The regulation of miR-203 expression in differentiating normal and HPV-positive epithelia

Model for the regulation of miR-203 expression in differentiating normal and HPV-positive epithelia. miR-203 expression is increased upon differentiation of normal keratinocytes, leading to suppression of p63 translation in suprabasal cells. In HPV-infected epithelia, E7 blocks miR-203 upregulation through the MAP kinase pathway, leading to increased levels of p63, cells remaining active in the cell cycle, and HPV genome amplification. EGF, epidermal growth factor.
The regulation of miR-203 expression in differentiating normal and HPV-positive epithelia
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Publication

Human Papillomaviruses Modulate Expression of MicroRNA 203 upon Epithelial Differentiation to Control Levels of p63 Proteins . (2010) Marta Melar-New, et al. J Virol. 2010 May;84(10):5212-5221. Figure: F6.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates miR-203 MIR-203 ncbigene_synonym MIR203A 406986
Homo sapiens Primates p63 P63 ncbigene_synonym RPE65 6121
Homo sapiens Primates p63 P63 ncbigene_synonym UVRAG 7405
Homo sapiens Primates p63 P63 ncbigene_synonym TP63 8626
Homo sapiens Primates p63 P63 ncbigene_synonym CKAP4 10970
Homo sapiens Primates NFKB] NFKB ncbigene_synonym NFKB1 4790
Homo sapiens Primates NFKB] NFKB famplex_relations RELA 5970
Homo sapiens Primates NFKB] NFKB famplex_relations RELB 5971
Homo sapiens Primates NFKB] NFKB famplex_relations REL 5966
Homo sapiens Primates NFKB] NFKB famplex_relations NFKB2 4791
Homo sapiens Primates [AP-1,SP1,NFKB] SP1 ncbigene_symbol SP1 6667
Homo sapiens Primates [AP-1,SP1,NFKB] SP1 ncbigene_synonym PSG1 5669
Homo sapiens Primates [AP-1,SP1,NFKB] SP1 ncbigene_synonym DAND5 199699
Homo sapiens Primates [AP-1, AP1 ncbigene_synonym FOS 2353
Homo sapiens Primates [AP-1, AP1 ncbigene_synonym FOSB 2354
Homo sapiens Primates [AP-1, AP1 ncbigene_synonym JUN 3725
Homo sapiens Primates [AP-1, AP1 ncbigene_synonym JUNB 3726
Homo sapiens Primates [AP-1, AP1 ncbigene_synonym JUND 3727
Homo sapiens Primates [AP-1, AP1 famplex_relations FOSL1 8061
Homo sapiens Primates [AP-1, AP1 famplex_relations FOSL2 2355
Homo sapiens Primates MAP MAP ncbigene_synonym SGSM3 27352
Homo sapiens Primates [Ca?,EGF] EGF ncbigene_symbol EGF 1950
Drosophila melanogaster Invertebrates Loss LOS ncbigene_synonym mid 33770
Drosophila melanogaster Invertebrates low LOW ncbigene_symbol Low 44325
Drosophila melanogaster Invertebrates p63 P63 ncbigene_synonym ref(2)P 35246
Drosophila melanogaster Invertebrates p63 P63 ncbigene_synonym wash 36311
Drosophila melanogaster Invertebrates p63 P63 ncbigene_synonym SH3PX1 39136
Drosophila melanogaster Invertebrates NFKB] NFKB ncbigene_synonym Dif 35045
Drosophila melanogaster Invertebrates NFKB] NFKB ncbigene_synonym dl 35047
Drosophila melanogaster Invertebrates NFKB] NFKB ncbigene_synonym Rel 41087
Drosophila melanogaster Invertebrates [AP-1,SP1,NFKB] SP1 ncbigene_symbol Sp1 31913
Drosophila melanogaster Invertebrates [AP-1,SP1,NFKB] SP1 ncbigene_synonym grass 43273
Drosophila melanogaster Invertebrates [AP-1,SP1,NFKB] SP1 ncbigene_synonym Spn42Dd 49808
Drosophila melanogaster Invertebrates [AP-1, AP1 ncbigene_synonym AP-1gamma 31842
Drosophila melanogaster Invertebrates [AP-1, AP1 ncbigene_synonym Jra 36057
Drosophila melanogaster Invertebrates [AP-1, AP1 ncbigene_synonym kay 3772082
Drosophila melanogaster Invertebrates MAP MAP ncbigene_synonym mapP 45332
Drosophila melanogaster Invertebrates [Ca?, CA ncbigene_symbol ca 43518
Drosophila melanogaster Invertebrates [Ca?,EGF] EGF ncbigene_synonym Egfr 37455

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID