A genetic model for sex determination, controlled by a balance of antagonistic pathways
A genetic model for sex determination, controlled by a balance of antagonistic pathways. In XY gonads, Sry triggers upregulation of Sox9, leading to Sertoli cell commitment and testicular differentiation. Sertoli cell differentiation is a result of the establishment of a positive feedback loop between Sox9 and secretion of Fgf9 (and also PGD2; not shown), which act in a paracrine manner to recruit additional Sertoli cells. In XX gonads, two independent signaling pathways involving the Rspo1/Wnt4/β-catenin pathway and Foxl2 tilt the balance towards the female side and silence Sox9 and Fgf9. Arrows indicate stimulation; T bars indicate inhibition.
Publication
Complementary pathways in mammalian female sex determination. (2009) Serge Nef, et al. J Biol. 2009;8(8):74-74. Figure: F1.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Capra hircus | Mammals | Sox9 | SOX9 | ncbigene_symbol | SOX9 | 106503295 |
| Capra hircus | Mammals | Wnt4 | WNT4 | ncbigene_symbol | WNT4 | 102187819 |
| Capra hircus | Mammals | Rspo1 | RSPO1 | ncbigene_symbol | RSPO1 | 100860770 |
| Capra hircus | Mammals | Fgf9 | FGF9 | ncbigene_symbol | FGF9 | 102169602 |
| Capra hircus | Mammals | Sry | SRY | ncbigene_symbol | SRY | 108634533 |
| Capra hircus | Mammals | Foxl2 | FOXL2 | ncbigene_symbol | FOXL2 | 102191377 |
| Capra hircus | Mammals | Foxl2 | FOXI2 | ncbigene_symbol | FOXI2 | 108634016 |
| Capra hircus | Mammals | -B-catenin- | CTNNB1 | ncbigene_symbol | CTNNB1 | 102191742 |
| Capra hircus | Mammals | -B-catenin- | CTNNB1 | ncbigene_synonym | CTNND1 | 102183255 |
| Mus musculus | Rodents | Sox9 | SOX9 | ncbigene_symbol | Sox9 | 20682 |
| Mus musculus | Rodents | Wnt4 | WNT4 | ncbigene_symbol | Wnt4 | 22417 |
| Mus musculus | Rodents | Rspo1 | RSPO1 | ncbigene_symbol | Rspo1 | 192199 |
| Mus musculus | Rodents | Fgf9 | FGF9 | ncbigene_symbol | Fgf9 | 14180 |
| Mus musculus | Rodents | Sry | SRY | ncbigene_symbol | Sry | 21674 |
| Mus musculus | Rodents | Foxl2 | FOXL2 | ncbigene_symbol | Foxl2 | 26927 |
| Mus musculus | Rodents | Foxl2 | FOXI2 | ncbigene_symbol | Foxi2 | 270004 |
| Mus musculus | Rodents | -B-catenin- | CTNNB1 | ncbigene_symbol | Ctnnb1 | 12387 |
| Homo sapiens | Primates | Sox9 | SOX9 | ncbigene_symbol | SOX9 | 6662 |
| Homo sapiens | Primates | Wnt4 | WNT4 | ncbigene_symbol | WNT4 | 54361 |
| Homo sapiens | Primates | Rspo1 | RSPO1 | ncbigene_symbol | RSPO1 | 284654 |
| Homo sapiens | Primates | Fgf9 | FGF9 | ncbigene_symbol | FGF9 | 2254 |
| Homo sapiens | Primates | Sry | SRY | ncbigene_symbol | SRY | 6736 |
| Homo sapiens | Primates | Foxl2 | FOXL2 | ncbigene_symbol | FOXL2 | 668 |
| Homo sapiens | Primates | Foxl2 | FOXI2 | ncbigene_symbol | FOXI2 | 399823 |
| Homo sapiens | Primates | -B-catenin- | CTNNB1 | ncbigene_symbol | CTNNB1 | 1499 |
| Danio rerio | Vertebrates | Wnt4 | WNT4 | ncbigene_symbol | wnt4 | 30123 |
| Danio rerio | Vertebrates | Rspo1 | RSPO1 | ncbigene_symbol | rspo1 | 436625 |
| Danio rerio | Vertebrates | Fgf9 | FGF9 | ncbigene_symbol | fgf9 | 101883614 |
| Danio rerio | Vertebrates | Foxl2 | FOXL2 | ncbigene_synonym | foxl2a | 692279 |
| Danio rerio | Vertebrates | Foxl2 | FOXI2 | ncbigene_symbol | foxi2 | 387256 |
| Danio rerio | Vertebrates | -B-catenin- | CTNNB1 | ncbigene_symbol | ctnnb1 | 30265 |
| Word | Match | MeSH | Name | ChEBI |
|---|
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|