Coordinately up-regulated TCA cycle genes in CD8+ T cells from the VIR group (VIR versus LTNP) illustrated in TCA cycle pathway from Kyoto Encyclopedia of Genes and Genomes (KEGG; http://www.genome.jp/kegg/). The enzymes encoded by coordinately up-regulated TCA cycle genes are highlighted in red and these include ATP citrate lyase (EC:2.3.3.8; gene symbol ACLY), aconitase 1, soluble and aconitase 2, mitochondrial (EC:4.2.1.3; gene symbol ACO1 and ACO2), isocitrate dehydrogenase 2 (NADP+), mitochondrial (EC:1.1.1.42; gene symbol IDH2), isocitrate dehydrogenase 3 (NAD+) gamma (EC:1.1.1.41; gene symbol IDH3G), oxoglutarate (alpha-ketoglutarate) dehydrogenase (EC:1.2.4.2; gene symbol OGDH), succinate-CoA ligase, alpha subunit (EC:6.2.1.4; gene symbol SUCLG1), succinate-CoA ligase, ADP-forming, beta subunit (EC:6.2.1.5; gene symbol SUCLG2), succinate dehydrogenase complex, subunit C (EC:1.3.5.1; gene symbol SDHC), fumarate hydratase (EC:4.2.1.2; gene symbol FH), malate dehydrogenase 1 and 2, (EC:1.1.1.37; gene symbol MDH1 and MDH2), and phosphoenolpyruvate carboxykinase 2 (mitochondrial) (EC:4.1.1.32; gene symbol PCK2). Coordinately up-regulated pathways, which are closely articulated with the TCA cycle, are highlighted by red rectangles. The TCA cycle intermediates linked to other pathways are highlighted by red circles.
Genome-wide analysis of primary CD4+ and CD8+ T cell transcriptomes shows evidence for a network of enriched pathways associated with HIV disease. (2011)
Jing Qin Wu, et al. Retrovirology. 2011;8:18-18. Figure: F4.
