FLCN pathway

FLCN pathway. (a) FLCN is the gene associated with BHD. Normal FCLN protein complexes with FNIP1, FNIP2, and AMPK. This complex is phosphorylated by a rapamycin-sensitive kinase (mTORC1). (b) When FLCN is altered, it fails to complex and allows activation of AKT, mTORC1, and mTORC2. (From Hasumi et al. [], with permission.)
FLCN pathway
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Publication

Familial Renal Cancer: Molecular Genetics and Surgical Management. (2011) Glen W. Barrisford, et al. Int J Surg Oncol. 2011;2011:658767. Figure: F5.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates FLCN+ FLCN ncbigene_symbol FLCN 201163
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations ANGPT1 284
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations ANGPT2 285
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations ANGPT4 51378
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations AREG 374
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations BDNF 627
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations CSF1 1435
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations EFNA1 1942
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations EFNA2 1943
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations EFNA3 1944
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations EFNA4 1945
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations EFNA5 1946
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations EGF 1950
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations EREG 2069
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FGF1 2246
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FGF10 2255
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FGF16 8823
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FGF17 8822
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FGF18 8817
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FGF19 9965
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FGF2 2247
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FGF20 26281
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FGF21 26291
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FGF22 27006
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FGF23 8074
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FGF3 2248
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FGF4 2249
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FGF5 2250
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FGF6 2251
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FGF7 2252
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FGF8 2253
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FGF9 2254
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FLT3LG 2323
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations HGF 3082
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations IGF1 3479
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations IGF2 3481
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations INS 3630
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations KITLG 4254
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations NGF 4803
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations NTF3 4908
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations NTF4 4909
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations PDGFA 5154
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations PDGFB 5155
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations PDGFC 56034
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations PDGFD 80310
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations PGF 5228
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations TGFA 7039
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations VEGFA 7422
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations VEGFB 7423
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations VEGFC 7424
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations VEGFD 2277
Homo sapiens Primates P13K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates P13K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates P13K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates P13K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates P13K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates P13K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates P13K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates P13K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates P13K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates P13K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates PTEN PTEN ncbigene_symbol PTEN 5728
Homo sapiens Primates Akt AKT ncbigene_synonym AKT1 207
Homo sapiens Primates Akt AKT famplex_relations AKT2 208
Homo sapiens Primates Akt AKT famplex_relations AKT3 10000
Homo sapiens Primates mTORC2 MTORC2 famplex_relations MAPKAP1 79109
Homo sapiens Primates mTORC2 MTORC2 famplex_relations MTOR 2475
Homo sapiens Primates mTORC2 MTORC2 famplex_relations RICTOR 253260
Homo sapiens Primates mTORC2 MTORC2 famplex_relations MLST8 64223
Homo sapiens Primates TSC2 TSC2 ncbigene_symbol TSC2 7249
Homo sapiens Primates FoxO FOXO famplex_relations FOXO1 2308
Homo sapiens Primates FoxO FOXO famplex_relations FOXO3 2309
Homo sapiens Primates FoxO FOXO famplex_relations FOXO4 4303
Homo sapiens Primates FoxO FOXO famplex_relations FOXO6 100132074
Homo sapiens Primates GSK3 GSK3 famplex_relations GSK3A 2931
Homo sapiens Primates GSK3 GSK3 famplex_relations GSK3B 2932
Homo sapiens Primates BAD BAD ncbigene_symbol BAD 572
Homo sapiens Primates LKB1 LKB1 ncbigene_synonym STK11 6794
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAA1 5562
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAA2 5563
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAB1 5564
Homo sapiens Primates AMPK AMPK famplex_relations PRKAB2 5565
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG1 5571
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG2 51422
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG3 53632
Homo sapiens Primates S6K S6K ncbigene_synonym RPS6KB1 6198
Homo sapiens Primates FNIP2 FNIP2 ncbigene_symbol FNIP2 57600
Homo sapiens Primates FNIP1 FNIP1 ncbigene_symbol FNIP1 96459
Mus musculus Rodents FLCN+ FLCN ncbigene_symbol Flcn 216805
Mus musculus Rodents P13K PI3K ncbigene_synonym Pik3r1 18708
Mus musculus Rodents PTEN PTEN ncbigene_symbol Pten 19211
Mus musculus Rodents Akt AKT ncbigene_synonym Akt1 11651
Mus musculus Rodents TSC2 TSC2 ncbigene_symbol Tsc2 22084
Mus musculus Rodents GSK3 GSK3 ncbigene_synonym Gsk3b 56637
Mus musculus Rodents BAD BAD ncbigene_symbol Bad 12015
Mus musculus Rodents LKB1 LKB1 ncbigene_synonym Stk11 20869
Mus musculus Rodents S6K S6K ncbigene_synonym Rps6kb1 72508
Mus musculus Rodents FNIP2 FNIP2 ncbigene_symbol Fnip2 329679
Mus musculus Rodents FNIP1 FNIP1 ncbigene_symbol Fnip1 216742
Drosophila melanogaster Invertebrates P13K PI3K ncbigene_synonym Pi3K21B 33203
Drosophila melanogaster Invertebrates P13K PI3K ncbigene_synonym Pi3K59F 37733
Drosophila melanogaster Invertebrates P13K PI3K ncbigene_synonym Pi3K68D 39329
Drosophila melanogaster Invertebrates P13K PI3K ncbigene_synonym Pi3K92E 42446
Drosophila melanogaster Invertebrates PTEN PTEN ncbigene_symbol Pten 43991
Drosophila melanogaster Invertebrates Akt AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates TSC2 TSC2 ncbigene_synonym gig 40201
Drosophila melanogaster Invertebrates FoxO FOXO ncbigene_symbol foxo 41709
Drosophila melanogaster Invertebrates GSK3 GSK3 ncbigene_synonym sgg 31248
Drosophila melanogaster Invertebrates BAD BAD ncbigene_synonym cass 35053
Drosophila melanogaster Invertebrates LKB1 LKB1 ncbigene_symbol Lkb1 41673
Drosophila melanogaster Invertebrates and AND ncbigene_synonym CkIIbeta 32132
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Andorra 32798
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Anp 43595
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Acam 44913
Drosophila melanogaster Invertebrates AMPK AMPK ncbigene_synonym SNF4Agamma 42515
Drosophila melanogaster Invertebrates AMPK AMPK ncbigene_synonym AMPKalpha 43904
Drosophila melanogaster Invertebrates S6K S6K ncbigene_symbol S6k 38654

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID
Cancer NA