Dicarbonyl stress and RAGE signaling

Dicarbonyl stress and RAGE signaling

Dicarbonyl stress and RAGE signaling. Increased flux through the glycolytic pathway increases MG formation. Reduced GLO1 activity in this setting decreases the degradation of MG, resulting in excess formation of MG-H1. MG-H1 activates RAGE. RAGE activation leads to increased ROS production that subsequently activates the transcription factor, nuclear factor-κΒ (NF-κB), to stimulate the expression of adhesion molecules and chemokines. P, phosphorylation.

Publication

Dicarbonyl Stress and Atherosclerosis: Is It All RAGE?. (2014) Ranganath Muniyappa, et al. Diabetes. 2014 Nov;63(11):3587-3589. Figure: F1.

Gene mentions

Organism	Group	Word	Match	Source	NCBI Symbol	NCBI ID
Homo sapiens	Primates	RAGE	RAGE	ncbigene_synonym	AGER	177
Homo sapiens	Primates	RAGE	RAGE	ncbigene_synonym	MOK	5891
Homo sapiens	Primates	NADPH	NADPH	ncbigene_synonym	DECR1	1666
Homo sapiens	Primates	NF-KB	NF-KB	ncbigene_synonym	NFKB1	4790
Homo sapiens	Primates	GLO1	GLO1	ncbigene_symbol	GLO1	2739
Homo sapiens	Primates	ICAM-1	ICAM1	ncbigene_symbol	ICAM1	3383
Homo sapiens	Primates	VCAM-1,	VCAM1	ncbigene_symbol	VCAM1	7412
Homo sapiens	Primates	MCP-1	MCP-1	ncbigene_synonym	CCL2	6347
Homo sapiens	Primates	GLO2	GLO2	ncbigene_synonym	HAGH	3029
Rattus norvegicus	Rodents	RAGE	RAGE	ncbigene_synonym	Ager	81722
Rattus norvegicus	Rodents	RAGE	RAGE	ncbigene_synonym	Mok	362787
Rattus norvegicus	Rodents	NF-KB	NF-KB	ncbigene_synonym	Nfkb1	81736
Rattus norvegicus	Rodents	GLO1	GLO1	ncbigene_symbol	Glo1	294320
Rattus norvegicus	Rodents	ICAM-1	ICAM1	ncbigene_symbol	Icam1	25464
Rattus norvegicus	Rodents	VCAM-1,	VCAM1	ncbigene_symbol	Vcam1	25361
Rattus norvegicus	Rodents	MCP-1	MCP-1	ncbigene_synonym	Ccl2	24770
Rattus norvegicus	Rodents	GLO2	GLO2	ncbigene_synonym	Hagh	24439
Mus musculus	Rodents	RAGE	RAGE	ncbigene_synonym	Ager	11596
Mus musculus	Rodents	RAGE	RAGE	ncbigene_synonym	Mok	26448
Mus musculus	Rodents	NADPH	NADPH	ncbigene_synonym	Decr1	67460
Mus musculus	Rodents	NF-KB	NF-KB	ncbigene_synonym	Nfkb1	18033
Mus musculus	Rodents	GLO1	GLO1	ncbigene_symbol	Glo1	109801
Mus musculus	Rodents	ICAM-1	ICAM-1	ncbigene_synonym	Icam1	15894
Mus musculus	Rodents	VCAM-1,	VCAM-1	ncbigene_synonym	Vcam1	22329
Mus musculus	Rodents	MCP-1	MCP-1	ncbigene_synonym	Mcpt1	17224
Mus musculus	Rodents	MCP-1	MCP-1	ncbigene_synonym	Ccl2	20296
Mus musculus	Rodents	GLO2	GLO2	ncbigene_synonym	Hagh	14651
Saccharomyces cerevisiae S288C	Plants and Fungi	GLO1	GLO1	ncbigene_symbol	GLO1	855009
Saccharomyces cerevisiae S288C	Plants and Fungi	MCP-1	MCP1	ncbigene_symbol	MCP1	854403
Saccharomyces cerevisiae S288C	Plants and Fungi	GLO2	GLO2	ncbigene_symbol	GLO2	851865
Caenorhabditis elegans	Invertebrates	GLO1	GLO1	ncbigene_symbol	glo-1	3565633
Caenorhabditis elegans	Invertebrates	MCP-1	MCP-1	ncbigene_symbol	mcp-1	178982
Caenorhabditis elegans	Invertebrates	GLO2	GLO2	ncbigene_symbol	glo-2	186447

Chemical mentions

Word	Match	MeSH	Name	ChEBI
dihydroxyacetone	Dihydroxyacetone	mesh:D004098	dihydroxyacetone	chebi:16016
Fructose	Fructose	mesh:D005632	fructose	chebi:28757
Glucose	Glucose	mesh:D005947	D-glucopyranose	chebi:4167
Glyceraldehyde-3-P	Glyceraldehyde	mesh:D005985	glyceraldehyde	chebi:5445
Methylglyoxal	Pyruvaldehyde	mesh:D011765	methylglyoxal	chebi:17158
D-lactate	NA	mesh:D019344

Disease mentions

Word	Match	MeSH	Name	DOID