Exploring the regulatory mechanism of intestinal flora based on PD-1 receptor/ligand targeted cancer immunotherapy

Intestinal flora increases the anti-PD-1 therapeutic effect by regulating immune cells. Akkermansia muciniphila accelerated the activity of CXCR3+CCR9+CD4+T cells, produced more IFN-γ. Bacteroidales inhibited the infiltration of B cells and T cells. Bifidobacterium and Olsenella produced metabolites inosine and increase the levels of interleukin-12 (IL-12), interferon γ (IFN-γ), TNF-a and interleukin-2 (IL-2). Bifidobacterium bifidum promotes the activation of T cells and B cells. Enterococcus faecium releases the metabolite SagA, produces NOD2 active polypeptide, and promotes the activation of B cells, T cells. Enterococcus hirae promotes tumor cell apoptosis, weakens the proliferation and migration of tumor cells, promotes the infiltration of T cells, B cells, promotes the activation of CD8+ T cells. Faecalibacterium promotes the activation of CD8+ T cells. Lactobacillus rhamnosus GG (LGG), induces IFN-β production, promotes CD8+ T cell activation via the cGAS/STING pathway in DC. Lactobacillus johnsonii enhances the immunotherapy effect through the metabolite hypoxanthine. Ruminococcaceae increases the number of effector T cells, induces the activation of effector CD4+ and CD8+ T cells, increases tumor CD8+ T cell infiltration.

Publication

Exploring the regulatory mechanism of intestinal flora based on PD-1 receptor/ligand targeted cancer immunotherapy. (2024) Xinran Gao, et al. Front Immunol. 2024;15:1359029. Figure: F2. Homo sapiens

Disease mentions