Activation of the ATR-signaling pathway during G1/G0 or G2-M phases of the cell cycle
Model of activation of the ATR-signaling pathway during G1/G0 or G2-M phases of the cell cycle. When DNA is damaged by UV or a UV-mimetic agent, the core excision repair factors (RPA, XPA, XPC, TFIIH, XPG, XPF-ERCC1) excise a ∼30 nt oligomer containing the damage. (Note that XPC, after playing an essential role in damage recognition, dissociates from the repair complex prior to the dual incisions (1) (18), and hence it is not shown in the incision complex.) The resulting gap is either filled in by polymerases or the gap is enlarged by EXO1. The enlarged ssDNA gap is coated with RPA, which recruits ATR-ATRIP, TopBP1, and substrates including p53. The close proximity of the ATR kinase with its activator, TopBP1, and substrate, p53, results in phosphorylation and checkpoint activation.

Publication
Coupling of Human DNA Excision Repair and the DNA Damage Checkpoint in a Defined in Vitro System. (2014) Laura A. Lindsey-Boltz, et al. J Biol Chem. 2014 Feb 21;289(8):5074-5082. Figure: F7.Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
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Homo sapiens | Primates | Lig | LIG | ncbigene_synonym | UBE2K | 3093 |
Homo sapiens | Primates | Pol | POL | ncbigene_synonym | ERVW-4 | 100616496 |
Homo sapiens | Primates | PCNA | PCNA | ncbigene_symbol | PCNA | 5111 |
Homo sapiens | Primates | XPC | XPC | ncbigene_symbol | XPC | 7508 |
Homo sapiens | Primates | TFIIH | TFIIH | ncbigene_synonym | ERCC2 | 2068 |
Homo sapiens | Primates | TFIIH | TFIIH | ncbigene_synonym | ERCC3 | 2071 |
Homo sapiens | Primates | TFIIH | TFIIH | ncbigene_synonym | GTF2H1 | 2965 |
Homo sapiens | Primates | TFIIH | TFIIH | ncbigene_synonym | GTF2H2 | 2966 |
Homo sapiens | Primates | TFIIH | TFIIH | ncbigene_synonym | GTF2H3 | 2967 |
Homo sapiens | Primates | TFIIH | TFIIH | ncbigene_synonym | GTF2H4 | 2968 |
Homo sapiens | Primates | TFIIH | TFIIH | ncbigene_synonym | GTF2H5 | 404672 |
Homo sapiens | Primates | XPA | XPA | ncbigene_symbol | XPA | 7507 |
Homo sapiens | Primates | RPA | RPA | ncbigene_synonym | RPA1 | 6117 |
Homo sapiens | Primates | RPA | RPA | famplex_relations | RPA2 | 6118 |
Homo sapiens | Primates | RPA | RPA | famplex_relations | RPA3 | 6119 |
Homo sapiens | Primates | Gap | GAP | ncbigene_synonym | RASA1 | 5921 |
Homo sapiens | Primates | Gap | GAP | ncbigene_synonym | RGS6 | 9628 |
Homo sapiens | Primates | HHH | HHH | ncbigene_synonym | SLC25A15 | 10166 |
Homo sapiens | Primates | ATR | ATR | ncbigene_symbol | ATR | 545 |
Homo sapiens | Primates | ATR | ATR | ncbigene_synonym | ANTXR1 | 84168 |
Homo sapiens | Primates | ATR | ATR | ncbigene_synonym | MMAB | 326625 |
Homo sapiens | Primates | ATR | ATR | ncbigene_synonym | SERPINA2 | 390502 |
Homo sapiens | Primates | ATRIP | ATRIP | ncbigene_symbol | ATRIP | 84126 |
Homo sapiens | Primates | p53 | P53 | ncbigene_synonym | TP53 | 7157 |
Homo sapiens | Primates | p53 | P53 | famplex_relations | TP63 | 8626 |
Homo sapiens | Primates | p53 | P53 | famplex_relations | TP73 | 7161 |
Homo sapiens | Primates | TopBP1 | TOPBP1 | ncbigene_symbol | TOPBP1 | 11073 |
Mus musculus | Rodents | Lig | LIG | ncbigene_synonym | Ube2k | 53323 |
Mus musculus | Rodents | Pol | POL | ncbigene_synonym | Mela | 17276 |
Mus musculus | Rodents | Pol | POL | ncbigene_synonym | Gm42368 | 105247234 |
Mus musculus | Rodents | PCNA | PCNA | ncbigene_symbol | Pcna | 18538 |
Mus musculus | Rodents | XPC | XPC | ncbigene_symbol | Xpc | 22591 |
Mus musculus | Rodents | TFIIH | TFIIH | ncbigene_synonym | Gtf2h3 | 209357 |
Mus musculus | Rodents | XPA | XPA | ncbigene_symbol | Xpa | 22590 |
Mus musculus | Rodents | RPA | RPA | ncbigene_synonym | Rpa1 | 68275 |
Mus musculus | Rodents | Gap | GAP | ncbigene_synonym | Rap1gap | 110351 |
Mus musculus | Rodents | Gap | GAP | ncbigene_synonym | Rasa1 | 218397 |
Mus musculus | Rodents | ATR | ATR | ncbigene_symbol | Atr | 245000 |
Mus musculus | Rodents | ATR | ATR | ncbigene_synonym | Mmab | 77697 |
Mus musculus | Rodents | ATRIP | ATRIP | ncbigene_symbol | Atrip | 235610 |
Mus musculus | Rodents | p53 | P53 | ncbigene_synonym | Trp53 | 22059 |
Mus musculus | Rodents | TopBP1 | TOPBP1 | ncbigene_symbol | Topbp1 | 235559 |
Danio rerio | Vertebrates | PCNA | PCNA | ncbigene_symbol | pcna | 30678 |
Danio rerio | Vertebrates | XPC | XPC | ncbigene_symbol | xpc | 541386 |
Danio rerio | Vertebrates | XPA | XPA | ncbigene_symbol | xpa | 393443 |
Danio rerio | Vertebrates | RPA | RPA | ncbigene_synonym | rpa2 | 65226 |
Danio rerio | Vertebrates | Gap | GAP | ncbigene_synonym | gap43 | 30608 |
Danio rerio | Vertebrates | ATR | ATR | ncbigene_symbol | atr | 567770 |
Danio rerio | Vertebrates | ATRIP | ATRIP | ncbigene_symbol | atrip | 558534 |
Danio rerio | Vertebrates | p53 | P53 | ncbigene_synonym | tp53 | 30590 |
Danio rerio | Vertebrates | TopBP1 | TOPBP1 | ncbigene_symbol | topbp1 | 407679 |
Word | Match | MeSH | Name | ChEBI |
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Disease mentions
Word | Match | MeSH | Name | DOID |
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