Arsenic: a potentially useful poison for Hedgehog-driven cancers

The schematic linearly shows activation of Hh signaling after binding of Hh ligand to the Patched (Ptc) receptor. This results in subsequent localization of the Smo transmembrane protein to the primary cilium, where further signal transduction occurs after proteolytic processing of GLI2 to an activator form, resulting in GLI2 nuclear translocation to transcriptionally activate Hh target genes. Smo inhibitors that are currently in clinical trials for human cancers are shown. ATO inhibits GLI1 and GLI2 proteins downstream of the Smo protein through similar, yet slightly distinct, mechanisms of action (, ).
Arsenic: a potentially useful poison for Hedgehog-driven cancers
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Publication

Arsenic: a potentially useful poison for Hedgehog-driven cancers. (2011) G. Praveen Raju. J Clin Invest. 2011 Jan 4;121(1):14-16. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Drosophila melanogaster Invertebrates Hh HH ncbigene_symbol hh 42737
Drosophila melanogaster Invertebrates Ptc PTC ncbigene_symbol ptc 35851
Drosophila melanogaster Invertebrates Smo SMO ncbigene_symbol smo 33196
Drosophila melanogaster Invertebrates Smo SMO ncbigene_synonym sm 37254
Drosophila melanogaster Invertebrates ATO ATO ncbigene_symbol ato 40975
Homo sapiens Primates Ptc PTC ncbigene_synonym F9 2158
Homo sapiens Primates Ptc PTC ncbigene_synonym TAS2R38 5726
Homo sapiens Primates Ptc PTC ncbigene_synonym PTCH1 5727
Homo sapiens Primates Ptc PTC ncbigene_synonym RET 5979
Homo sapiens Primates Ptc PTC ncbigene_synonym CCDC6 8030
Homo sapiens Primates Smo SMO ncbigene_symbol SMO 6608
Homo sapiens Primates Smo SMO ncbigene_synonym SMOX 54498
Homo sapiens Primates GLI2 GLI2 ncbigene_symbol GLI2 2736
Homo sapiens Primates GLI1 GLI1 ncbigene_symbol GLI1 2735

Chemical mentions

Word Match MeSH Name ChEBI
IPI-926 NA mesh:C541444
BMS-833923 NA mesh:C583051

Disease mentions

Word Match MeSH Name DOID