WNT3 Inhibits Cerebellar Granule Neuron Progenitor Proliferation and Medulloblastoma Formation via MAPK Activation

In Hedgehog (Hh) signaling, Sonic Hedgehog (SHH) binds Patched (PTCH) receptor, relieving its inhibition of Smoothened (SMO), and stimulating GCP proliferation. In WNT3 signaling, WNT3 binds an undefined receptor to activate MAPK signaling via a non canonical WNT pathway to promote GCP differentiation, whereas other WNTs bind Frizzled (FRZ) receptor to activate the canonical β-catenin pathway and stimulate proliferation. We propose a model whereby regulation of MAPK activity by WNT3 signaling alters the balance between proliferation and differentiation in GCPs, decreasing proliferation and increasing differentiation.
WNT3 Inhibits Cerebellar Granule Neuron Progenitor Proliferation and Medulloblastoma Formation via MAPK Activation
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WNT3 Inhibits Cerebellar Granule Neuron Progenitor Proliferation and Medulloblastoma Formation via MAPK Activation. (2013) Sandrine L. Anne, et al. PLoS One. 2013;8(11):e81769. Figure: F9.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates WNT3 WNT3 ncbigene_symbol WNT3 7473
Homo sapiens Primates SHH SHH ncbigene_symbol SHH 6469
Homo sapiens Primates WNT WNT famplex_relations WNT1 7471
Homo sapiens Primates WNT WNT famplex_relations WNT2 7472
Homo sapiens Primates WNT WNT famplex_relations WNT2B 7482
Homo sapiens Primates WNT WNT famplex_relations WNT3A 89780
Homo sapiens Primates WNT WNT famplex_relations WNT4 54361
Homo sapiens Primates WNT WNT famplex_relations WNT6 7475
Homo sapiens Primates WNT WNT famplex_relations WNT7A 7476
Homo sapiens Primates WNT WNT famplex_relations WNT7B 7477
Homo sapiens Primates WNT WNT famplex_relations WNT8A 7478
Homo sapiens Primates WNT WNT famplex_relations WNT8B 7479
Homo sapiens Primates WNT WNT famplex_relations WNT9A 7483
Homo sapiens Primates WNT WNT famplex_relations WNT9B 7484
Homo sapiens Primates WNT WNT famplex_relations WNT10A 80326
Homo sapiens Primates WNT WNT famplex_relations WNT10B 7480
Homo sapiens Primates WNT WNT famplex_relations WNT11 7481
Homo sapiens Primates WNT WNT famplex_relations WNT16 51384
Homo sapiens Primates WNT WNT famplex_relations WNT5A 7474
Homo sapiens Primates WNT WNT famplex_relations WNT5B 81029
Homo sapiens Primates \PTCH1 PTCH1 ncbigene_symbol PTCH1 5727
Homo sapiens Primates SMO SMO ncbigene_symbol SMO 6608
Homo sapiens Primates SMO SMO ncbigene_synonym SMOX 54498
Homo sapiens Primates AAA AAA ncbigene_synonym APP 351
Homo sapiens Primates AAA AAA ncbigene_synonym AAAS 8086
Homo sapiens Primates AAA AAA ncbigene_synonym AAA1 100329167
Homo sapiens Primates LRP5/6 LRP6 ncbigene_symbol LRP6 4040
Homo sapiens Primates LRP5/6 LRP5 ncbigene_symbol LRP5 4041
Homo sapiens Primates B-Catenin CTNNB1 ncbigene_symbol CTNNB1 1499
Homo sapiens Primates MAPK MAPK famplex_relations MAPK1 5594
Homo sapiens Primates MAPK MAPK famplex_relations MAPK3 5595
Homo sapiens Primates MAPK MAPK famplex_relations MAPK11 5600
Homo sapiens Primates MAPK MAPK famplex_relations MAPK12 6300
Homo sapiens Primates MAPK MAPK famplex_relations MAPK13 5603
Homo sapiens Primates MAPK MAPK famplex_relations MAPK14 1432
Homo sapiens Primates MAPK MAPK famplex_relations MAPK8 5599
Homo sapiens Primates MAPK MAPK famplex_relations MAPK9 5601
Homo sapiens Primates MAPK MAPK famplex_relations MAPK10 5602
Mus musculus Rodents WNT3 WNT3 ncbigene_symbol Wnt3 22415
Mus musculus Rodents SHH SHH ncbigene_symbol Shh 20423
Mus musculus Rodents \PTCH1 PTCH1 ncbigene_symbol Ptch1 19206
Mus musculus Rodents SMO SMO ncbigene_symbol Smo 319757
Mus musculus Rodents SMO SMO ncbigene_synonym Smox 228608
Mus musculus Rodents AAA AAA ncbigene_synonym Aaas 223921
Mus musculus Rodents LRP5/6 LRP6 ncbigene_symbol Lrp6 16974
Mus musculus Rodents LRP5/6 LRP5 ncbigene_symbol Lrp5 16973
Mus musculus Rodents B-Catenin CTNNB1 ncbigene_symbol Ctnnb1 12387
Capra hircus Mammals WNT3 WNT3 ncbigene_symbol WNT3 102169703
Capra hircus Mammals SHH SHH ncbigene_symbol SHH 102170201
Capra hircus Mammals \PTCH1 PTCH1 ncbigene_symbol PTCH1 102187048
