Simplified diagram of the angiogenesis pathway with anti-angiogenic targets and select compounds exploiting them

A simplified diagram of the angiogenesis pathway with anti-angiogenic targets and select compounds exploiting them. Legend: VEGF: vascular endothelial growth factor, bFGF: fibroblast growth factor, PDGF: platelet derived growth factor, AT-III: antithrombin III, PSMA: prostate specific membrane antigen.
Simplified diagram of the angiogenesis pathway with anti-angiogenic targets and select compounds exploiting them
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Publication

Angiogenesis Inhibitors in the treatment of Prostate Cancer. () Paul G. Kluetz, et al. Expert Opin Pharmacother. ;11(2):233-247. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Drosophila melanogaster Invertebrates -VEGF VEGF ncbigene_synonym Pvf1 32876
Drosophila melanogaster Invertebrates -VEGF VEGF ncbigene_synonym Pvf2 33994
Drosophila melanogaster Invertebrates -VEGF VEGF ncbigene_synonym Pvf3 33995
Drosophila melanogaster Invertebrates -VEGF VEGF ncbigene_synonym Pvr 34127
Drosophila melanogaster Invertebrates PKC PKC ncbigene_synonym inaC 36897
Drosophila melanogaster Invertebrates PKC PKC ncbigene_synonym Pkc98E 43428
Drosophila melanogaster Invertebrates PKC PKC ncbigene_synonym aPKC 47594
Drosophila melanogaster Invertebrates PKC PKC ncbigene_synonym Pkc53E 48311
Drosophila melanogaster Invertebrates Abs ABS ncbigene_symbol abs 40530
Drosophila melanogaster Invertebrates EC EC ncbigene_symbol ec 31339
Drosophila melanogaster Invertebrates RET RET ncbigene_symbol Ret 43875
Drosophila melanogaster Invertebrates RET RET ncbigene_synonym reticulated 44319
Drosophila melanogaster Invertebrates RET RET ncbigene_synonym reti 252522
Drosophila melanogaster Invertebrates RET RET ncbigene_synonym rets 252556
Drosophila melanogaster Invertebrates RAF RAF ncbigene_symbol Raf 31221
Drosophila melanogaster Invertebrates c-KIT KIT ncbigene_synonym blo 45828
Homo sapiens Primates -VEGF VEGF ncbigene_synonym VEGFA 7422
Homo sapiens Primates -VEGF VEGF famplex_relations VEGFB 7423
Homo sapiens Primates -VEGF VEGF famplex_relations VEGFC 7424
Homo sapiens Primates -VEGF VEGF famplex_relations VEGFD 2277
Homo sapiens Primates -VEGF VEGF famplex_relations PGF 5228
Homo sapiens Primates BFGF BFGF ncbigene_synonym FGF2 2247
Homo sapiens Primates PDGF PDGF famplex_relations PDGFA 5154
Homo sapiens Primates PDGF PDGF famplex_relations PDGFB 5155
Homo sapiens Primates PDGF PDGF famplex_relations PDGFC 56034
Homo sapiens Primates PDGF PDGF famplex_relations PDGFD 80310
Homo sapiens Primates AT-II AT2 ncbigene_synonym AGTR2 186
Homo sapiens Primates AT-II AT2 ncbigene_synonym PGR-AS1 101054525
Homo sapiens Primates PKC PKC ncbigene_synonym PRRT2 112476
Homo sapiens Primates PKC PKC famplex_relations PRKCA 5578
Homo sapiens Primates PKC PKC famplex_relations PRKCB 5579
Homo sapiens Primates PKC PKC famplex_relations PRKCD 5580
Homo sapiens Primates PKC PKC famplex_relations PRKCE 5581
Homo sapiens Primates PKC PKC famplex_relations PRKCG 5582
Homo sapiens Primates PKC PKC famplex_relations PRKCH 5583
Homo sapiens Primates PKC PKC famplex_relations PRKCI 5584
Homo sapiens Primates PKC PKC famplex_relations PRKCQ 5588
Homo sapiens Primates PKC PKC famplex_relations PRKCZ 5590
Homo sapiens Primates PKC PKC famplex_relations PRKD3 23683
Homo sapiens Primates Abs ABS ncbigene_synonym DDX41 51428
Homo sapiens Primates PSMA PSMA ncbigene_synonym FOLH1 2346
Homo sapiens Primates VEGFR VEGFR ncbigene_synonym KDR 3791
Homo sapiens Primates VEGFR VEGFR famplex_relations FLT1 2321
Homo sapiens Primates VEGFR VEGFR famplex_relations FLT4 2324
Homo sapiens Primates PDGFR PDGFR ncbigene_synonym PDGFRB 5159
Homo sapiens Primates PDGFR PDGFR famplex_relations PDGFRA 5156
Homo sapiens Primates RET RET ncbigene_symbol RET 5979
Homo sapiens Primates RAF RAF ncbigene_synonym ZHX2 22882
Homo sapiens Primates RAF RAF famplex_relations ARAF 369
Homo sapiens Primates RAF RAF famplex_relations BRAF 673
Homo sapiens Primates RAF RAF famplex_relations RAF1 5894
Homo sapiens Primates FLT-3 FLT3 ncbigene_symbol FLT3 2322
Homo sapiens Primates c-KIT C-KIT ncbigene_synonym KIT 3815

Chemical mentions

Word Match MeSH Name ChEBI
Vandetanib vandetanib mesh:C452423 N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine chebi:49960
Cediranib NA mesh:C500926
Enzastaurin NA mesh:C504878
Pazopanib pazopanib mesh:C516667 pazopanib chebi:71219
Thalidomide Thalidomide mesh:D013792 thalidomide chebi:9513
threonine Threonine mesh:D013912 L-threonine chebi:16857
Angiostatin NA mesh:D043168
Endostatin NA mesh:D043169

Disease mentions

Word Match MeSH Name DOID
Cancer NA