The central carbon metabolism of E

A schematic representation of the central carbon metabolism of E. coli (adapted from ref. ). Experimental fluxes are labeled v1–v24 and are measured in the direction of the arrows. Note that in some cases, flux flows in the opposite direction and is measured by a negative value. The thick arrows highlight the short alternative pathway (v19–v18–v21) predicted by ROOM in response to the knockout of pyk (marked with an X) under medium-glucose growth conditions. Major changes in flux along this pathway were experimentally determined (). See the supporting information for the mapping between the experimental fluxes and model reactions. (Note that unlabeled reactions such as 6PG to KDPG were not experimentally measured.)
The central carbon metabolism of E
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Publication

Regulatory on/off minimization of metabolic flux changes after genetic perturbations. (2005) Tomer Shlomi, et al. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7695-7700. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Drosophila melanogaster Invertebrates G6P G6P ncbigene_symbol G6P 33476
Drosophila melanogaster Invertebrates gnd GND ncbigene_symbol gnd 5656923
Drosophila melanogaster Invertebrates pgi PGI ncbigene_symbol Pgi 35886
Drosophila melanogaster Invertebrates pyk PYK ncbigene_symbol PyK 42620
Drosophila melanogaster Invertebrates LAC LAC ncbigene_symbol Lac 36363
Drosophila melanogaster Invertebrates LAC LAC ncbigene_synonym lacquered 44521
Drosophila melanogaster Invertebrates PEP PEP ncbigene_symbol Pep 45961
Drosophila melanogaster Invertebrates PEP PEP ncbigene_synonym bgcn 47873
Drosophila melanogaster Invertebrates PYR PYR ncbigene_symbol pyr 36255
Drosophila melanogaster Invertebrates ACE ACE ncbigene_symbol Ace 41625
Drosophila melanogaster Invertebrates ACE ACE ncbigene_synonym Acer 34189
Drosophila melanogaster Invertebrates ACE ACE ncbigene_synonym Ance 34805
Drosophila melanogaster Invertebrates ACA ACA ncbigene_synonym tRNA:Thr-TGT-1-1 3771902
Drosophila melanogaster Invertebrates ACA ACA ncbigene_synonym tRNA:Thr-TGT-2-1 3771937
Drosophila melanogaster Invertebrates ACA ACA ncbigene_synonym tRNA:Thr-TGT-2-2 3772144
Drosophila melanogaster Invertebrates ACA ACA ncbigene_synonym tRNA:Thr-TGT-2-5 3772291
Drosophila melanogaster Invertebrates ACA ACA ncbigene_synonym tRNA:Thr-TGT-2-4 19835230
Drosophila melanogaster Invertebrates ACA ACA ncbigene_synonym tRNA:Thr-TGT-2-3 19836221
Drosophila melanogaster Invertebrates MAL MAL ncbigene_symbol mal 33045
Drosophila melanogaster Invertebrates MAL MAL ncbigene_synonym bs 37890
Drosophila melanogaster Invertebrates MAL MAL ncbigene_synonym Mrtf 38338
Drosophila melanogaster Invertebrates CIT CIT ncbigene_synonym sti 39429
Drosophila melanogaster Invertebrates FUM FUM ncbigene_synonym Fum1 31605
Drosophila melanogaster Invertebrates CYCLE CYCLE ncbigene_synonym CycE 34924
Drosophila melanogaster Invertebrates CYCLE CYCLE ncbigene_synonym cyc 40162
Drosophila melanogaster Invertebrates V16 V16 ncbigene_synonym Vps16A 41107
Drosophila melanogaster Invertebrates ARG ARG ncbigene_symbol arg 46717
Drosophila melanogaster Invertebrates ARG ARG ncbigene_synonym aos 39833
Drosophila melanogaster Invertebrates OGA OGA ncbigene_symbol Oga 42518
Drosophila melanogaster Invertebrates SUC SUC ncbigene_symbol Suc 5656984
Drosophila melanogaster Invertebrates COA COA ncbigene_symbol Coa 248135
Escherichia coli str. K-12 substr. MG1655 Bacteria zwf ZWF ncbigene_symbol zwf 946370
Escherichia coli str. K-12 substr. MG1655 Bacteria gnd GND ncbigene_symbol gnd 946554
Escherichia coli str. K-12 substr. MG1655 Bacteria pgi PGI ncbigene_symbol pgi 948535
Escherichia coli str. K-12 substr. MG1655 Bacteria ppc PPC ncbigene_symbol ppc 948457
Escherichia coli str. K-12 substr. MG1655 Bacteria ARG ARG ncbigene_synonym carA 949025
Homo sapiens Primates V1 V1 ncbigene_synonym MTPN 136319
Homo sapiens Primates pgi PGI ncbigene_synonym BGN 633
Homo sapiens Primates pgi PGI ncbigene_synonym GPI 2821
Homo sapiens Primates pgi PGI ncbigene_synonym PGPEP1 54858
Homo sapiens Primates v12 V12 ncbigene_synonym IGLV2-8 28817
Homo sapiens Primates C1 C1 famplex_relations C1QA 712
Homo sapiens Primates C1 C1 famplex_relations C1QB 713
Homo sapiens Primates C1 C1 famplex_relations C1QC 714
Homo sapiens Primates C1 C1 famplex_relations C1R 715
Homo sapiens Primates C1 C1 famplex_relations C1S 716
Homo sapiens Primates pyk PYK ncbigene_synonym PHKA2 5256
Homo sapiens Primates LAC LAC ncbigene_synonym LCT 3938
Homo sapiens Primates PEP PEP ncbigene_synonym PAEP 5047
Homo sapiens Primates PEP PEP ncbigene_synonym PREP 5550
Homo sapiens Primates PEP PEP ncbigene_synonym PTPN22 26191
Homo sapiens Primates ACE ACE ncbigene_symbol ACE 1636
Homo sapiens Primates V19 V19 ncbigene_synonym SRI 6717
Homo sapiens Primates V19 V19 ncbigene_synonym IGLV2-33 28811
Homo sapiens Primates V21 V21 ncbigene_synonym IGLV3-1 28809
Homo sapiens Primates V13 V13 ncbigene_synonym IGLV2-11 28816
Homo sapiens Primates MAL MAL ncbigene_symbol MAL 4118
Homo sapiens Primates MAL MAL ncbigene_synonym MRTFA 57591
Homo sapiens Primates MAL MAL ncbigene_synonym TIRAP 114609
Homo sapiens Primates CIT CIT ncbigene_symbol CIT 11113
Homo sapiens Primates CIT CIT ncbigene_synonym DHDDS 79947
Homo sapiens Primates V17 V17 ncbigene_synonym IGLV2-23 28813
Homo sapiens Primates V14 V14 ncbigene_synonym IGLV2-14 28815
Homo sapiens Primates ARG ARG ncbigene_synonym ABL2 27
Homo sapiens Primates ARG ARG ncbigene_synonym RERE 473
Homo sapiens Primates OGA OGA ncbigene_symbol OGA 10724
Homo sapiens Primates V15 V15 ncbigene_synonym IGLV2-18 28814

Chemical mentions

Word Match MeSH Name ChEBI
ALA VAL LEU Alanine mesh:D000409 alanine chebi:16449
ARG Arginine mesh:D001120 arginine chebi:29016
GLY Glycine mesh:D005998 glycine chebi:15428
ALA VAL LEU Leucine mesh:D007930 L-leucine chebi:15603
PRO Proline mesh:D011392 L-proline chebi:17203
ALA VAL LEU Valine mesh:D014633 L-valine chebi:16414

Disease mentions

Word Match MeSH Name DOID