Sterol/steroid biosynthesis in plant and in human

Sterol/steroid biosynthesis in plant and in human. A, DWF1 function in the biosynthetic pathway for plant sterols and steroids (brassinolide). The enzyme catalyzes both the isomerization of the Δ24(28) bond into a Δ24(25) bond and the subsequent reduction of the Δ24(25) bond from plant-sterol intermediates 24-methylenecholesterol and isofucosterol, to produce campesterol (plant-steroid precursor) and sitosterol (major plant sterol), respectively. B, Reduction, by DWF1, of the Δ24(25) bond from plant-sterol intermediates, which resembles the reduction, catalyzed by DHCR24 and required for the synthesis of cholesterol, of the Δ24 bond from desmosterol.

Publication

Mutations in the 3β-Hydroxysterol Δ24-Reductase Gene Cause Desmosterolosis, an Autosomal Recessive Disorder of Cholesterol Biosynthesis. (2001) Hans R. Waterham, et al. Am J Hum Genet. 2001 Oct;69(4):685-694. Figure: F2.

Disease mentions