Inappropriate STAT activation in cancer cells

Mechanisms of inappropriate STAT activation in cancer cells. STATs can be activated constitutively in cancer cells through a variety of mechanisms. This can include autocrine or paracrine production of cytokines that can activate these pathways, activation of upstream kinases through mutation (such as in JAKs), overexpression (such as EGFR), inappropriate activation (such as SRC), or activating translocations (such as in BCR-ABL), and loss of negative regulators (such as SOCS3). Rarely, the STATs can be activated by mutation within the STAT itself
Inappropriate STAT activation in cancer cells
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Publication

Oncogenic STAT Transcription Factors as Targets for Cancer Therapy: Innovative Strategies and Clinical Translation (2024) Weiyuan Wang, et al. Cancers (Basel). 2024 Apr;16(7). Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates EGFR EGFR ncbigene_symbol EGFR 1956
Homo sapiens Primates JAK JAK famplex_relations JAK1 3716
Homo sapiens Primates JAK JAK famplex_relations JAK2 3717
Homo sapiens Primates JAK JAK famplex_relations JAK3 3718
Homo sapiens Primates JAK JAK famplex_relations TYK2 7297
Homo sapiens Primates SRC SRC ncbigene_symbol SRC 6714
Homo sapiens Primates SRC SRC famplex_relations FGR 2268
Homo sapiens Primates SRC SRC famplex_relations FYN 2534
Homo sapiens Primates SRC SRC famplex_relations YES1 7525
Homo sapiens Primates STAT STAT ncbigene_synonym SOAT1 6646
Homo sapiens Primates STAT STAT famplex_relations STAT1 6772
Homo sapiens Primates STAT STAT famplex_relations STAT2 6773
Homo sapiens Primates STAT STAT famplex_relations STAT3 6774
Homo sapiens Primates STAT STAT famplex_relations STAT4 6775
Homo sapiens Primates STAT STAT famplex_relations STAT6 6778
Homo sapiens Primates STAT STAT famplex_relations STAT5A 6776
Homo sapiens Primates STAT STAT famplex_relations STAT5B 6777
Homo sapiens Primates BCR BCR ncbigene_symbol BCR 613
Homo sapiens Primates BCR BCR ncbigene_synonym RN7SL263P 106480993
Homo sapiens Primates ABL ABL ncbigene_synonym ABL1 25
Homo sapiens Primates ABL ABL ncbigene_synonym MTTP 4547
Homo sapiens Primates ABL ABL ncbigene_synonym DSP-AS1 101928076
Homo sapiens Primates ABL ABL famplex_relations ABL2 27
Homo sapiens Primates socs SOCS ncbigene_synonym CISH 1154

Chemical mentions

Word Match MeSH Name ChEBI
Nucleus nucleus nucleus chebi:33252
ABL ABL dodecanoic acid chebi:30805

Disease mentions

Word Match MeSH Name DOID