XBP1 is the Missing Link between the UPR and O-GlcNAcylation
(A) XBP1 is the Missing Link between the UPR and O-GlcNAcylation. The contributions made by Wang et al are shown in blue. (B) Proteins are glycosylated in different cell compartments. (C) A key substrate for O-GlcNAcylation, which is used by the enzyme OGT (O-GlcNAc transferase), is UDP-GlcNAc (uridine diphosphate N-acetyl glucosamine). (D) UDP-GlcNAc is generated by the hexose biosynthetic pathway (HBP). O-GlcNAc groups can be removed from proteins by OGA (O-GlcNAcase). The contributions made by Wang et al are shown in blue.
Publication
Finding the Missing Link between the Unfolded Protein Response and O-GlcNAcylation in the Heart. (2014) Christopher C. Glembotski. Circ Res. 2014 Aug 29;115(6):546-548. Figure: F1.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Drosophila melanogaster | Invertebrates | Link | LINK | ncbigene_symbol | link | 36509 |
| Drosophila melanogaster | Invertebrates | GFAT1 | GFAT1 | ncbigene_symbol | Gfat1 | 3354921 |
| Drosophila melanogaster | Invertebrates | step | STEP | ncbigene_symbol | step | 35425 |
| Drosophila melanogaster | Invertebrates | XBP1 | XBP1 | ncbigene_symbol | Xbp1 | 44226 |
| Drosophila melanogaster | Invertebrates | OGT | OGT | ncbigene_synonym | sxc | 35486 |
| Homo sapiens | Primates | (HBP) | HBP | ncbigene_synonym | AZU1 | 566 |
| Homo sapiens | Primates | (HBP) | HBP | ncbigene_synonym | HDLBP | 3069 |
| Homo sapiens | Primates | (HBP) | HBP | ncbigene_synonym | SLBP | 7884 |
| Homo sapiens | Primates | (HBP) | HBP | ncbigene_synonym | STAM2 | 10254 |
| Homo sapiens | Primates | (HBP) | HBP | ncbigene_synonym | HEBP1 | 50865 |
| Homo sapiens | Primates | GFAT1 | GFAT1 | ncbigene_synonym | GFPT1 | 2673 |
| Homo sapiens | Primates | step | STEP | ncbigene_synonym | PTPN5 | 84867 |
| Homo sapiens | Primates | XBP1 | XBP1 | ncbigene_symbol | XBP1 | 7494 |
| Homo sapiens | Primates | XBP1 | XBP1 | ncbigene_synonym | XBP1P1 | 7495 |
| Homo sapiens | Primates | simple | SIMPLE | ncbigene_synonym | LITAF | 9516 |
| Homo sapiens | Primates | OGT | OGT | ncbigene_symbol | OGT | 8473 |
| Homo sapiens | Primates | OGT | OGT | famplex_relations | EOGT | 285203 |
| Homo sapiens | Primates | OGT | OGT | famplex_relations | POMGNT1 | 55624 |
| Homo sapiens | Primates | OGT | OGT | famplex_relations | POMGNT2 | 84892 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| Asn | Asparagine | mesh:D001216 | L-asparagine | chebi:17196 |
| fructose-6-PO | Fructose | mesh:D005632 | fructose | chebi:28757 |
| glucosamine | Glucosamine | mesh:D005944 | glucosamine | chebi:5417 |
| glucose | Glucose | mesh:D005947 | D-glucopyranose | chebi:4167 |
| hexosamine | Hexosamines | mesh:D006595 | hexosamine | chebi:24586 |
| monosaccharide | Monosaccharides | mesh:D009005 | monosaccharide | chebi:35381 |
| Ser | Serine | mesh:D012694 | L-serine | chebi:17115 |
| Thr | Threonine | mesh:D013912 | L-threonine | chebi:16857 |
| UDP | Uridine Diphosphate | mesh:D014530 | UDP | chebi:17659 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|