Capra hircus Mammals SMO SMO ncbigene_symbol SMO 102171572
Capra hircus Mammals LRP5/6 LRP6 ncbigene_symbol LRP6 102177417
Capra hircus Mammals LRP5/6 LRP5 ncbigene_symbol LRP5 106503755
Capra hircus Mammals B-Catenin CTNNB1 ncbigene_symbol CTNNB1 102191742
Capra hircus Mammals B-Catenin CTNNB1 ncbigene_synonym CTNND1 102183255
Gallus gallus Vertebrates WNT3 WNT3 ncbigene_symbol WNT3 374142
Gallus gallus Vertebrates SHH SHH ncbigene_symbol SHH 395615
Gallus gallus Vertebrates \PTCH1 PTCH1 ncbigene_symbol PTCH1 395806
Gallus gallus Vertebrates SMO SMO ncbigene_symbol SMO 395949
Gallus gallus Vertebrates LRP5/6 LRP6 ncbigene_symbol LRP6 419097
Gallus gallus Vertebrates LRP5/6 LRP5 ncbigene_symbol LRP5 423114
Gallus gallus Vertebrates B-Catenin CTNNB1 ncbigene_symbol CTNNB1 395964
Oryctolagus cuniculus Mammals WNT3 WNT3 ncbigene_symbol WNT3 100009033
Oryctolagus cuniculus Mammals SHH SHH ncbigene_symbol SHH 100352774
Oryctolagus cuniculus Mammals \PTCH1 PTCH1 ncbigene_symbol PTCH1 100345046
Oryctolagus cuniculus Mammals SMO SMO ncbigene_symbol SMO 100352661
Oryctolagus cuniculus Mammals LRP5/6 LRP6 ncbigene_symbol LRP6 100352000
Oryctolagus cuniculus Mammals LRP5/6 LRP5 ncbigene_symbol LRP5 100009566
Oryctolagus cuniculus Mammals B-Catenin CTNNB1 ncbigene_symbol CTNNB1 100125985
Bos taurus Mammals WNT3 WNT3 ncbigene_symbol WNT3 540753
Bos taurus Mammals SHH SHH ncbigene_symbol SHH 286821
Bos taurus Mammals \PTCH1 PTCH1 ncbigene_symbol PTCH1 520994
Bos taurus Mammals SMO SMO ncbigene_symbol SMO 539308
Bos taurus Mammals LRP5/6 LRP6 ncbigene_symbol LRP6 536328
Bos taurus Mammals LRP5/6 LRP5 ncbigene_symbol LRP5 534450
Bos taurus Mammals B-Catenin CTNNB1 ncbigene_symbol CTNNB1 539003
Drosophila melanogaster Invertebrates WNT3 WNT3 ncbigene_synonym Wnt5 32838
Drosophila melanogaster Invertebrates WNT WNT ncbigene_synonym Wnt4 34007
Drosophila melanogaster Invertebrates WNT WNT ncbigene_synonym wg 34009
Drosophila melanogaster Invertebrates WNT WNT ncbigene_synonym Wnt2 35975
Drosophila melanogaster Invertebrates FRZ FRZ ncbigene_synonym fz 45307
Drosophila melanogaster Invertebrates SMO SMO ncbigene_symbol smo 33196
Drosophila melanogaster Invertebrates SMO SMO ncbigene_synonym sm 37254
Drosophila melanogaster Invertebrates AAA AAA ncbigene_synonym tRNA:Lys-TTT-1-1 3772008
Drosophila melanogaster Invertebrates AAA AAA ncbigene_synonym tRNA:Lys-TTT-2-4 3772033
Drosophila melanogaster Invertebrates AAA AAA ncbigene_synonym tRNA:Lys-TTT-2-1 3772125
Drosophila melanogaster Invertebrates AAA AAA ncbigene_synonym tRNA:Lys-TTT-2-2 3772333
Drosophila melanogaster Invertebrates AAA AAA ncbigene_synonym tRNA:Lys-TTT-2-5 3772413
Drosophila melanogaster Invertebrates AAA AAA ncbigene_synonym tRNA:Lys-TTT-2-3 3772688
Drosophila melanogaster Invertebrates LRP5/6 LRP5/6 ncbigene_synonym arr 44279
Drosophila melanogaster Invertebrates B-Catenin B-CATENIN ncbigene_synonym arm 31151
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym MKP-4 32963
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym p38b 34780
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym rl 3354888
Xenopus laevis Vertebrates WNT3 WNT3 ncbigene_synonym wnt3.L 108700866
Xenopus laevis Vertebrates WNT3 WNT3 ncbigene_synonym wnt3a.L 108718689
Xenopus laevis Vertebrates SHH SHH ncbigene_synonym shh.L 398047
Xenopus laevis Vertebrates \PTCH1 PTCH1 ncbigene_synonym ptch1.S 398215
Xenopus laevis Vertebrates SMO SMO ncbigene_synonym smo.S 398216
Xenopus laevis Vertebrates SMO SMO ncbigene_synonym smo.L 100190780
Xenopus laevis Vertebrates LRP5/6 LRP6 ncbigene_synonym lrp6.L 373826
Xenopus laevis Vertebrates LRP5/6 LRP6 ncbigene_synonym lrp6.S 378494
Xenopus laevis Vertebrates LRP5/6 LRP5 ncbigene_synonym lrp5.L 373722
Xenopus laevis Vertebrates B-Catenin B-CATENIN ncbigene_synonym ctnnb1.S 380441
Xenopus laevis Vertebrates B-Catenin B-CATENIN ncbigene_synonym ctnnb1.L 399274
Xenopus laevis Vertebrates MAPK MAPK ncbigene_synonym mapk1.L 397785
Xenopus laevis Vertebrates MAPK MAPK ncbigene_synonym mapk1.S 398985

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID