Genome-Wide Expression Profiling Identifies Type 1 Interferon Response Pathways in Active Tuberculosis

Ingenuity pathway analysis of the genes differentially regulated and common to the three systems described above (in orange). Network of genes in the interferon 1 signaling pathways that were found to be common in active TB patients, BCG-infected THP-1 cells at 20 hours and mice infected with active TB are illustrated. The lines in between genes represent known interactions, with solid lines representing direct interactions and dashed lines representing indirect interactions.
Genome-Wide Expression Profiling Identifies Type 1 Interferon Response Pathways in Active Tuberculosis
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Genome-Wide Expression Profiling Identifies Type 1 Interferon Response Pathways in Active Tuberculosis. (2012) Tom H. M. Ottenhoff, et al. PLoS One. 2012;7(9):e45839. Figure: F7.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates TNFAIP2 TNFAIP2 ncbigene_symbol TNFAIP2 7127
Homo sapiens Primates TRAFD1 TRAFD1 ncbigene_symbol TRAFD1 10906
Homo sapiens Primates MEFV MEFV ncbigene_symbol MEFV 4210
Homo sapiens Primates CD40 CD40 ncbigene_symbol CD40 958
Homo sapiens Primates NFKB(complex) NFKB ncbigene_synonym NFKB1 4790
Homo sapiens Primates NFKB(complex) NFKB famplex_relations RELA 5970
Homo sapiens Primates NFKB(complex) NFKB famplex_relations RELB 5971
Homo sapiens Primates NFKB(complex) NFKB famplex_relations REL 5966
Homo sapiens Primates NFKB(complex) NFKB famplex_relations NFKB2 4791
Homo sapiens Primates GBP4 GBP4 ncbigene_symbol GBP4 115361
Homo sapiens Primates IFNB1 IFNB1 ncbigene_symbol IFNB1 3456
Homo sapiens Primates PIM1 PIM1 ncbigene_symbol PIM1 5292
Homo sapiens Primates PIM1 PIM1 ncbigene_synonym LONP1 9361
Homo sapiens Primates IL12 IL12 famplex_relations IL12A 3592
Homo sapiens Primates IL12 IL12 famplex_relations IL12B 3593
Homo sapiens Primates IFN IFN ncbigene_synonym IFNA1 3439
Homo sapiens Primates Interferon INTERFERON famplex_relations IFNK 56832
Homo sapiens Primates Interferon INTERFERON famplex_relations IFNW1 3467
Homo sapiens Primates Interferon INTERFERON famplex_relations IFNA2 3440
Homo sapiens Primates Interferon INTERFERON famplex_relations IFNA4 3441
Homo sapiens Primates Interferon INTERFERON famplex_relations IFNA5 3442
Homo sapiens Primates Interferon INTERFERON famplex_relations IFNA6 3443
Homo sapiens Primates Interferon INTERFERON famplex_relations IFNA7 3444
Homo sapiens Primates Interferon INTERFERON famplex_relations IFNA8 3445
Homo sapiens Primates Interferon INTERFERON famplex_relations IFNA10 3446
Homo sapiens Primates Interferon INTERFERON famplex_relations IFNA13 3447
Homo sapiens Primates Interferon INTERFERON famplex_relations IFNA14 3448
Homo sapiens Primates Interferon INTERFERON famplex_relations IFNA16 3449
Homo sapiens Primates Interferon INTERFERON famplex_relations IFNA17 3451
Homo sapiens Primates Interferon INTERFERON famplex_relations IFNA21 3452
Homo sapiens Primates IL15RA IL15RA ncbigene_symbol IL15RA 3601
Homo sapiens Primates DDX58 DDX58 ncbigene_synonym RIGI 23586
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations ANGPT1 284
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations ANGPT2 285
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations ANGPT4 51378
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations AREG 374
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations BDNF 627
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations CSF1 1435
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations EFNA1 1942
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations EFNA2 1943
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations EFNA3 1944
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations EFNA4 1945
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations EFNA5 1946
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations EGF 1950
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations EREG 2069
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FGF1 2246
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FGF10 2255
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FGF16 8823
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FGF17 8822
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FGF18 8817
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FGF19 9965
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FGF2 2247
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FGF20 26281
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FGF21 26291
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FGF22 27006
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FGF23 8074
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FGF3 2248
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FGF4 2249
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FGF5 2250
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FGF6 2251
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FGF7 2252
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FGF8 2253
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FGF9 2254
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FLT3LG 2323
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations HGF 3082
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations IGF1 3479
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations IGF2 3481
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations INS 3630
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations KITLG 4254
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations NGF 4803
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations NTF3 4908
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations NTF4 4909
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations PDGFA 5154
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations PDGFB 5155
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations PDGFC 56034
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations PDGFD 80310
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations PGF 5228
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations TGFA 7039
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations VEGFA 7422
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations VEGFB 7423
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations VEGFC 7424
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations VEGFD 2277
Homo sapiens Primates OAS1 OAS1 ncbigene_symbol OAS1 4938
Homo sapiens Primates OAS2 OAS2 ncbigene_symbol OAS2 4939
Homo sapiens Primates UBE2L6 UBE2L6 ncbigene_symbol UBE2L6 9246
Mus musculus Rodents TNFAIP2 TNFAIP2 ncbigene_symbol Tnfaip2 21928
Mus musculus Rodents TRAFD1 TRAFD1 ncbigene_symbol Trafd1 231712
Mus musculus Rodents MEFV MEFV ncbigene_symbol Mefv 54483
Mus musculus Rodents CD40 CD40 ncbigene_symbol Cd40 21939
Mus musculus Rodents NFKB(complex) NFKB ncbigene_synonym Nfkb1 18033
Mus musculus Rodents GBP4 GBP4 ncbigene_symbol Gbp4 17472
Mus musculus Rodents GBP4 GBP4 ncbigene_synonym Gbp3 55932
Mus musculus Rodents IFNB1 IFNB1 ncbigene_symbol Ifnb1 15977
Mus musculus Rodents PIM1 PIM1 ncbigene_symbol Pim1 18712
Mus musculus Rodents IL15RA IL15RA ncbigene_symbol Il15ra 16169
Mus musculus Rodents DDX58 DDX58 ncbigene_synonym Rigi 230073
Mus musculus Rodents OAS1 OAS1 ncbigene_synonym Oas1b 23961
Mus musculus Rodents OAS2 OAS2 ncbigene_symbol Oas2 246728
Mus musculus Rodents IFNA2 IFNA2 ncbigene_symbol Ifna2 15965
Mus musculus Rodents UBE2L6 UBE2L6 ncbigene_symbol Ube2l6 56791

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID