Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chk1

Fig. 6. Model for potential checkpoint function of HuCdc6. Ongoing DNA replication is monitored either by proteins at the replication fork, including ATR, or by soluble factors, including HuCdc6. ATR and HuCdc6 might work in parallel pathways, both leading to the activation of Chk1 and consequent inactivation of Cdc25. The major role of the ATR pathway would be in response to stalled replication forks. Chk1 may also increase the activity of Wee1 that further prevents the activation of MPF.
Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chk1
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Publication

Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chk1. (2003) Lorena Clay-Farrace, et al. EMBO J. 2003 Feb 3;22(3):704-712. Figure: F6.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Arabidopsis thaliana Plants and Fungi Cdt1 CDT1 ncbigene_symbol CDT1 2745823
Arabidopsis thaliana Plants and Fungi Cdt1 CDT1 ncbigene_synonym CDT1A 817684
Arabidopsis thaliana Plants and Fungi Cdt1 CDT1 ncbigene_synonym CDT1B 824636
Arabidopsis thaliana Plants and Fungi G1 G1 ncbigene_symbol G1 824342
Arabidopsis thaliana Plants and Fungi pol POL ncbigene_symbol POL 819306
Arabidopsis thaliana Plants and Fungi ATR ATR ncbigene_symbol ATR 834082
Arabidopsis thaliana Plants and Fungi RPA RPA ncbigene_symbol RPA 818088
Arabidopsis thaliana Plants and Fungi Cdc25 CDC25 ncbigene_symbol CDC25 831832
Arabidopsis thaliana Plants and Fungi Weel WEE1 ncbigene_symbol WEE1 839453

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID