Rho GTPase signaling pathway

Schematic illustration of Rho GTPase signaling pathway. A. Receptor dependent and independent signaling through Rho GTPase pathway leading to actin reorganization. Numbered arrows indicate where the inhibitor targets are in the Rho GTPase signaling cascade: 1, Y27632, fasudil, and H-1152; 2, LM11A31; 3, statins; 4, NSC23766; 5, CCG-1423. B. Regulation of Rho GTPase activation and inactivation through Rho-GEFs, Rho-GAPs, and RhoGDIs.
Rho GTPase signaling pathway
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Publication

Signaling Through Rho GTPase Pathway as Viable Drug Target. () Qun Lu, et al. Curr Med Chem. ;16(11):1355-1365. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Drosophila melanogaster Invertebrates lon LON ncbigene_symbol Lon 40138
Drosophila melanogaster Invertebrates lon LON ncbigene_synonym schlank 50392
Drosophila melanogaster Invertebrates Integrins INTEGRIN ncbigene_synonym scb 36692
Drosophila melanogaster Invertebrates Rho RHO ncbigene_symbol rho 38168
Drosophila melanogaster Invertebrates Rho RHO ncbigene_synonym Bx 32846
Drosophila melanogaster Invertebrates Rho RHO ncbigene_synonym Rho1 36775
Drosophila melanogaster Invertebrates Rho RHO ncbigene_synonym Lcp65Ab1 48382
Drosophila melanogaster Invertebrates GDI GDI ncbigene_symbol Gdi 34264
Drosophila melanogaster Invertebrates GAP GAP ncbigene_synonym Gapdh2 32545
Drosophila melanogaster Invertebrates GAP GAP ncbigene_synonym CdGAPr 35267
Drosophila melanogaster Invertebrates GAP GAP ncbigene_synonym Gapdh1 35728
Drosophila melanogaster Invertebrates GAP GAP ncbigene_synonym RasGAP1 39158
Drosophila melanogaster Invertebrates GAP GAP ncbigene_synonym ArfGAP1 39417
Drosophila melanogaster Invertebrates PKN PKN ncbigene_symbol Pkn 35950
Drosophila melanogaster Invertebrates PKN PKN ncbigene_synonym meng 33948
Drosophila melanogaster Invertebrates PKN PKN ncbigene_synonym CG4945 36850
Drosophila melanogaster Invertebrates ROCK ROCK ncbigene_synonym Rok 43916
Drosophila melanogaster Invertebrates Pi PI ncbigene_symbol pi 5656965
Drosophila melanogaster Invertebrates GEF: GEF ncbigene_synonym PDZ-GEF 33881
Drosophila melanogaster Invertebrates GEF: GEF ncbigene_synonym garz 36337
Drosophila melanogaster Invertebrates GEF: GEF ncbigene_synonym RhoGEF64C 38578
Drosophila melanogaster Invertebrates GEF: GEF ncbigene_synonym pbl 38879
Drosophila melanogaster Invertebrates Actin ACTIN ncbigene_synonym Act5C 31521
Drosophila melanogaster Invertebrates Actin ACTIN ncbigene_synonym Act42A 35526
Drosophila melanogaster Invertebrates Actin ACTIN ncbigene_synonym Act57B 37368
Drosophila melanogaster Invertebrates Actin ACTIN ncbigene_synonym Act79B 40444
Drosophila melanogaster Invertebrates Actin ACTIN ncbigene_synonym Act88F 41885
Drosophila melanogaster Invertebrates Actin ACTIN ncbigene_synonym Act87E 48632
Homo sapiens Primates GPC GPC ncbigene_synonym GYPC 2995
Homo sapiens Primates lon LON ncbigene_synonym LONP1 9361
Homo sapiens Primates Integrins INTEGRINS famplex_relations ITGA1 3672
Homo sapiens Primates Integrins INTEGRINS famplex_relations ITGA10 8515
Homo sapiens Primates Integrins INTEGRINS famplex_relations ITGA11 22801
Homo sapiens Primates Integrins INTEGRINS famplex_relations ITGA2 3673
