Schematic illustration of overview of one-carbon metabolism pathway, linking to methylation reactions and nucleotide synthesis

Schematic illustration of overview of one-carbon metabolism pathway, linking to methylation reactions and nucleotide synthesis. Hcy, homocysteine; SAM, S-adenosylmethionine; SAH, adenosylhomocysteine; THF, tetrahydrofolate; DHF, dihydrofolate; dUMP, deoxyuridine monophosphate and dUTP, deoxythymidine monophosphate.
Schematic illustration of overview of one-carbon metabolism pathway, linking to methylation reactions and nucleotide synthesis
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Publication

One-carbon metabolism and breast cancer: an epidemiological perspective. () Xinran Xu, et al. J Genet Genomics. ;36(4):203-214. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates SAH SAH ncbigene_synonym ACSM3 6296
Homo sapiens Primates MTRR MTRR ncbigene_symbol MTRR 4552
Homo sapiens Primates MTR MTR ncbigene_symbol MTR 4548
Homo sapiens Primates BHMT BHMT ncbigene_symbol BHMT 635
Homo sapiens Primates CSHMT CSHMT ncbigene_synonym SHMT1 6470
Homo sapiens Primates RFC1 RFC1 ncbigene_symbol RFC1 5981
Homo sapiens Primates RFC1 RFC1 ncbigene_synonym SLC19A1 6573
Homo sapiens Primates MTHFR MTHFR ncbigene_symbol MTHFR 4524
Homo sapiens Primates TAS TAS ncbigene_synonym THAS 7055
Homo sapiens Primates MTX MTX ncbigene_synonym MTX1 4580
Danio rerio Vertebrates MTRR MTRR ncbigene_symbol mtrr 560667
Danio rerio Vertebrates MTR MTR ncbigene_symbol mtr 378847
Danio rerio Vertebrates BHMT BHMT ncbigene_symbol bhmt 322228
Danio rerio Vertebrates RFC1 RFC1 ncbigene_symbol rfc1 100037336
Danio rerio Vertebrates MTHFR MTHFR ncbigene_symbol mthfr 567547

Chemical mentions

Word Match MeSH Name ChEBI
5-FU Fluorouracil mesh:D005472 5-fluorouracil chebi:46345
glycine Glycine mesh:D005998 glycine chebi:15428
Methionine NA mesh:D008715
serine Serine mesh:D012694 L-serine chebi:17115

Disease mentions

Word Match MeSH Name DOID