The mechanisms for DAP/Lys synthesis

The mechanisms for DAP/Lys synthesis. The pathways labeled in the diagram include two variants that use either succinylCoA or acetylCoA. Another uses Ddh to directly convert THDPA to m-DAP. The enzyme reported in this article, ll-DAP-AT, directly converts THDPA to ll-DAP. The DAP dehydrogenase and ll-DAP-AT diagrams show only the enzymatic step that differentiates these pathways from the acyl-DAP pathways. Acronyms in the diagram include THDPA, l-2,3,4,5-tetrahydrodipicolinate; ll-DAP, ll-2,5-diaminopimelate; m-DAP, m-2,6-diaminopimelate; DapA, dihydrodipicolninate synthase; DapB, dihydrodipicolinate reductase; DapD, THDPA acyltransferase; DapC, N-acyl-l-2-amino-6-oxopimelate aminotransferase; DapE, N-acyl-ll-2,6-diaminopimelate deacylase; DapF, DAP epimerase; and LysA, m-DAP decarboxylase. The structures of the intermediates are shown on the left.

Publication

An ll-Diaminopimelate Aminotransferase Defines a Novel Variant of the Lysine Biosynthesis Pathway in Plants. (2006) André O. Hudson, et al. Plant Physiol. 2006 Jan;140(1):292-301. Figure: F1. Escherichia coli str. K-12 substr. MG1655

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