ERAlpha-Negative and Triple Negative Breast Cancer: Molecular Features and Potential Therapeutic Approaches

E2/ERβ-mediated signaling pathways and Interaction with BRCA1; 2) E2/GRCP-30/EGFR signaling pathway; 3) CXCL8 and related CXC Chemokines; 4) MicroRNA signatures; 5) Notch/Suvivin; 6) Akt; 7) E-cadherin/E-Selectin and 8) Osteoponin are shown. Basic shapes filled with colors indicate increased expression; Basic shapes filled without color [] indicate loss or reduced levels of the indicated proteins/receptors
ERAlpha-Negative and Triple Negative Breast Cancer: Molecular Features and Potential Therapeutic Approaches
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ERα-Negative and Triple Negative Breast Cancer: Molecular Features and Potential Therapeutic Approaches. () Jin-Qiang Chen, et al. Biochim Biophys Acta. ;1796(2):162-175. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates ATP ATP ncbigene_synonym ATP8A2 51761
Homo sapiens Primates Her-2 HER-2 ncbigene_synonym ERBB2 2064
Homo sapiens Primates AC ADCY famplex_relations ADCY1 107
Homo sapiens Primates AC ADCY famplex_relations ADCY2 108
Homo sapiens Primates AC ADCY famplex_relations ADCY3 109
Homo sapiens Primates AC ADCY famplex_relations ADCY4 196883
Homo sapiens Primates AC ADCY famplex_relations ADCY5 111
Homo sapiens Primates AC ADCY famplex_relations ADCY6 112
Homo sapiens Primates AC ADCY famplex_relations ADCY7 113
Homo sapiens Primates AC ADCY famplex_relations ADCY8 114
Homo sapiens Primates AC ADCY famplex_relations ADCY9 115
Homo sapiens Primates AC ADCY famplex_relations ADCY10 55811
Homo sapiens Primates EGFR EGFR ncbigene_symbol EGFR 1956
Homo sapiens Primates ERa- ERA ncbigene_synonym ESR1 2099
Homo sapiens Primates ERa- ERA ncbigene_synonym ERAL1 26284
Homo sapiens Primates Notch NOTCH famplex_relations NOTCH1 4851
Homo sapiens Primates Notch NOTCH famplex_relations NOTCH2 4853
Homo sapiens Primates Notch NOTCH famplex_relations NOTCH3 4854
Homo sapiens Primates Notch NOTCH famplex_relations NOTCH4 4855
Homo sapiens Primates MAPK MAPK famplex_relations MAPK1 5594
Homo sapiens Primates MAPK MAPK famplex_relations MAPK3 5595
Homo sapiens Primates MAPK MAPK famplex_relations MAPK11 5600
Homo sapiens Primates MAPK MAPK famplex_relations MAPK12 6300
Homo sapiens Primates MAPK MAPK famplex_relations MAPK13 5603
Homo sapiens Primates MAPK MAPK famplex_relations MAPK14 1432
Homo sapiens Primates MAPK MAPK famplex_relations MAPK8 5599
Homo sapiens Primates MAPK MAPK famplex_relations MAPK9 5601
Homo sapiens Primates MAPK MAPK famplex_relations MAPK10 5602
Homo sapiens Primates ERB ERB ncbigene_synonym ESR2 2100
Homo sapiens Primates AKT AKT ncbigene_synonym AKT1 207
Homo sapiens Primates AKT AKT famplex_relations AKT2 208
Homo sapiens Primates AKT AKT famplex_relations AKT3 10000
Homo sapiens Primates miR-221 MIR-221 ncbigene_synonym MIR221 407006
Homo sapiens Primates E-Cadherin CDH1 ncbigene_symbol CDH1 999
Homo sapiens Primates E-Cadherin CDH1 ncbigene_synonym FZR1 51343
Homo sapiens Primates miR-222 MIR-222 ncbigene_synonym MIR222 407007
Homo sapiens Primates CXCL2 CXCL2 ncbigene_symbol CXCL2 2920
Homo sapiens Primates miR-206 MIR-206 ncbigene_synonym MIR206 406989
Homo sapiens Primates CXCL4 CXCL4 ncbigene_synonym PF4 5196
Homo sapiens Primates miR-22 MIR-22 ncbigene_synonym MIR22 407004
Homo sapiens Primates CXCL3 CXCL3 ncbigene_symbol CXCL3 2921
Homo sapiens Primates CXCL7 CXCL7 ncbigene_synonym PPBP 5473
Homo sapiens Primates CXCL6 CXCL6 ncbigene_symbol CXCL6 6372
Drosophila melanogaster Invertebrates ATP ATP ncbigene_synonym ATPsynbeta 43829
Drosophila melanogaster Invertebrates ATP ATP ncbigene_synonym Atpalpha 48971
Drosophila melanogaster Invertebrates AC AC ncbigene_symbol ac 30981
Drosophila melanogaster Invertebrates PR+ PR ncbigene_symbol pr 35292
Drosophila melanogaster Invertebrates EGFR EGFR ncbigene_symbol Egfr 37455
Drosophila melanogaster Invertebrates ERa- ERA ncbigene_symbol era 5658294
Drosophila melanogaster Invertebrates Notch NOTCH ncbigene_synonym NA 31293
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym MKP-4 32963
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym p38b 34780
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym rl 3354888
Drosophila melanogaster Invertebrates AKT AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates E-Cadherin E-CADHERIN ncbigene_synonym shg 37386

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID