Network analysis using Ingenuity pathway analysis (IPA) software

Network analysis using Ingenuity pathway analysis (IPA) software. This figure depicts the merged networks of proteins/molecules targeted for novel therapies in HNSCCs. These proteins/molecules form a complex network responsible for survival and proliferation of cancer cells. Therefore, targeting this complex network with single agents or monotherapy is often a failure as blocking a single pathway triggers alternate signaling cascades to activate downstream targets for survival. The bold lines show a direct association among different proteins/molecules while the dashed lines represent indirect regulation or association among these proteins. As shown, all members of Erb family are directly associated; hence dowregulating/blocking one of the members does not block downstream signaling via Ras/Raf/Mapk and PI3K/Akt/mTOR pathway completely. Also, as shown in figure, these pathways are also being regulated by Insulin, TGF-β and KDR (VEGFR), PDGFR and HIF1α.

Publication

Overview of current and future biologically based targeted therapies in head and neck squamous cell carcinoma. (2009) Ajay Matta, et al. Head Neck Oncol. 2009;1:6-6. Figure: F2. All organisms Homo sapiens Danio rerio

Disease mentions