Pathway interactions among HGF/c-Met, PI3K/Akt, and Notch signaling pathways

Schematic representation of pathway interactions among HGF/c-Met, PI3K/Akt, and Notch signaling pathways. Activation of Notch receptor (red) by Delta/Jagged ligands (green) results in translocation of NICD (red oval) to the nucleus (purple), where Hes1 repressor (black) is upregulated, leading to downregulation of PTEN and c-Met transcription., NICD also induces proliferative signaling (green box). Activation of c-Met receptor (brown) by ligand HGF (yellow oval) stimulates PI3K (pink) and pAkt (blue) signaling. Phospho-Akt may interact with NICD in the nucleus, potentially increasing expression of Delta/Jagged ligands.
Pathway interactions among HGF/c-Met, PI3K/Akt, and Notch signaling pathways
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Publication

Activation of Notch-Mediated Protective Signaling in the Myocardium. () Natalie A. Gude, et al. Circ Res. ;102(9):1025-1035. Figure: F8.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates HGF HGF ncbigene_symbol HGF 3082
Homo sapiens Primates HGF HGF ncbigene_synonym IL6 3569
Homo sapiens Primates HGF HGF ncbigene_synonym SOS1 6654
Homo sapiens Primates c-Met C-MET ncbigene_synonym MET 4233
Homo sapiens Primates (Notch NOTCH famplex_relations NOTCH1 4851
Homo sapiens Primates (Notch NOTCH famplex_relations NOTCH2 4853
Homo sapiens Primates (Notch NOTCH famplex_relations NOTCH3 4854
Homo sapiens Primates (Notch NOTCH famplex_relations NOTCH4 4855
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates Delta/Jagged DELTA ncbigene_synonym PSMB6 5694
Homo sapiens Primates Delta/Jagged DELTA ncbigene_synonym YY1 7528
Homo sapiens Primates Delta/Jagged DELTA ncbigene_synonym DLL1 28514
Homo sapiens Primates Hes1 HES1 ncbigene_symbol HES1 3280
Homo sapiens Primates Hes1 HES1 ncbigene_synonym GATD3 8209
Homo sapiens Primates PTEN PTEN ncbigene_symbol PTEN 5728

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID