Illustration representing the sites of action of different polyphenols in cancer pathway
Illustration representing the sites of action of different polyphenols in cancer pathway. Activation of oncogene triggers abnormal cell division and finally results in tumor cells followed by metastasis. DNA crosslinking, DNA damage, abnormal p53 activities, and microtubule disruption collectively result in abnormal apoptosis and cell cycle arrest which cause cancer. Different polyphenols probably work on these pathways to prevent cancer. The figure was designed by Biorender.com program (https://biorender.com/, accessed on 20 March 2024)
Publication
Polyphenols as Therapeutics in Respiratory Diseases: Moving from Preclinical Evidence to Potential Clinical Applications (2024) Talha Bin Emran, et al. Int J Biol Sci. 2024;20(8). Figure: F4.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | MMP-2,MMP-9and | MMP-2 | ncbigene_synonym | MMP2 | 4313 |
| Homo sapiens | Primates | MMP-9 | MMP-9 | ncbigene_synonym | MMP9 | 4318 |
| Homo sapiens | Primates | plasminogen | PLG | ncbigene_symbol | PLG | 5340 |
| Homo sapiens | Primates | (uPA) | UPA | ncbigene_synonym | PLAU | 5328 |
| Homo sapiens | Primates | (uPA) | UPA | ncbigene_synonym | PRAP1 | 118471 |
| Homo sapiens | Primates | PAI-1,TIMP-1,andTIMP-2 | TIMP-1 | ncbigene_synonym | TIMP1 | 7076 |
| Homo sapiens | Primates | PAI-1,TIMP-1,andTIMP-2 | PAI-1 | ncbigene_synonym | SERPINE1 | 5054 |
| Homo sapiens | Primates | TIMP-2 | TIMP2 | ncbigene_symbol | TIMP2 | 7077 |
| Homo sapiens | Primates | C1 | C1 | famplex_relations | C1QA | 712 |
| Homo sapiens | Primates | C1 | C1 | famplex_relations | C1QB | 713 |
| Homo sapiens | Primates | C1 | C1 | famplex_relations | C1QC | 714 |
| Homo sapiens | Primates | C1 | C1 | famplex_relations | C1R | 715 |
| Homo sapiens | Primates | C1 | C1 | famplex_relations | C1S | 716 |
| Homo sapiens | Primates | G2 | G2 | ncbigene_synonym | WARS1 | 7453 |
| Homo sapiens | Primates | P53 | P53 | ncbigene_synonym | TP53 | 7157 |
| Homo sapiens | Primates | P53 | P53 | famplex_relations | TP63 | 8626 |
| Homo sapiens | Primates | P53 | P53 | famplex_relations | TP73 | 7161 |
| Homo sapiens | Primates | Rad51&phospho-AKT | RAD51 | ncbigene_symbol | RAD51 | 5888 |
| Homo sapiens | Primates | -Caspase | CASPASE | famplex_relations | CASP1 | 834 |
| Homo sapiens | Primates | -Caspase | CASPASE | famplex_relations | CASP2 | 835 |
| Homo sapiens | Primates | -Caspase | CASPASE | famplex_relations | CASP4 | 837 |
| Homo sapiens | Primates | -Caspase | CASPASE | famplex_relations | CASP5 | 838 |
| Homo sapiens | Primates | -Caspase | CASPASE | famplex_relations | CASP6 | 839 |
| Homo sapiens | Primates | -Caspase | CASPASE | famplex_relations | CASP8 | 841 |
| Homo sapiens | Primates | -Caspase | CASPASE | famplex_relations | CASP9 | 842 |
| Homo sapiens | Primates | -Caspase | CASPASE | famplex_relations | CASP10 | 843 |
| Homo sapiens | Primates | -Caspase | CASPASE | famplex_relations | CASP12 | 100506742 |
| Homo sapiens | Primates | -Caspase | CASPASE | famplex_relations | CASP14 | 23581 |
| Homo sapiens | Primates | -Caspase | CASPASE | famplex_relations | CASP3 | 836 |
| Homo sapiens | Primates | -Caspase | CASPASE | famplex_relations | CASP7 | 840 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| Peonidin-3-glucoside | Peonidin-3-glucoside | 5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)chromenium-3-yl beta-D-glucopyranoside | chebi:74793 | |
| DNA | DNA | deoxyribonucleic acids | chebi:16991 | |
| Baicalein | baicalein | 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-olate | chebi:78324 | |
| Xanthohumol | xanthohumol | xanthohumol | chebi:66331 | |
| Anthocyanidins | anthocyanidins | chebi:38695 | ||
| Resveratrol | Resveratrol | trans-resveratrol | chebi:45713 | |
| procyanidin C1 | Procyanidin C1 | (2R,2'R,2''R,3R,3'R,3''R,4R,4'S)-2,2',2''-tris(3,4-dihydroxyphenyl)-3,3',3'',4,4',4''-hexahydro-2H,2'H,2''H-4,8':4',8''-terchromene-3,3',3'',5,5',5'',7,7',7''-nonol | chebi:75643 | |
| Apigenin | apigenin | 5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-olate | chebi:58470 | |
| Apigenin | apigenin | 5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-olate | chebi:58470 | |
| EGCG | EGCG | (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate | chebi:4806 | |
| Naringenin | NARINGENIN | (2S)-naringenin | chebi:17846 | |
| Resveratrol | Resveratrol | trans-resveratrol | chebi:45713 | |
| Baicalein | baicalein | 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-olate | chebi:78324 | |
| Genistein | Genistein | 5-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl beta-D-glucopyranoside | chebi:27514 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|