TGFBeta-related signalling pathway controlling Myc activity in keratinocytes
TGFβ-related signalling pathway controlling Myc activity in keratinocytes. The IKKα–Smad2/3 axis induces Mad1 and Ovol 1 expression on TGFβ stimulation. These proteins may inhibit the activity and expression of Myc, inducing in turn keratinocyte cycle exit and differentiation. Interestingly, a TGFβ–Smad3/4 signalling pathway, which is not associated with IKKα, but functions in cooperation with E2F4/5 transcription factors, has also been shown to negatively control c-Myc expression in keratinocytes ().
Publication
IKKα, a critical regulator of epidermal differentiation and a suppressor of skin cancer. (2008) Pascal Descargues, et al. EMBO J. 2008 Oct 22;27(20):2639-2647. Figure: F4.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | Myc | MYC | ncbigene_symbol | MYC | 4609 |
| Homo sapiens | Primates | E2F4 | E2F4 | ncbigene_symbol | E2F4 | 1874 |
| Homo sapiens | Primates | Mad1,Ovol1 | MAD1 | ncbigene_synonym | MXD1 | 4084 |
| Homo sapiens | Primates | Mad1,Ovol1 | MAD1 | ncbigene_synonym | MAD1L1 | 8379 |
| Homo sapiens | Primates | Mad1,Ovol1 | OVOL1 | ncbigene_symbol | OVOL1 | 5017 |
| Word | Match | MeSH | Name | ChEBI |
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Disease mentions
| Word | Match | MeSH | Name | DOID |
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