Activation of the ATR-signaling pathway during G1/G0 or G2-M phases of the cell cycle

Model of activation of the ATR-signaling pathway during G1/G0 or G2-M phases of the cell cycle. When DNA is damaged by UV or a UV-mimetic agent, the core excision repair factors (RPA, XPA, XPC, TFIIH, XPG, XPF-ERCC1) excise a ∼30 nt oligomer containing the damage. (Note that XPC, after playing an essential role in damage recognition, dissociates from the repair complex prior to the dual incisions (1) (18), and hence it is not shown in the incision complex.) The resulting gap is either filled in by polymerases or the gap is enlarged by EXO1. The enlarged ssDNA gap is coated with RPA, which recruits ATR-ATRIP, TopBP1, and substrates including p53. The close proximity of the ATR kinase with its activator, TopBP1, and substrate, p53, results in phosphorylation and checkpoint activation.
Activation of the ATR-signaling pathway during G1/G0 or G2-M phases of the cell cycle

Publication

Coupling of Human DNA Excision Repair and the DNA Damage Checkpoint in a Defined in Vitro System. (2014) Laura A. Lindsey-Boltz, et al. J Biol Chem. 2014 Feb 21;289(8):5074-5082. Figure: F7.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates Lig LIG ncbigene_synonym UBE2K 3093
Homo sapiens Primates Pol POL ncbigene_synonym ERVW-4 100616496
Homo sapiens Primates PCNA PCNA ncbigene_symbol PCNA 5111
Homo sapiens Primates XPC XPC ncbigene_symbol XPC 7508
Homo sapiens Primates TFIIH TFIIH ncbigene_synonym ERCC2 2068
Homo sapiens Primates TFIIH TFIIH ncbigene_synonym ERCC3 2071
Homo sapiens Primates TFIIH TFIIH ncbigene_synonym GTF2H1 2965
Homo sapiens Primates TFIIH TFIIH ncbigene_synonym GTF2H2 2966
Homo sapiens Primates TFIIH TFIIH ncbigene_synonym GTF2H3 2967
Homo sapiens Primates TFIIH TFIIH ncbigene_synonym GTF2H4 2968
Homo sapiens Primates TFIIH TFIIH ncbigene_synonym GTF2H5 404672
Homo sapiens Primates XPA XPA ncbigene_symbol XPA 7507
Homo sapiens Primates RPA RPA ncbigene_synonym RPA1 6117
Homo sapiens Primates RPA RPA famplex_relations RPA2 6118
Homo sapiens Primates RPA RPA famplex_relations RPA3 6119
Homo sapiens Primates Gap GAP ncbigene_synonym RASA1 5921
Homo sapiens Primates Gap GAP ncbigene_synonym RGS6 9628
Homo sapiens Primates HHH HHH ncbigene_synonym SLC25A15 10166
Homo sapiens Primates ATR ATR ncbigene_symbol ATR 545
Homo sapiens Primates ATR ATR ncbigene_synonym ANTXR1 84168
Homo sapiens Primates ATR ATR ncbigene_synonym MMAB 326625
Homo sapiens Primates ATR ATR ncbigene_synonym SERPINA2 390502
Homo sapiens Primates ATRIP ATRIP ncbigene_symbol ATRIP 84126
Homo sapiens Primates p53 P53 ncbigene_synonym TP53 7157
Homo sapiens Primates p53 P53 famplex_relations TP63 8626
Homo sapiens Primates p53 P53 famplex_relations TP73 7161
Homo sapiens Primates TopBP1 TOPBP1 ncbigene_symbol TOPBP1 11073
Mus musculus Rodents Lig LIG ncbigene_synonym Ube2k 53323
Mus musculus Rodents Pol POL ncbigene_synonym Mela 17276
Mus musculus Rodents Pol POL ncbigene_synonym Gm42368 105247234
Mus musculus Rodents PCNA PCNA ncbigene_symbol Pcna 18538
Mus musculus Rodents XPC XPC ncbigene_symbol Xpc 22591
Mus musculus Rodents TFIIH TFIIH ncbigene_synonym Gtf2h3 209357
Mus musculus Rodents XPA XPA ncbigene_symbol Xpa 22590
Mus musculus Rodents RPA RPA ncbigene_synonym Rpa1 68275
Mus musculus Rodents Gap GAP ncbigene_synonym Rap1gap 110351
Mus musculus Rodents Gap GAP ncbigene_synonym Rasa1 218397
Mus musculus Rodents ATR ATR ncbigene_symbol Atr 245000
Mus musculus Rodents ATR ATR ncbigene_synonym Mmab 77697
Mus musculus Rodents ATRIP ATRIP ncbigene_symbol Atrip 235610
Mus musculus Rodents p53 P53 ncbigene_synonym Trp53 22059
Mus musculus Rodents TopBP1 TOPBP1 ncbigene_symbol Topbp1 235559
Danio rerio Vertebrates PCNA PCNA ncbigene_symbol pcna 30678
Danio rerio Vertebrates XPC XPC ncbigene_symbol xpc 541386
Danio rerio Vertebrates XPA XPA ncbigene_symbol xpa 393443
Danio rerio Vertebrates RPA RPA ncbigene_synonym rpa2 65226
Danio rerio Vertebrates Gap GAP ncbigene_synonym gap43 30608
Danio rerio Vertebrates ATR ATR ncbigene_symbol atr 567770
Danio rerio Vertebrates ATRIP ATRIP ncbigene_symbol atrip 558534
Danio rerio Vertebrates p53 P53 ncbigene_synonym tp53 30590
Danio rerio Vertebrates TopBP1 TOPBP1 ncbigene_symbol topbp1 407679

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID