EGF signaling pathway generated by the Ingenuity Pathway Analysis (IPA) software
EGF signaling pathway generated by the Ingenuity Pathway Analysis (IPA) software. EGF and PDGF signaling pathways were the top two pathways in the top 10 functions/diseases associated with the high fertility spermatozoa (Table 2). Each node represents a protein; proteins in shaded nodes were found in the high fertility spermatozoa dataset (see additional file ) while proteins in clear nodes were not found in the high fertility spermatozoa dataset.
Publication
Comprehensive proteomic analysis of bovine spermatozoa of varying fertility rates and identification of biomarkers associated with fertility. (2008) Divyaswetha Peddinti, et al. BMC Syst Biol. 2008;2:19-19. Figure: F3.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Drosophila melanogaster | Invertebrates | EGF | EGF | ncbigene_synonym | Egfr | 37455 |
| Drosophila melanogaster | Invertebrates | RásGAP | RASGAP | ncbigene_synonym | vap | 32569 |
| Drosophila melanogaster | Invertebrates | RásGAP | RASGAP | ncbigene_synonym | RasGAP1 | 39158 |
| Drosophila melanogaster | Invertebrates | GAP | GAP | ncbigene_synonym | Gapdh2 | 32545 |
| Drosophila melanogaster | Invertebrates | GAP | GAP | ncbigene_synonym | CdGAPr | 35267 |
| Drosophila melanogaster | Invertebrates | GAP | GAP | ncbigene_synonym | Gapdh1 | 35728 |
| Drosophila melanogaster | Invertebrates | GAP | GAP | ncbigene_synonym | ArfGAP1 | 39417 |
| Drosophila melanogaster | Invertebrates | Rás | RAS | ncbigene_symbol | ras | 43873 |
| Drosophila melanogaster | Invertebrates | Rás | RAS | ncbigene_synonym | Ras64B | 38494 |
| Drosophila melanogaster | Invertebrates | Rás | RAS | ncbigene_synonym | Ras85D | 41140 |
| Drosophila melanogaster | Invertebrates | sos | SOS | ncbigene_symbol | Sos | 34790 |
| Drosophila melanogaster | Invertebrates | PLCG1 | PLCG1 | ncbigene_synonym | sl | 32601 |
| Drosophila melanogaster | Invertebrates | GRB2 | GRB2 | ncbigene_synonym | drk | 36497 |
| Drosophila melanogaster | Invertebrates | SHC | SHC | ncbigene_symbol | Shc | 44052 |
| Drosophila melanogaster | Invertebrates | P13K | PI3K | ncbigene_synonym | Pi3K21B | 33203 |
| Drosophila melanogaster | Invertebrates | P13K | PI3K | ncbigene_synonym | Pi3K59F | 37733 |
| Drosophila melanogaster | Invertebrates | P13K | PI3K | ncbigene_synonym | Pi3K68D | 39329 |
| Drosophila melanogaster | Invertebrates | P13K | PI3K | ncbigene_synonym | Pi3K92E | 42446 |
| Drosophila melanogaster | Invertebrates | MEKK1 | MEKK1 | ncbigene_symbol | Mekk1 | 42253 |
| Drosophila melanogaster | Invertebrates | MKK7 | MKK7 | ncbigene_synonym | hep | 32256 |
| Drosophila melanogaster | Invertebrates | MKK4 | MKK4 | ncbigene_symbol | Mkk4 | 41020 |
| Drosophila melanogaster | Invertebrates | ERK2 | ERK2 | ncbigene_synonym | p38a | 42866 |
| Drosophila melanogaster | Invertebrates | CK2 | CK2 | ncbigene_synonym | CkIIbeta | 32132 |
| Drosophila melanogaster | Invertebrates | CK2 | CK2 | ncbigene_synonym | CkIIbeta2 | 37300 |
| Drosophila melanogaster | Invertebrates | CK2 | CK2 | ncbigene_synonym | CkIIalpha | 48448 |
| Drosophila melanogaster | Invertebrates | SRF | SRF | ncbigene_symbol | Srf | 252723 |
| Drosophila melanogaster | Invertebrates | SRF | SRF | ncbigene_synonym | mal | 33045 |
| Drosophila melanogaster | Invertebrates | SRF | SRF | ncbigene_synonym | bs | 37890 |
