main signal modulators associated with cell growth and survival; (G) Regulating the migration and metastasis of GCs; (18) The ERK1/2 signaling pathway is involved in CD147-mediated proliferation and invasion of gastric cancer cells; (19) Extracellular Cyp-A stimulates ERK1/2 phosphorylation.

Publication

The Biological Function and Clinical Utilization of CD147 in Human Diseases: A Review of the Current Scientific Literature. (2014) Lijuan Xiong, et al. Int J Mol Sci. 2014 Oct;15(10):17411-17441. Figure: F2. All organisms Rattus norvegicus Bos taurus Homo sapiens Gallus gallus Oryctolagus cuniculus Mus musculus Drosophila melanogaster

Disease mentions