Retromer sorting pathway is made up of a coat complex that binds and transports transmembrane receptors between the endosome and the trans-Golgi network (TGN)

The retromer sorting pathway is made up of a coat complex that binds and transports transmembrane receptors between the endosome and the trans-Golgi network (TGN). In yeast, the coat complex, made up of vacuolar protein sorting (VPS) 35, VPS26, VPS29, VPS5, and VPS17, binds and transports VPS10 from the endosome back to the TGN (red arrow). In nonneuronal mammalian cells, the coat complex, made up of VPS35, VPS26, VPS29, VPS5, and VPS17, binds and transports the mannose-6-phosphate (M6PR) and the polymeric immunoglobulin (PIGR) receptors from the cell surface to endosome and from endosome back to the TGN (red arrows). In neurons, the coat complex binds and transports the family of VPS10-containing receptors, including sorLA/LR11. sorLA/LR11 binds the amyloid precursor protein (APP). The exact transport itinerary of the neuronal retromer sorting pathway remains undetermined (?). ER indicates endoplasmic reticulum, NUC, nucleus; and SNX, sorting nexin.

Publication

Retromer Sorting. () Scott A. Small. Arch Neurol. ;65(3):323-328. Figure: F1. All organisms Homo sapiens Drosophila melanogaster Saccharomyces cerevisiae S288C

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