| Drosophila melanogaster | Invertebrates | and | AND | ncbigene_synonym | Andorra | 32798 |
| Drosophila melanogaster | Invertebrates | and | AND | ncbigene_synonym | Anp | 43595 |
| Drosophila melanogaster | Invertebrates | and | AND | ncbigene_synonym | Acam | 44913 |
| Homo sapiens | Primates | EGF | EGF | ncbigene_symbol | EGF | 1950 |
| Homo sapiens | Primates | RásGAP | RASGAP | ncbigene_synonym | RASA1 | 5921 |
| Homo sapiens | Primates | GAP | GAP | ncbigene_synonym | RGS6 | 9628 |
| Homo sapiens | Primates | Rás | RAS | famplex_relations | KRAS | 3845 |
| Homo sapiens | Primates | Rás | RAS | famplex_relations | HRAS | 3265 |
| Homo sapiens | Primates | Rás | RAS | famplex_relations | NRAS | 4893 |
| Homo sapiens | Primates | sos | SOS | ncbigene_synonym | XYLT2 | 64132 |
| Homo sapiens | Primates | sos | SOS | famplex_relations | SOS1 | 6654 |
| Homo sapiens | Primates | sos | SOS | famplex_relations | SOS2 | 6655 |
| Homo sapiens | Primates | PLCG1 | PLCG1 | ncbigene_symbol | PLCG1 | 5335 |
| Homo sapiens | Primates | GRB2 | GRB2 | ncbigene_symbol | GRB2 | 2885 |
| Homo sapiens | Primates | SHC | SHC | ncbigene_synonym | SHC1 | 6464 |
| Homo sapiens | Primates | SHC | SHC | famplex_relations | SHC2 | 25759 |
| Homo sapiens | Primates | SHC | SHC | famplex_relations | SHC3 | 53358 |
| Homo sapiens | Primates | SHC | SHC | famplex_relations | SHC4 | 399694 |
| Homo sapiens | Primates | P13K | PI3K | ncbigene_synonym | PIK3CA | 5290 |
| Homo sapiens | Primates | P13K | PI3K | ncbigene_synonym | PIK3CB | 5291 |
| Homo sapiens | Primates | P13K | PI3K | ncbigene_synonym | PIK3CD | 5293 |
| Homo sapiens | Primates | P13K | PI3K | ncbigene_synonym | PIK3CG | 5294 |
| Homo sapiens | Primates | P13K | PI3K | famplex_relations | PIK3R3 | 8503 |
| Homo sapiens | Primates | P13K | PI3K | famplex_relations | PIK3R4 | 30849 |
| Homo sapiens | Primates | P13K | PI3K | famplex_relations | PIK3R5 | 23533 |
| Homo sapiens | Primates | P13K | PI3K | famplex_relations | PIK3R6 | 146850 |
| Homo sapiens | Primates | P13K | PI3K | famplex_relations | PIK3R1 | 5295 |
| Homo sapiens | Primates | P13K | PI3K | famplex_relations | PIK3R2 | 5296 |
| Homo sapiens | Primates | MEKK1 | MEKK1 | ncbigene_synonym | MAP3K1 | 4214 |
| Homo sapiens | Primates | STAT3 | STAT3 | ncbigene_symbol | STAT3 | 6774 |
| Homo sapiens | Primates | MEK1 | MEK1 | ncbigene_synonym | MAP2K1 | 5604 |
| Homo sapiens | Primates | MKK7 | MKK7 | ncbigene_synonym | MAP2K7 | 5609 |
| Homo sapiens | Primates | MKK4 | MKK4 | ncbigene_synonym | MAP2K4 | 6416 |
| Homo sapiens | Primates | ERK2 | ERK2 | ncbigene_synonym | MAPK1 | 5594 |
| Homo sapiens | Primates | JNK1 | JNK1 | ncbigene_synonym | MAPK8 | 5599 |
| Homo sapiens | Primates | CK2 | CK2 | famplex_relations | CSNK2A1 | 1457 |
| Homo sapiens | Primates | CK2 | CK2 | famplex_relations | CSNK2A2 | 1459 |
| Homo sapiens | Primates | CK2 | CK2 | famplex_relations | CSNK2B | 1460 |
| Homo sapiens | Primates | SRF | SRF | ncbigene_symbol | SRF | 6722 |
| Homo sapiens | Primates | (Elk-1 | ELK1 | ncbigene_symbol | ELK1 | 2002 |
| Homo sapiens | Primates | (Elk-1 | ELK1 | ncbigene_synonym | KCNH4 | 23415 |
| Homo sapiens | Primates | (Elk-1 | ELK1 | ncbigene_synonym | KCNH8 | 131096 |
| Word | Match | MeSH | Name | ChEBI |
|---|
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|---|---|---|---|
| Noonan syndrome | NA |