Homo sapiens Primates Integrins INTEGRINS famplex_relations ITGA2B 3674
Homo sapiens Primates Integrins INTEGRINS famplex_relations ITGA3 3675
Homo sapiens Primates Integrins INTEGRINS famplex_relations ITGA4 3676
Homo sapiens Primates Integrins INTEGRINS famplex_relations ITGA5 3678
Homo sapiens Primates Integrins INTEGRINS famplex_relations ITGA6 3655
Homo sapiens Primates Integrins INTEGRINS famplex_relations ITGA7 3679
Homo sapiens Primates Integrins INTEGRINS famplex_relations ITGA8 8516
Homo sapiens Primates Integrins INTEGRINS famplex_relations ITGA9 3680
Homo sapiens Primates Integrins INTEGRINS famplex_relations ITGAD 3681
Homo sapiens Primates Integrins INTEGRINS famplex_relations ITGAE 3682
Homo sapiens Primates Integrins INTEGRINS famplex_relations ITGAL 3683
Homo sapiens Primates Integrins INTEGRINS famplex_relations ITGAM 3684
Homo sapiens Primates Integrins INTEGRINS famplex_relations ITGAV 3685
Homo sapiens Primates Integrins INTEGRINS famplex_relations ITGAX 3687
Homo sapiens Primates Integrins INTEGRINS famplex_relations ITGB1 3688
Homo sapiens Primates Integrins INTEGRINS famplex_relations ITGB2 3689
Homo sapiens Primates Integrins INTEGRINS famplex_relations ITGB3 3690
Homo sapiens Primates Integrins INTEGRINS famplex_relations ITGB4 3691
Homo sapiens Primates Integrins INTEGRINS famplex_relations ITGB5 3693
Homo sapiens Primates Integrins INTEGRINS famplex_relations ITGB6 3694
Homo sapiens Primates Integrins INTEGRINS famplex_relations ITGB7 3695
Homo sapiens Primates Integrins INTEGRINS famplex_relations ITGB8 3696
Homo sapiens Primates Integrins INTEGRINS famplex_relations ITGBL1 9358
Homo sapiens Primates GEP GEP ncbigene_synonym GNA12 2768
Homo sapiens Primates GEP GEP ncbigene_synonym GRN 2896
Homo sapiens Primates GTP GTP ncbigene_synonym MTG1 92170
Homo sapiens Primates Rho RHO ncbigene_symbol RHO 6010
Homo sapiens Primates Rho RHO ncbigene_synonym RHOD 29984
Homo sapiens Primates Rho RHO famplex_relations RHOA 387
Homo sapiens Primates Rho RHO famplex_relations RHOB 388
Homo sapiens Primates Rho RHO famplex_relations RHOC 389
Homo sapiens Primates GAP GAP ncbigene_synonym RASA1 5921
Homo sapiens Primates GAP GAP ncbigene_synonym RGS6 9628
Homo sapiens Primates PKN PKN ncbigene_synonym PKN1 5585
Homo sapiens Primates PKN PKN famplex_relations PKN2 5586
Homo sapiens Primates PKN PKN famplex_relations PKN3 29941
Homo sapiens Primates ROCK ROCK famplex_relations ROCK1 6093
Homo sapiens Primates ROCK ROCK famplex_relations ROCK2 9475
Homo sapiens Primates GEF: GEF ncbigene_synonym ARHGEF2 9181
Homo sapiens Primates GEF: GEF ncbigene_synonym SLC2A4RG 56731
Homo sapiens Primates Actin ACTIN famplex_relations ACTA1 58
Homo sapiens Primates Actin ACTIN famplex_relations ACTA2 59
Homo sapiens Primates Actin ACTIN famplex_relations ACTB 60
Homo sapiens Primates Actin ACTIN famplex_relations ACTC1 70
Homo sapiens Primates Actin ACTIN famplex_relations ACTG1 71
Homo sapiens Primates Actin ACTIN famplex_relations ACTG2 72

Chemical mentions

Word Match MeSH Name ChEBI
Guanine Guanine mesh:D006147 guanine chebi:16235
Guanine nucleotide Guanine Nucleotides mesh:D006150 guanosine phosphate chebi:24455

Disease mentions

Word Match MeSH Name DOID