Phospholipid biosynthetic pathways

Phospholipid biosynthetic pathways. PE is made by the CDP-ethanolamine pathway in the ER (left) or from PS via the action of PSD in mitochondria. PC is made by the CDP-choline pathway (right) or from PE through the PEMT pathway in the ER and mitochondria-associated membranes of the ER. PS is produced from PE and PC via PSS2 and PSS1 pathways in the mitochondria associated membranes of the ER. Ethanolamine kinase: EthK; CTP: ethanolaminephosphate; cytidylyltransferase: ET; CDP: diacylglycerol ethanolamine and choline phosphotransferases: EPT and CPT; choline kinase: CK; CTP: cholinephosphate cytidylyltransferase: CT; CDP: diacylglycerol choline and ethanolamine phosphotransferases: CPT and EPT; Phosphatidylethanolamine N-methyltransferase: PEMT; phosphatidylserine synthase 1: PSS1; phosphatidylserine synthase 2: PSS2.
Phospholipid biosynthetic pathways
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PMC

Publication

Forms, Crosstalks, and the Role of Phospholipid Biosynthesis in Autophagy. (2012) Leanne Pereira, et al. Int J Cell Biol. 2012;2012:931956. Figure: F7.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Drosophila melanogaster Invertebrates Eth ETH ncbigene_symbol ETH 44125
Drosophila melanogaster Invertebrates Eth ETH ncbigene_synonym Calr 41166
Drosophila melanogaster Invertebrates Pcyt2 PCYT2 ncbigene_symbol Pcyt2 38180
Drosophila melanogaster Invertebrates ET ET ncbigene_symbol et 32975
Drosophila melanogaster Invertebrates Pcyt1 PCYT1 ncbigene_symbol Pcyt1 117353
Drosophila melanogaster Invertebrates CT/Pcyt1 CT ncbigene_symbol ct 44540
Drosophila melanogaster Invertebrates EPT EPT ncbigene_synonym bbc 36496
Drosophila melanogaster Invertebrates EPT EPT ncbigene_synonym TSG101 39881
Drosophila melanogaster Invertebrates CPT CPT ncbigene_symbol Cpt 248169
Drosophila melanogaster Invertebrates CPT CPT ncbigene_synonym CG7149 34063
Drosophila melanogaster Invertebrates CPT CPT ncbigene_synonym CPT2 38355
Drosophila melanogaster Invertebrates →PC PC ncbigene_symbol Pc 40358
Drosophila melanogaster Invertebrates PE PE ncbigene_symbol pe 252319
Drosophila melanogaster Invertebrates PSD PSD ncbigene_symbol psd 33830
Drosophila melanogaster Invertebrates PSD PSD ncbigene_synonym Pisd 42849
Drosophila melanogaster Invertebrates PS PS ncbigene_symbol ps 44258
Homo sapiens Primates Chol CHO1 ncbigene_synonym KIF23 9493
Homo sapiens Primates Pcyt2 PCYT2 ncbigene_symbol PCYT2 5833
Homo sapiens Primates Pcyt1 PCYT1 ncbigene_synonym PCYT1A 5130
Homo sapiens Primates EPT EPT ncbigene_synonym LGI1 9211
Homo sapiens Primates CPT CPT ncbigene_synonym CHPT1 56994
Homo sapiens Primates CPT CPT ncbigene_synonym DHDDS 79947
Homo sapiens Primates PEMT PEMT ncbigene_symbol PEMT 10400
Homo sapiens Primates PEMT PEMT ncbigene_synonym MUC1 4582
Homo sapiens Primates →PC PC ncbigene_symbol PC 5091
Homo sapiens Primates PSD PSD ncbigene_symbol PSD 5662
Homo sapiens Primates PSD PSD ncbigene_synonym PISD 23761
Homo sapiens Primates PSD PSD ncbigene_synonym FBXL15 79176
Homo sapiens Primates PSS2 PSS2 ncbigene_synonym TGM5 9333
Homo sapiens Primates PSS2 PSS2 ncbigene_synonym PTDSS2 81490
Homo sapiens Primates PSS1 PSS1 ncbigene_synonym CDSN 1041
Homo sapiens Primates PSS1 PSS1 ncbigene_synonym PTDSS1 9791
Homo sapiens Primates PSS1 PSS1 ncbigene_synonym CARD14 79092
Homo sapiens Primates TAG TAG ncbigene_synonym TMED7 51014
Homo sapiens Primates TAG TAG ncbigene_synonym LINC01194 404663

Chemical mentions

Word Match MeSH Name ChEBI
CDP Cytidine Diphosphate mesh:D003565 CDP chebi:17239

Disease mentions

Word Match MeSH Name DOID