Schematic diagram of the endocytic pathway and the role of retromer in sorting APP and SorL1
Schematic diagram of the endocytic pathway and the role of retromer in sorting APP and SorL1. The SorL1 protein associates with APP. The cargo-selective retromer complex interacts with SorL1 to direct the APP-SorL1 complex into an endosome-to-Golgi retrieval pathway. Aberrant APP localization to late endosomal compartments increases processing to the neurotoxic Aβ peptide.
Publication
Identification of Alzheimer disease associated variants in genes that regulate retromer function. () Badri N. Vardarajan, et al. Neurobiol Aging. ;33(9):2231.e15-2231.e30. Figure: F1.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Drosophila melanogaster | Invertebrates | VPS35 | VPS35 | ncbigene_symbol | Vps35 | 37536 |
| Drosophila melanogaster | Invertebrates | early | EARLY | ncbigene_synonym | lds | 45894 |
| Drosophila melanogaster | Invertebrates | VPS26 | VPS26 | ncbigene_symbol | Vps26 | 31144 |
| Drosophila melanogaster | Invertebrates | VPS29 | VPS29 | ncbigene_symbol | Vps29 | 33295 |
| Schizosaccharomyces pombe | Plants and Fungi | VPS35 | VPS35 | ncbigene_symbol | vps35 | 2539462 |
| Schizosaccharomyces pombe | Plants and Fungi | VPS26 | VPS26 | ncbigene_symbol | vps26 | 2543395 |
| Schizosaccharomyces pombe | Plants and Fungi | VPS29 | VPS29 | ncbigene_symbol | vps29 | 2542802 |
| Caenorhabditis elegans | Invertebrates | VPS35 | VPS35 | ncbigene_symbol | vps-35 | 174000 |
| Caenorhabditis elegans | Invertebrates | VPS26 | VPS26 | ncbigene_symbol | vps-26 | 177764 |
| Caenorhabditis elegans | Invertebrates | VPS29 | VPS29 | ncbigene_symbol | vps-29 | 176424 |
| Word | Match | MeSH | Name | ChEBI |
|---|
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|